Zobrazeno 1 - 10
of 142
pro vyhledávání: '"DMSO - Dimethylsulfoxide"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 36-48 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Highlights • Euc decreased expression of p-STAT3 (Tyr705), nuclear translocation and DNA-binding. • Euc inhibited cell viability, metastasis and BCSC-like traits by inhibiting STAT3. • Euc covalently interacted with STAT3 through a Michael addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a026eeb0640a7c0074c108e405eb6e54
http://www.sciencedirect.com/science/article/pii/S1476558620301676
http://www.sciencedirect.com/science/article/pii/S1476558620301676
Autor:
Lupei Du, Xiaodong Shi, Yuxing Lin, Xiaojun Qin, Minyong Li, Hui Song, Xiang Li, Zheng Zhang, Gaopan Dong, Zhongxia Yu, Wei Zhao, Zhenzhen Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1669-1679 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitin-proteasome system (UPS), thereby selectively reducing the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2ee89c25ae13d3b9aa09ea20848e78
http://www.sciencedirect.com/science/article/pii/S2211383519313188
http://www.sciencedirect.com/science/article/pii/S2211383519313188
Publikováno v:
The Journal of Biological Chemistry
DNA-protein cross-links are formed when proteins become covalently trapped with DNA in the presence of exogenous or endogenous alkylating agents. If left unrepaired, they inhibit transcription as well as DNA unwinding during replication and may resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12da75175a6f1d5dc67c70d562210114
https://pubmed.ncbi.nlm.nih.gov/34461101
https://pubmed.ncbi.nlm.nih.gov/34461101
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Autor:
Jing Yang, Ramesh Neelamegam, Jinchun Song, Gengyang Yuan, Ping Bai, Chongzhao Ran, Marc D. Normandin, Changning Wang, Michael S. Placzek, Zude Chen, Hayden R. Schmidt, Stephanie A. Fiedler, Hao Wang, Yu Lan, Xiying Qu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1204-1215 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a5701aa32f8f8afaa0cf073ac28afc
https://doi.org/10.1016/j.apsb.2019.07.002
https://doi.org/10.1016/j.apsb.2019.07.002
Autor:
Vo, Dat T., Karanam, Narasimha Kumar, Ding, Lianghao, Saha, Debabrata, Yordy, John S., Giri, Uma, Heymach, John V., Story, Michael D.
Publikováno v:
Neoplasia (New York, N.Y.)
MicroRNAs (miRNAs) are short single-stranded RNAs, measuring 21 to 23 nucleotides in length and regulate gene expression at the post-transcriptional level through mRNA destabilization or repressing protein synthesis. Dysregulation of miRNAs can lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65e42cbfcc3be79653e0b382f66f3a0f
http://europepmc.org/articles/PMC6642270
http://europepmc.org/articles/PMC6642270
Autor:
Weiying Zhang, Xueli Fu, Bowen Liu, Lu Zhang, Lihong Ye, Xue Wang, Tianjiao Wang, Kai Ye, Feifei Xu, Tianzhi Jin, Yue Wu
Publikováno v:
EBioMedicine
Background Abnormal construction of the extracellular matrix (ECM) is intimately linked with carcinogenesis and the development of solid tumours, especially hepatocellular carcinoma (HCC). As the major component of the ECM, collagen plays a pivotal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57215d87506c1b3fb9365ffcf333d32
http://europepmc.org/articles/PMC6642319
http://europepmc.org/articles/PMC6642319
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 144-156 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 144-156 (2019)
Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741217633748b64d45c5b084c61c9e6
https://doi.org/10.1016/j.apsb.2018.08.003
https://doi.org/10.1016/j.apsb.2018.08.003
Autor:
Pratibha P, Ghodke, Gabriela, Gonzalez-Vasquez, Hui, Wang, Kevin M, Johnson, Carl A, Sedgeman, F Peter, Guengerich
Publikováno v:
The Journal of Biological Chemistry
Unrepaired DNA–protein cross-links, due to their bulky nature, can stall replication forks and result in genome instability. Large DNA–protein cross-links can be cleaved into DNA–peptide cross-links, but the extent to which these smaller fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::075c86f56799f19af402e5a61dd255df
https://pubmed.ncbi.nlm.nih.gov/33617883
https://pubmed.ncbi.nlm.nih.gov/33617883
Autor:
Takashi Tanaka, Masaki Ueno, Shingo Miyata, Shoko Shimizu, Yoshitaka Fujihara, Masahito Ikawa
Publikováno v:
EBioMedicine
EBioMedicine, Vol 30, Iss, Pp 62-73 (2018)
EBioMedicine, Vol 30, Iss, Pp 62-73 (2018)
Takashi Tanaka, Shoko Shimizu, Masaki Ueno, Yoshitaka Fujihara, Masahito Ikawa, Shingo Miyata, MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors, EBioMedicine, Volume 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0785cf1e63bd771b0601683e621d43
http://europepmc.org/articles/PMC5952351
http://europepmc.org/articles/PMC5952351