Zobrazeno 1 - 10
of 206
pro vyhledávání: '"DMEM, Dulbecco's modified Eagle medium"'
Autor:
Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Graphical abstract
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Autor:
Floris J.M. Roos, Qiuwei Pan, Petra E. de Ruiter, Jan N. M. IJzermans, Arif I. Ardisasmita, Henk P. Roest, Shaojun Shi, Monique M A Verstegen, Luc J. W. van der Laan, Marije Niemeijer, Wanlu Cao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)
Cellular and Molecular Gastroenterology and Hepatology
CMGH, 13(2), 541-564. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology
CMGH, 13(2), 541-564. Elsevier Inc.
Background & Aims Liver and bile duct diseases often are associated with extensive cell death of cholangiocytes. Necroptosis represents a common mode of programmed cell death in cholangiopathy, however, detailed mechanistic knowledge is limited owing
Autor:
Jinze Li, Maria M. Disotuar, Nai-Pin Lin, Jake A. Smith, Danny Hung-Chieh Chou, Steve L. Alam
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to r
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1341-1354 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Breast cancer brain metastases (BCBMs) are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth. Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 18, Iss, Pp 66-75 (2021)
Regenerative Therapy, Vol 18, Iss, Pp 66-75 (2021)
Introduction Myocardial recovery is one of the targets for heart failure treatment. A non-negligible number of heart failure with reduced ejection fraction (EF) patients experience myocardial recovery through treatment. Although myocardial hypoxia ha
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 35, Iss, Pp 245-257 (2022)
Journal of Advanced Research, Vol 35, Iss, Pp 245-257 (2022)
Graphical abstract
Highlights • Aberrant STAT3 activation can promote neoplastic transformation by affecting cellular proliferation, invasion, metastasis, angiogenesis, and anti-apoptosis induction. • Fangchinoline abrogated protein expressi
Highlights • Aberrant STAT3 activation can promote neoplastic transformation by affecting cellular proliferation, invasion, metastasis, angiogenesis, and anti-apoptosis induction. • Fangchinoline abrogated protein expressi
Autor:
Narihito Nagoshi, Taro Matsumoto, Rina Fujii-Tezuka, Ichiro Morioka, Hideyuki Okano, Shori Takahashi, Hideo Mugishima, Mika Ishige-Wada
Publikováno v:
Regenerative Therapy
Regenerative Therapy, Vol 16, Iss, Pp 1-11 (2021)
Regenerative Therapy, Vol 16, Iss, Pp 1-11 (2021)
Introduction The p75 neurotrophin receptor (p75NTR) is known as an efficient marker for the prospective isolation of mesenchymal stem cells (MSCs) and neural crest-derived stem cells (NCSCs). To date, there is quite limited information concerning p75
Autor:
Zhouhong Ge, Ron Smits, Lucia Campos Carrascosa, Dave Sprengers, Jaap Kwekkeboom, Jan N. M. IJzermans, Guoying Zhou, Maikel P. Peppelenbosch, Ruby Lieshout, Ling Wang, Wanlu Cao, Lisanne Noordam, Pengfei Li, Qin Yang, Junhong Su, Jiaye Liu, Luc J. W. van der Laan, Meng Li, Buyun Ma, Monique M A Verstegen, Qiuwei Pan, Ruyi Zhang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell–CAF interactions.
Autor:
Rui Wang, Dandan Zhong, Yiqing Qiu, Jingni Wu, Yongliang Zhu, Zhenya Song, Jingwen Liu, Hongping Wang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1433-1455 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Rapid gastric epithelial progenitor cell (EPC) proliferation and inflammatory response inhibition play key roles in promoting the repair of gastric mucosal damage. However, specific targets inducing these effects are unknown. In thi
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1002-1007 (2021)
Toxicology Reports
Toxicology Reports
Highlights • Benzyl salicylate (BS) is on priority lists for evaluation of estrogenic effects. • New data in both MCF7 (E-screen) and luciferase transactivation assays. • Potency of BS is 21′000′000-fold lower than estradiol in transactivat