Zobrazeno 1 - 10
of 18
pro vyhledávání: '"DILARA SAHIN"'
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104539- (2023)
Summary: Background: The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells. The ability of selectively engaging either of these effects has spurred interest in using IL-2 for immunotherapy of cancer
Externí odkaz:
https://doaj.org/article/6f24eb0b735344ddbb97e4d54971d983
Autor:
Dilara Sahin, Natalia Arenas-Ramirez, Matthias Rath, Ufuk Karakus, Monika Hümbelin, Merel van Gogh, Lubor Borsig, Onur Boyman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a
Externí odkaz:
https://doaj.org/article/bccae141645e49d6828a1fe5efe66a25
The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy
Autor:
Daniel Zingg, Natalia Arenas-Ramirez, Dilara Sahin, Rodney A. Rosalia, Ana T. Antunes, Jessica Haeusel, Lukas Sommer, Onur Boyman
Publikováno v:
Cell Reports, Vol 20, Iss 4, Pp 854-867 (2017)
Immunotherapy and particularly immune checkpoint inhibitors have resulted in remarkable clinical responses in patients with immunogenic tumors, although most cancers develop resistance to immunotherapy. The molecular mechanisms of tumor resistance to
Externí odkaz:
https://doaj.org/article/967779b6723443cdb0ae74f91c533240
Autor:
Maria Antsiferova, Aleksandra Piwko‐Czuchra, Michael Cangkrama, Mateusz Wietecha, Dilara Sahin, Katharina Birkner, Valerie C Amann, Mitchell Levesque, Daniel Hohl, Reinhard Dummer, Sabine Werner
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 1, Pp 27-45 (2016)
Abstract Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functional
Externí odkaz:
https://doaj.org/article/8b489d48e3b74bdda947d60c4b576bef
Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias and tissue-targeting properties. Several of these compounds are cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eb34348255a653686d305bf74ae467
https://www.zora.uzh.ch/id/eprint/229260/
https://www.zora.uzh.ch/id/eprint/229260/
Publikováno v:
Journal of paediatrics and child healthReferences. 58(9)
Our study aims to analyse the effect of using a vacutainer with cartoon characters on preschoolers' pain and fear levels during the bloodletting process.The experimental, randomised controlled clinical trial was conducted with 102 children aged 3-6 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73027f5a32013a7cbff32ad42347750c
https://pubmed.ncbi.nlm.nih.gov/35657084
https://pubmed.ncbi.nlm.nih.gov/35657084
Publikováno v:
Science Translational Medicine. 12
Stimulation of regulatory T (Treg) cells holds great promise for the treatment of autoimmune, chronic inflammatory, and certain metabolic diseases. Recent clinical trials with low-dose interleukin-2 (IL-2) to expand Treg cells led to beneficial resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1f0fcc676d0081e0af1c7ff7c4dffa
https://doi.org/10.1126/scitranslmed.abb9283
https://doi.org/10.1126/scitranslmed.abb9283
Autor:
Jürg Hafner, Onur Boyman, Antonios G.A. Kolios, Dilara Sahin, Dennis Kurzbach, Daniela Impellizzieri, Ge Tan, Nikhil Yawalkar, Jakob Nilsson, Tuan T. Nguyen, Alaz Özcan, Cezmi A. Akdis
Publikováno v:
Özcan, Alaz; Sahin, Dilara; Impellizzieri, Daniela; Nguyen, Tuan T; Hafner, Jürg; Yawalkar, Nikhil; Kurzbach, Dennis; Tan, Ge; Akdis, Cezmi A; Nilsson, Jakob; Boyman, Onur; Kolios, Antonios G A (2020). Nanoparticle-coupled topical methotrexate can normalize immune responses and induce tissue remodeling in psoriasis. Journal of investigative dermatology, 140(5), 1003-1014.e8. Elsevier 10.1016/j.jid.2019.09.018
Methotrexate (MTX) is an antiproliferative drug used for treating inflammatory diseases, including psoriasis. Nevertheless, its use in localized therapy is hindered because of poor transdermal penetration. We show that MTX coupled with gold nanoparti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20bbe002b592d35c5857cb0119e3129
https://www.zora.uzh.ch/id/eprint/177238/
https://www.zora.uzh.ch/id/eprint/177238/
Autor:
Dilara Sahin, Rabia Meryem Yilmaz
Publikováno v:
Computers & Education. 144:103710
This study aims to investigate the impact of learning materials developed with augmented reality (AR) technology on middle school students' achievement and attitudes towards the course, and to determine their attitudes towards AR applications. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d70d6d2c284921d5374ee2f8bf54a78
https://doi.org/10.1016/j.compedu.2019.103710
https://doi.org/10.1016/j.compedu.2019.103710
Autor:
Merve Özcan Türkmen, Aslı Çelebi Tayfur, Aysun Çaltik Yilmaz, Tugce Karaduman, Hatice Mergen, Ayşe Derya Buluş, Bahar Büyükkaragöz, Dilara Sahin
Publikováno v:
Journal of Clinical Research in Pediatric Endocrinology.
Objective Congenital nephrogenic diabetes insipidus (CNDI) is a rare inherited disorder characterized by a renal insensitivity to arginine vasopressin (AVP). In the majority of the cases, CNDI is caused by mutations in the arginine vasopressin recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2859f7f4b33852c72a568383c82478db
https://doi.org/10.4274/jcrpe.0097
https://doi.org/10.4274/jcrpe.0097