Zobrazeno 1 - 10
of 417
pro vyhledávání: '"DINO MORAS"'
Autor:
Brice Beinsteiner, Gabriel V. Markov, Maxime Bourguet, Alastair G. McEwen, Stéphane Erb, Abdul Kareem Mohideen Patel, Fatima Z. El Khaloufi El Khaddar, Claire Lecroisey, Guillaume Holzer, Karim Essabri, Isabelle Hazemann, Ali Hamiche, Sarah Cianférani, Dino Moras, Vincent Laudet, Isabelle M. L. Billas
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Nuclear receptors are transcription factors of central importance in human biology and associated diseases. Much of the knowledge related to their major functions, such as ligand and DNA binding or dimerization, derives from funct
Externí odkaz:
https://doaj.org/article/a92389b629514a4e8a6968a1a1cd396d
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor (NR) family that is expressed in liver, kidney, intestine and pancreas. It is a master regulator of liver-specific gene expression, in particular thos
Externí odkaz:
https://doaj.org/article/010d8580355b40078ae4111df27f9fe9
Autor:
Brice Beinsteiner, Gabriel V Markov, Stéphane Erb, Yassmine Chebaro, Alastair G McEwen, Sarah Cianférani, Vincent Laudet, Dino Moras, Isabelle M L Billas
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009492 (2021)
Nuclear receptors are ligand-activated transcription factors that modulate gene regulatory networks from embryonic development to adult physiology and thus represent major targets for clinical interventions in many diseases. Most nuclear receptors fu
Externí odkaz:
https://doaj.org/article/48e697a2f52f4e94a579272af3d6c135
Autor:
Tiphaine Huet, Gilles Laverny, Fabrice Ciesielski, Ferdinand Molnár, Thanuja Gali Ramamoorthy, Anna Y. Belorusova, Pierre Antony, Noelle Potier, Daniel Metzger, Dino Moras, Natacha Rochel
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)
The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding dom
Externí odkaz:
https://doaj.org/article/c1ca4632498449e98f431812cd05e383
Autor:
Kareem Mohideen-Abdul, Karima Tazibt, Maxime Bourguet, Isabelle Hazemann, Isabelle Lebars, Maria Takacs, Sarah Cianférani, Bruno P. Klaholz, Dino Moras, Isabelle M. L. Billas
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Most nuclear receptors (NRs) bind DNA as dimers, either as hetero- or as homodimers on DNA sequences organized as two half-sites with specific orientation and spacing. The dimerization of NRs on their cognate response elements (REs) involves specific
Externí odkaz:
https://doaj.org/article/19a2cb3e9d3b417cbd1630f4b448a509
Publikováno v:
BioTechniques, Vol 44, Iss 1, Pp 101-106 (2008)
In the past five years, Structural Genomics (SG) initiatives have established an automated pipeline for protein production in Escherichia coli to rapidly screen various conditions, resulting in soluble expression of recombinant proteins to aid in car
Externí odkaz:
https://doaj.org/article/32d29d21702b478cbb9627964e5d4142
Autor:
Maria Takacs, Maxim V Petoukhov, R Andrew Atkinson, Pierre Roblin, François-Xavier Ogi, Borries Demeler, Noelle Potier, Yassmine Chebaro, Annick Dejaegere, Dmitri I Svergun, Dino Moras, Isabelle M L Billas
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67810 (2013)
BackgroundPGC-1α is a crucial regulator of cellular metabolism and energy homeostasis that functionally acts together with the estrogen-related receptors (ERRα and ERRγ) in the regulation of mitochondrial and metabolic gene networks. Dimerization
Externí odkaz:
https://doaj.org/article/0645df87374045a1b9f15e0fba416ec9
Autor:
Benoit Maillot, Nicolas Lévy, Sylvia Eiler, Corinne Crucifix, Florence Granger, Ludovic Richert, Pascal Didier, Julien Godet, Karine Pradeau-Aubreton, Stéphane Emiliani, Alexis Nazabal, Paul Lesbats, Vincent Parissi, Yves Mely, Dino Moras, Patrick Schultz, Marc Ruff
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60734 (2013)
Integration of the HIV-1 cDNA into the human genome is catalyzed by the viral integrase (IN) protein. Several studies have shown the importance of cellular cofactors that interact with integrase and affect viral integration and infectivity. In this s
Externí odkaz:
https://doaj.org/article/ae47d79f1a22403bb64619739332bb21
Publikováno v:
PPAR Research, Vol 2012 (2012)
PPARγ is a key regulator of glucose homeostasis and insulin sensitization. PPARγ must heterodimerize with its dimeric partner, the retinoid X receptor (RXR), to bind DNA and associated coactivators such as p160 family members or PGC-1α to regulate
Externí odkaz:
https://doaj.org/article/37fafe4c9c85467caf1a2db477b8300a
Autor:
Ferdinand Molnár, Rita Sigüeiro, Yoshiteru Sato, Clarisse Araujo, Inge Schuster, Pierre Antony, Jean Peluso, Christian Muller, Antonio Mouriño, Dino Moras, Natacha Rochel
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18124 (2011)
BackgroundThe 1α,25-dihydroxy-3-epi-vitamin-D3 (1α,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcript
Externí odkaz:
https://doaj.org/article/25a28b670f684904a71dbf40fb88d15a