Výsledky vyhledávání

Comparison of two schedules of intermediate-dose methotrexate and cytarabine consolidation therapy for childhood B-precursor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

Autor: J J Shuster, DJ Pullen, Michael E. Harris, V J Land, Yaddanapudi Ravindranath, Robert A. Krance, D. Pinkel, W M Crist

Publikováno v: Journal of Clinical Oncology. 12:1939-1945

PURPOSE To compare efficacy and toxicity of two schedules of intermediate-dose methotrexate (IDM) and cytarabine (Ara-C) in remission consolidation of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS In 1986, the Pediatric Oncology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7e110e7aaaea1a339f2eb8d4be0d3f
https://doi.org/10.1200/jco.1994.12.9.1939

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Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study

Autor: Michael P. Link, Michael L. Cleary, N Hakami, DJ Pullen, Jeffrey E. Rubnitz, LS Frankel, Jonathan J. Shuster, Andrew J. Carroll

Publikováno v: Blood. 84:570-573

chromosome band 11q23, the location of the HRX gene, is a site of recurrent translocations in human malignancies. Infants with acute lymphoblastic leukemia (ALL) commonly have 11q23 translocations and have an especially poor prognosis despite intensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07411f1df6586497a746f731df13a4c1
https://doi.org/10.1182/blood.v84.2.570.570

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The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia

Autor: DJ Pullen, Susana C. Raimondi, Andrew J. Carroll, M. G. Hulshof, A. M. Curcio-Brint, David R. Head, P H Domer, T. A. Motroni, James R. Downing

Publikováno v: Blood. 83:330-335

The t(4;11)(q21;q23) is the most common translocation involving band 11q23 and is found predominantly in acute lymphoblastic leukemias (ALLs) of infants. Recent studies have shown that this translocation involves the MLL gene on chromosome 11 and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fed55753326fa02eecbe3027609ee5f
https://doi.org/10.1182/blood.v83.2.330.330

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Trisomy 21 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study (8602)

Autor: Jonathan J. Shuster, C. P. Steuber, Vita J. Land, DJ Pullen, Michael J. Borowitz, Andrew J. Carroll, Michael S. Watson, Frederick G. Behm

Publikováno v: Blood. 82:3098-3102

Of 1,036 children with newly diagnosed non-T, non-B acute lymphoblastic leukemia (ALL) and a demonstrated cytogenetic abnormality treated on the frontline Pediatric Oncology Group (POG) therapeutic trial 8602, there were 33 patients with trisomy 21 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dbec36a832b1e41d0de1fd134e4eccd
https://doi.org/10.1182/blood.v82.10.3098.bloodjournal82103098

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Predictability of the t(1;19)(q23;p13) from surface antigen phenotype: implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis: a Pediatric Oncology Group study

Autor: ML Cleary, AJ Carroll, DJ Pullen, JJ Shuster, Stephen P. Hunger, Michael J. Borowitz, CP Steuber

Publikováno v: Blood. 82:1086-1091

The t(1;19)(q23;p13) translocation occurs in approximately 5% of B- precursor acute lymphoblastic leukemias (ALLs) occurring in children. Its presence has been associated with a poor prognosis, which may be overcome with more intensive therapy. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cfd4a50ed9d1eec35424d49dae2a34
https://doi.org/10.1182/blood.v82.4.1086.bloodjournal8241086

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Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases [see comments]

Autor: CH Pui, LS Frankel, AJ Carroll, SC Raimondi, JJ Shuster, DR Head, WM Crist, VJ Land, DJ Pullen, CP Steuber

Publikováno v: Blood. 77:440-447

The t(4;11)(q21;q23) chromosomal abnormality was identified in 40 (2%) of 1,986 children with newly diagnosed acute lymphoblastic leukemia (ALL). This translocation was associated with female sex (63%), age less than 1 year (60%), hyperleukocytosis (

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https://doi.org/10.1182/blood.v77.3.440.bloodjournal773440

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Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

Autor: DJ Pullen, Frederick G. Behm, Jonathan J. Shuster, M Whitehead, A T Look, Andrew J. Carroll, William M. Crist, D Mahoney, A Ragab, T.J. Vietti

Publikováno v: Blood. 76:117-122

The prognostic significance of chromosomal translocations, particularly t(1;19) (q23;p13), was evaluated in children with pre-B and early pre-B acute lymphoblastic leukemia (ALL). Patients were treated on a risk- based protocol of the Pediatric Oncol

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https://doi.org/10.1182/blood.v76.1.117.117

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Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line

Autor: William M. Crist, C H Pui, VJ Land, DJ Pullen, Michael J. Borowitz, Frederick G. Behm, Jonathan J. Shuster, Dorothy L. Williams, Susana C. Raimondi, Andrew J. Carroll

Publikováno v: Blood. 75:1170-1177

Cytogenetic and DNA flow cytometric analyses of leukemic cells from 2,184 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 27 cases (1.2%) that had a hypodiploid line with fewer than 45 chromosomes per cell. Had cytogenetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49ecda0f4ec5d6a0d3f97c2fa70aed89
https://doi.org/10.1182/blood.v75.5.1170.bloodjournal7551170

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Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study

Autor: JE Rubnitz, MP Link, JJ Shuster, AJ Carroll, N Hakami, LS Frankel, DJ Pullen, ML Cleary

Publikováno v: Blood. 84(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c5807acf1264b0cf5b78907a6dd404
https://pubmed.ncbi.nlm.nih.gov/8025282

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Trisomy 21 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study (8602)

Autor: MS Watson, AJ Carroll, JJ Shuster, CP Steuber, MJ Borowitz, FG Behm, DJ Pullen, VJ Land

Publikováno v: Blood. 82(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0556e431b0955deae629893fd00cda
https://pubmed.ncbi.nlm.nih.gov/8219201

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