Zobrazeno 1 - 10
of 759
pro vyhledávání: '"DM Goldenberg"'
Autor:
William A. Wegener, IA Mayer, Joyce A. O'Shaughnessy, R Iannone, RL Moroose, Linda T. Vahdat, DM Goldenberg, Aditya Bardia, SJ Isakoff, Robert M. Sharkey, Vandana G. Abramson, Kevin Kalinsky, Alessandro D. Santin, SA Washkowitz, Sara M. Tolaney, N. Shah, Jennifer R. Diamond, Dejan Juric
Publikováno v:
Cancer Research. 79:P2-11
Background: Sacituzumab govitecan is an antibody-drug conjugate consisting of SN-38, the active metabolite of irinotecan, conjugated to a humanized mAb targeting Trop-2 (trophoblastic antigen-2), which is highly expressed in many epithelial cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11293c3346076849cb4693e0093c2ac7
https://doi.org/10.1158/1538-7445.sabcs18-p2-11-01
https://doi.org/10.1158/1538-7445.sabcs18-p2-11-01
Autor:
Aditya Bardia, Joyce A. O'Shaughnessy, DM Goldenberg, Heather Horne, William A. Wegener, HS Rugo
Publikováno v:
Cancer Research. 78:OT2-07
Background: Metastatic TNBC has an aggressive course with limited therapy options and poor survival. Sacituzumab govitecan (IMMU-132) is a novel antibody drug conjugate consisting of SN-38, the active metabolite of the topoisomerase I inhibitor, irin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a19f47cdd1c06e34e8f40014cc28a31
https://doi.org/10.1158/1538-7445.sabcs17-ot2-07-05
https://doi.org/10.1158/1538-7445.sabcs17-ot2-07-05
Autor:
Sara M. Tolaney, Jennifer R. Diamond, Linda T. Vahdat, Aditya Bardia, IA Mayer, DM Goldenberg, Pius Maliakal, William A. Wegener, Kevin Kalinsky, SJ Isakoff, Alessandro D. Santin, N. Shah, Joyce A. O'Shaughnessy, Vandana G. Abramson, RL Moroose, Robert M. Sharkey, Serengulam V. Govindan
Publikováno v:
Cancer Research. 78:P1-12
This abstract was withdrawn by the authors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eed7bab0085a6c89a192c0c9c344e92e
https://doi.org/10.1158/1538-7445.sabcs17-p1-12-01
https://doi.org/10.1158/1538-7445.sabcs17-p1-12-01
Autor:
Linda T. Vahdat, IA Mayer, Alessandro D. Santin, Sara M. Tolaney, RL Moroose, Jennifer R. Diamond, DM Goldenberg, Pius Maliakal, N. Shah, Kevin Kalinsky, Robert M. Sharkey, Joyce A. O'Shaughnessy, SJ Isakoff, William A. Wegener, Serengulam V. Govindan, Aditya Bardia, Vandana G. Abramson
Publikováno v:
Cancer Research. 78:GS1-07
Background: mTNBC has an aggressive course with limited therapeutic options. Sacituzumab govitecan (IMMU-132) is a novel antibody drug conjugate consisting of SN-38, the active metabolite of the topoisomerase I inhibitor, irinotecan, conjugated to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7029bc8324b01dd0964b413ec6b41d64
https://doi.org/10.1158/1538-7445.sabcs17-gs1-07
https://doi.org/10.1158/1538-7445.sabcs17-gs1-07
Autor:
Diane L. Rossi, Thomas M. Cardillo, Ken Chang, DM Goldenberg, EA Rossi, Robert M. Sharkey, Ali Mostafa, Rongxiu Li
Publikováno v:
Cancer Research. 77:P6-14
Bispecific antibodies (bsAbs) for redirecting T cells to cancers have shown promise in both pre-clinical and clinical studies. However, clinical success has been minimal for solid cancers to-date. Previously, we reported highly effective T-cell redir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfaff91729ed8854a4c74bc993c897f1
https://doi.org/10.1158/1538-7445.sabcs16-p6-14-01
https://doi.org/10.1158/1538-7445.sabcs16-p6-14-01
Autor:
DM Goldenberg, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Maria Zalath, Thomas M. Cardillo
Publikováno v:
Cancer Research. 76:P6-15
Background: In current clinical trials (ClinicalTrials.gov, NCT01631552), triple-negative breast cancer (TNBC) patients treated with IMMU-132, which is composed of the active metabolite of irinotecan, SN-38, conjugated to an anti-Trop-2 antibody, sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdec30887555cb0940d90fae203a1bc
https://doi.org/10.1158/1538-7445.sabcs15-p6-15-02
https://doi.org/10.1158/1538-7445.sabcs15-p6-15-02
Publikováno v:
Cancer Research. 77:P2-04
Adoptive immunotherapy with chimeric antigen receptor (CAR)-engineered T or NK cells is in active clinical and preclinical development, with recent interest increasingly focused on advancing the availability of off-the-shelf allogeneic clonal NK cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa4934df1e3447136dfbf17ebf81d389
https://doi.org/10.1158/1538-7445.sabcs16-p2-04-17
https://doi.org/10.1158/1538-7445.sabcs16-p2-04-17
Autor:
EA Rossi, Robert M. Sharkey, DM Goldenberg, David V. Gold, Chien-Hsing Chang, William J. McBride, Thomas M. Cardillo, Habibe Karacay
Publikováno v:
Cancer Research. 68:4819-4826
Preclinical and clinical studies have demonstrated the application of radiolabeled mAb-PAM4 for nuclear imaging and radioimmunotherapy of pancreatic carcinoma. We have now examined the ability of a novel PAM4-based, bispecific monoclonal antibody (mA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72df95148d81c9cf31f5bd0371c26a29
https://doi.org/10.1158/0008-5472.can-08-0232
https://doi.org/10.1158/0008-5472.can-08-0232
Publikováno v:
Cancer Research. 71:P3-02
Background Combination therapy using two different monoclonal antibodies to achieve improved efficacy without increased toxicity is being pursued in various preclinical and clinical studies but, in principle, could be accomplished with a single bispe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21280430d7cc10495b5bb5daef1a44c1
https://doi.org/10.1158/0008-5472.sabcs11-p3-02-01
https://doi.org/10.1158/0008-5472.sabcs11-p3-02-01
Autor:
Rm Sharkey, Dm Goldenberg
Publikováno v:
International Journal of Oncology.
Cancer imaging with radiolabeled antibodies, or radioimmunodetection (RAID), has undergone a gradual multidisciplinary development over a period of at least 2 decades, resulting in rapid, simple, and accurate targeting agents that are now in final st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3156b0526afd0b67865ecec9969cb4
https://doi.org/10.3892/ijo.3.1.5
https://doi.org/10.3892/ijo.3.1.5