Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity

Autor: Dj, Morgan, Ht, Kreuwel, Fleck S, Hi, Levitsky, Dm, Pardoll, Linda Sherman

Publikováno v: Europe PubMed Central

To determine how self-tolerance can alter the ability of the immune system to respond against tumor-associated Ags that are also expressed by normal tissue, we designed experiments in which the same protein was expressed both as a tumor Ag and as a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f11fa4d1231e25b06d00a53e32ce5970
https://pubmed.ncbi.nlm.nih.gov/9551898

Thymus-dependent and thymus-independent developmental pathways for peripheral T cell receptor-gamma delta-bearing lymphocytes

Autor: Dm, Pardoll, Bj, Fowlkes, Andrew Lew, Wl, Maloy, Ma, Weston, Ja, Bluestone, Rh, Schwartz, Je, Coligan, Am, Kruisbeek

Publikováno v: Europe PubMed Central

To elucidate the developmental pathways of T cells that bear TCR gamma delta, we have analyzed the kinetics of expression and biochemical characteristics of gamma delta receptors in the thymus and spleen of normal and athymic (nude) mice, as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::300d1fc4e0c8d77525e3f16ea1ca2989
https://pubmed.ncbi.nlm.nih.gov/3259605

Analysis of T-cell receptor gamma chain expression in the thymus

Autor: Dm, Pardoll, Andrew Lew, Wl, Maloy, Bj, Fowlkes, Kruisbeek A, Ja, Bluestone, Rh, Schwartz, Je, Coligan

Publikováno v: Europe PubMed Central

While much is known about the structure and function of the T-cell receptor (TCR) alpha beta heterodimer, information has just begun to emerge about the gamma protein, the product of a third rearranging T-cell receptor gene. We describe the use of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c88096b12c093cea2827b75c120aadf7
http://europepmc.org/abstract/med/3453602

Synergistic combination therapy using cowpea mosaic virus intratumoral immunotherapy and Lag-3 checkpoint blockade.

Autor: Karan S; Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA., Jung E; Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA., Boone C; Department of Radiology, University of California, San Diego, La Jolla, CA, USA. ceboone@health.ucsd.edu., Steinmetz NF; Department of Nanoengineering, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Department of Radiology, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Shu and K.C. Chien and Peter Farrell Collaboratory, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Center for Nano-ImmunoEngineering, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Institute for Materials Discovery and Design, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.; Center for Engineering in Cancer, Institute of Engineering Medicine, University of California, San Diego, La Jolla, CA, USA. nsteinmetz@ucsd.edu.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2024 Feb 13; Vol. 73 (3), pp. 51. Date of Electronic Publication: 2024 Feb 13.

Melanoma Genomics and Immunotherapy.

Autor: CONSTANTINOU, MARIA¹ mconstantinou@lifespan.org

Publikováno v: Rhode Island Medical Journal. Nov2015, Vol. 98 Issue 11, p31-34. 4p.