P.107 Personalized prediction of future lesion activity and treatment effect in multiple sclerosis from baseline MRI

Autor: JR Falet, J Durso-Finley, B Nichyporuk, DL Arnold, T Arbel

Publikováno v: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 49:S36-S36

Background: Precision medicine for multiple sclerosis (MS) involves choosing a treatment that best balances efficacy and disadvantages such as side effects, cost, and inconvenience, based on an individual’s unique characteristics. Machine learning

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea3e28d96b2bb712cc4497b3567d0daf
https://doi.org/10.1017/cjn.2022.201

The clinical usefulness of routine MRI assessment

Autor: Dl, Arnold, L, Stone

Publikováno v: International MS journal. 17(2)

Although the diagnostic value of magnetic resonance imaging (MRI) in multiple sclerosis (MS) is widely accepted, the clinical usefulness of routine MRI for monitoring the evolution of patients with MS is less widely accepted. It is not uncommon for c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8936363a7b619543689d02ad44efa70
https://pubmed.ncbi.nlm.nih.gov/21689499

Proton MR spectroscopy to assess axonal damage in multiple sclerosis and other white matter disorders

Autor: De Stefano N, Narayanan S, Pm, Matthews, Mortilla M, Mt, Dotti, antonio federico, Dl, Arnold

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Proton MR spectroscopy allows in vivo measurement of N-acetylaspartate in white matter, providing a biochemical index of axonal integrity. Several recent studies of patients with multiple sclerosis and other white matter disorders have shown both tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4fa37c8840d3e069ad178965a28b44d4
https://pubmed.ncbi.nlm.nih.gov/10871799

Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis.

Autor: Grasso EA; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Bloy L; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Kaplan P; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Bar-Or A; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Yeh EA; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Arnold DL; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Narayanan S; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Marrie RA; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Fadda G; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada., Banwell BL; From the Departments of Neurology (E.A.G., P.K., B.L.B.), Radiology (L.B.), Children's Hospital of Philadelphia, PA; Department of Neurology (A.B.-O.), University of Pennsylvania, PA; Division of Neurology (E.A.Y.), The Hospital for Sick Children, Toronto, Canada; McConnell Brain Imaging Centre (D.L.A.), Montreal Neurological Institute, Montreal, Canada; Department of Neurology (S.N.), McGill University, Montreal, Canada; Departments of Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; and Department of Medicine (G.F.), University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.

Publikováno v: Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2024 Nov; Vol. 11 (6), pp. e200319. Date of Electronic Publication: 2024 Oct 23.

Prognostic factors for worsening and improvement in multiple sclerosis using a multistate model.

Autor: Ocampo A; Novartis Pharma AG, Basel, Switzerland., Hatami F; Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Big Data Institute, University of Oxford, Oxford, UK., Čuklina J; Novartis Pharma AG, Basel, Switzerland., Graham G; Novartis Pharma AG, Basel, Switzerland., Ganjgahi H; Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Big Data Institute, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Sun Y; Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Big Data Institute, University of Oxford, Oxford, UK., Su W; Novartis Pharmaceuticals, East Hanover, NJ, USA., Mousseau MC; Novartis Ireland Ltd, Dublin, Ireland., Gardiner S; Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Big Data Institute, University of Oxford, Oxford, UK., Pendleton SC; Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Big Data Institute, University of Oxford, Oxford, UK., Aarden P; Novartis Pharma AG, Basel, Switzerland., Kieseier BC; Novartis Pharma AG, Basel, Switzerland., Arnold DL; McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada., Bermel RA; Mellen Center for Multiple Sclerosis, Department of Neurology, Cleveland Clinic, Cleveland, OH, USA., Häring DA; Novartis Pharma AG, Basel, Switzerland., Nichols TE; Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Big Data Institute, University of Oxford, Oxford, UK., Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2024 Oct; Vol. 30 (11-12), pp. 1455-1467. Date of Electronic Publication: 2024 Sep 28.