Zobrazeno 1 - 10
of 31
pro vyhledávání: '"DIG, digoxigenin"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 689-704 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Fifty percent of colorectal cancers show elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and are associated with inflammation, metastasis, and poor patient outcome. EMAST results from interleukin 6–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce37a4540c8c979dadfb468ba9d3a9b
https://doi.org/10.1016/j.jcmgh.2020.01.006
https://doi.org/10.1016/j.jcmgh.2020.01.006
Autor:
Daijiro Chiba, Yuka Jinno, Måns Aspåker, Natsuki Eguchi, Masaki Hashimoto, Risa Mori-Kreiner, Atsuo Nishino, Takafumi Kawai, Junko M. Nishino, Akira Kawanabe, Yukio Ohtsuka, Yasushi Okamura
Publikováno v:
The Journal of Biological Chemistry
Voltage-gated sodium channels (Nav1s) are responsible for the initiation and propagation of action potentials in neurons, muscle, and endocrine cells. Many clinically used drugs such as local anesthetics and antiarrhythmics inhibit Nav1s, and a varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9518a87f22f41224fcbde20eff4edff
http://europepmc.org/articles/PMC8192821
http://europepmc.org/articles/PMC8192821
Publikováno v:
The Journal of Biological Chemistry
Mammalian mitochondrial tRNA (mt-tRNA) plays a central role in the synthesis of the 13 subunits of the oxidative phosphorylation complex system (OXPHOS). However, many aspects of the context-dependent expression of mt-tRNAs in mammals remain unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3aca978eefcaea51571eb37b4380ba6
https://pubmed.ncbi.nlm.nih.gov/34265302
https://pubmed.ncbi.nlm.nih.gov/34265302
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101156-(2021)
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101156-(2021)
The salmon louse, Lepeophtheirus salmonis is an ectoparasite of salmonid fish in the Northern Hemisphere, causing large economical losses in the aquaculture industry and represent a threat to wild populations of salmonids. Like other oviparous animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f937b8eae31e460621ef95f9060d7f
https://hdl.handle.net/11250/2826090
https://hdl.handle.net/11250/2826090
Autor:
Bhushan Thakur, Kazuho Ishine, Noriaki Shimizu, Mirit I. Aladjem, Ryonosuke Taniguchi, Koichi Utani
Publikováno v:
The Journal of Biological Chemistry
Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697d87c6d27734a17d75a753638578c9
https://pubmed.ncbi.nlm.nih.gov/33539925
https://pubmed.ncbi.nlm.nih.gov/33539925
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 425-431 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Excess telomere shortening has been observed in most cancer cells. The telomere quantitative polymerase chain reaction (qPCR) assay has become an important tool for epidemiological studies examining the effects of aging, stress, and other factors on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1823b3d85a6600cd70db2ebe7797e5b
https://doi.org/10.1016/j.neo.2018.02.007
https://doi.org/10.1016/j.neo.2018.02.007
Publikováno v:
Biochemical Journal
Co- and post-translational N-myristoylation is known to play a role in the correct subcellular localization of specific proteins in eukaryotes. The enzyme that catalyses this reaction, NMT (N-myristoyltransferase), has been pharmacologically validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e221da5710d12167ceab56ea04a440e
http://europepmc.org/articles/PMC3969225
http://europepmc.org/articles/PMC3969225
Autor:
Hiroshi Kohriki, Hisako Ishige, Tetsuya Kohsaka, Masatoshi Shibata, Enoch Y. Park, Masafumi Fukuda, Itaru Minagawa, Tatsuo Kawarasaki
Publikováno v:
Biochemical Journal
RLF (relaxin-like factor), also known as INSL3 (insulin-like peptide 3), is a novel member of the relaxin/insulin gene family that is expressed in testicular Leydig cells. Despite the implicated role of RLF/INSL3 in testis development, its native con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a4822de568999b468321d9cff0d22b
https://doi.org/10.1042/bj20111107
https://doi.org/10.1042/bj20111107
Autor:
Maria Deak, Dario R. Alessi, Nicolas Dzamko, Fayçal Hentati, Alan R. Prescott, R. Jeremy Nichols, Alastair D. Reith
Publikováno v:
Biochemical Journal
LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients. Since a common mutation that replaces Gly2019 with a serine residue enhances kinase catalytic activity, small-molecule LRRK2 inhibitors m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71374cd2d22b2908102a9ec439d4eb39
https://doi.org/10.1042/bj20100784
https://doi.org/10.1042/bj20100784
Autor:
Alan R. Prescott, R. Jeremy Nichols, Jie Shen, Nicholas A. Morrice, Thomas Macartney, Maria Deak, David G. Campbell, Alban Ordureau, Nicolas Dzamko, Youren Tong, Dario R. Alessi
Publikováno v:
Biochemical Journal
LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of Parkinson's disease patients, but still little is understood about how it is regulated or functions. In the present study we have demonstrated that 14-3-3 protein isof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6152e2f8a47aec72b0dea7ed1955ec87
https://doi.org/10.1042/bj20100483
https://doi.org/10.1042/bj20100483