Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen

Autor: Eichenbaum, Gary, Yang, Kyunghee, Gebremichael, Yeshitila, Howell, Brett A., Murray, F. Jay, Jacobson-Kram, David, Jaeschke, Hartmut, Kuffner, Edwin, Gelotte, Cathy K., Lai, John C.K., Wikoff, Daniele, Atillasoy, Evren

Publikováno v: In Regulatory Toxicology and Pharmacology December 2020 118

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Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym^®, a Mechanistic Model of Drug-Induced Liver Injury.

Autor: Longo, DM^1,2, Yang, Y¹, Watkins, PB^1,2, Howell, BA^1,2, Siler, SQ^1,2

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Jan2016, Vol. 5 Issue 1, p31-39. 9p.

Quantitative Systems Toxicology and Drug Development: The DILIsym Experience.

Autor: Watkins PB; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, Institute for Drug Safety Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pwatkins@email.unc.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2486, pp. 181-196.

DILIsym: Quantitative systems toxicology impacting drug development

Autor: Paul B. Watkins

Publikováno v: Current Opinion in Toxicology. :67-73

DILIsym®, a quantitative systems toxicology model developed over the last decade by the drug-induced liver injury (DILI)-sim Initiative, has provided novel insights regarding mechanisms underlying drug-induced liver injury and why animal models some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb0e280911a9d2540efc3a42c3f5f7e
https://doi.org/10.1016/j.cotox.2020.06.003