Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity

Autor: Dj, Morgan, Ht, Kreuwel, Fleck S, Hi, Levitsky, Dm, Pardoll, Linda Sherman

Publikováno v: Europe PubMed Central

To determine how self-tolerance can alter the ability of the immune system to respond against tumor-associated Ags that are also expressed by normal tissue, we designed experiments in which the same protein was expressed both as a tumor Ag and as a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f11fa4d1231e25b06d00a53e32ce5970
https://pubmed.ncbi.nlm.nih.gov/9551898

Thymus-dependent and thymus-independent developmental pathways for peripheral T cell receptor-gamma delta-bearing lymphocytes

Autor: Dm, Pardoll, Bj, Fowlkes, Andrew Lew, Wl, Maloy, Ma, Weston, Ja, Bluestone, Rh, Schwartz, Je, Coligan, Am, Kruisbeek

Publikováno v: Europe PubMed Central

To elucidate the developmental pathways of T cells that bear TCR gamma delta, we have analyzed the kinetics of expression and biochemical characteristics of gamma delta receptors in the thymus and spleen of normal and athymic (nude) mice, as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::300d1fc4e0c8d77525e3f16ea1ca2989
https://pubmed.ncbi.nlm.nih.gov/3259605

Analysis of T-cell receptor gamma chain expression in the thymus

Autor: Dm, Pardoll, Andrew Lew, Wl, Maloy, Bj, Fowlkes, Kruisbeek A, Ja, Bluestone, Rh, Schwartz, Je, Coligan

Publikováno v: Europe PubMed Central

While much is known about the structure and function of the T-cell receptor (TCR) alpha beta heterodimer, information has just begun to emerge about the gamma protein, the product of a third rearranging T-cell receptor gene. We describe the use of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c88096b12c093cea2827b75c120aadf7
http://europepmc.org/abstract/med/3453602

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response.

Autor: Han J; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Cherry C; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Mejías JC; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Krishnan K; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Ruta A; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Maestas DR Jr; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Peña AN; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Nguyen HH; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Nagaraj S; Department of Neurology, Brain Science Institute, Johns Hopkins University, Baltimore, MD, 21231, USA., Yang B; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Gray-Gaillard EF; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Rutkowski N; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Browne M; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA., Tam AJ; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Fertig EJ; Department of Biomedical Engineering and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21218, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, 21218, USA., Housseau F; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Ganguly S; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Moore EM; Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA., Pardoll DM; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Elisseeff JH; Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.

Publikováno v: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Oct; Vol. 36 (43), pp. e2310476. Date of Electronic Publication: 2023 Dec 28.

Radiation immunodynamics in patients with glioblastoma receiving chemoradiation.

Autor: Sloan L; Department of Radiation Oncology, University of Minnesota, Minneapolis, MN, United States.; University of Minnesota Medical School, University of Minnesota, Minneapolis, MN, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Sen R; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Liu C; Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Doucet M; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Blosser L; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Katulis L; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Kamson DO; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Brain Cancer Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Grossman S; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Brain Cancer Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Holdhoff M; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Brain Cancer Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Redmond KJ; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Quon H; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Lim M; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States., Eberhart C; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Pardoll DM; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Hu C; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, United States., Ganguly S; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Kleinberg LR; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Brain Cancer Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Sep 13; Vol. 15, pp. 1438044. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).