Zobrazeno 1 - 10
of 367
pro vyhledávání: '"DIETMAR VESTWEBER"'
Autor:
Rebekka I. Stegmeyer, Katrin Holstein, Kathleen Spring, Ilse Timmerman, Min Xia, Malte Stasch, Tanja Möller, Astrid F. Nottebaum, Dietmar Vestweber
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
C-terminal Src kinase (Csk) targets Src family kinases (SFKs) and thereby inactivates them. We have previously shown that Csk binds to phosphorylated tyrosine 685 of VE-cadherin, an adhesion molecule of major importance for the regulation of endothel
Externí odkaz:
https://doaj.org/article/cc466cdba736482a9b3684613f26b969
Autor:
Min Xia, Rebekka I. Stegmeyer, Keisuke Shirakura, Stefan Butz, Aude Thiriot, Ulrich H. von Andrian, Dietmar Vestweber
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Circulating leukocytes enter tissue either through endothelial junctions (paracellular) or via a pore through the body of endothelial cells (transcellular). We have previously shown that genetically replacing VE-cadherin with a VE-cadherin-
Externí odkaz:
https://doaj.org/article/d7024f1ba2364913a1a90f13e6ae4572
Autor:
Josephine A. Mapunda, Javier Pareja, Mykhailo Vladymyrov, Elisa Bouillet, Pauline Hélie, Petr Pleskač, Sara Barcos, Johanna Andrae, Dietmar Vestweber, Donald M. McDonald, Christer Betsholtz, Urban Deutsch, Steven T. Proulx, Britta Engelhardt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Meninges cover the surface of the brain and spinal cord and contribute to protection and immune surveillance of the central nervous system (CNS). How the meningeal layers establish CNS compartments with different accessibility to immune cell
Externí odkaz:
https://doaj.org/article/5001417dcd594d5dbe23e663b3f0fc45
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration
Autor:
Keisuke Shirakura, Peter Baluk, Astrid F Nottebaum, Ute Ipe, Kevin G Peters, Donald M McDonald, Dietmar Vestweber
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-23 (2023)
Abstract Vascular endothelial protein tyrosine phosphatase (VE‐PTP) influences endothelial barrier function by regulating the activation of tyrosine kinase receptor Tie2. We determined whether this action is linked to the development of atheroscler
Externí odkaz:
https://doaj.org/article/6fec18acacae4392945db5159ce762d7
Autor:
Eunhyeong Lee, Eun-Ah Lee, Eunji Kong, Haemin Chon, Melissa Llaiqui-Condori, Cheon Ho Park, Beom Yong Park, Nu Ri Kang, Jin-San Yoo, Hyun-Soo Lee, Hyung-Seok Kim, Sung-Hong Park, Seung-Won Choi, Dietmar Vestweber, Jeong Ho Lee, Pilhan Kim, Weon Sup Lee, Injune Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 470-484 (2023)
Brain tumours: antibody blocks blood vessel abnormality An antibody targeting key signalling pathways could prevent brain tumor vessels from being abnormal, thereby improving drug delivery into tumor tissues. Glioblastoma multiforme is considered one
Externí odkaz:
https://doaj.org/article/7679f0e3c99440579fb6c60a6fb0e645
Autor:
Katharina Thomas, Lisa Zondler, Nadine Ludwig, Marina Kardell, Corinna Lüneburg, Katharina Henke, Sina Mersmann, Andreas Margraf, Tilmann Spieker, Tobias Tekath, Ana Velic, Richard Holtmeier, Juliane Hermann, Vera Jankowski, Melanie Meersch, Dietmar Vestweber, Martin Westphal, Johannes Roth, Michael A. Schäfers, John A. Kellum, Clifford A. Lowell, Jan Rossaint, Alexander Zarbock
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI), we show that glutamine significantly
Externí odkaz:
https://doaj.org/article/30ea337b9c5d4c7ea8eab77560c841db
Autor:
Zhenhan Li, Nadine Ludwig, Katharina Thomas, Sina Mersmann, Martin Lehmann, Dietmar Vestweber, Jean-Francois Pittet, Hernando Gomez, John A. Kellum, Jan Rossaint, Alexander Zarbock
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acute kidney injury (AKI) may be induced by different causes, including renal ischemia-reperfusion injury and sepsis, which represent the most common reasons for AKI in hospitalized patients. AKI is defined by reduced urine production and/or increase
Externí odkaz:
https://doaj.org/article/643a80cce42f42a292654931518c71c2
Autor:
Kevin Brulois, Anusha Rajaraman, Agata Szade, Sofia Nordling, Ania Bogoslowski, Denis Dermadi, Milladur Rahman, Helena Kiefel, Edward O’Hara, Jasper J. Koning, Hiroto Kawashima, Bin Zhou, Dietmar Vestweber, Kristy Red-Horse, Reina E. Mebius, Ralf H. Adams, Paul Kubes, Junliang Pan, Eugene C. Butcher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The origin and diversity of blood vascular endothelial cells (BEC) in lymphoid tissues is unclear. Here, the authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell rec
Externí odkaz:
https://doaj.org/article/45437c711e144229ae3255403b2c7df7
Autor:
Takeshi Ninchoji, Dominic T Love, Ross O Smith, Marie Hedlund, Dietmar Vestweber, William C Sessa, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 10 (2021)
Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. Method
Externí odkaz:
https://doaj.org/article/22d057117123401086a68b774154e78c
Autor:
Maike Frye, Simon Stritt, Henrik Ortsäter, Magda Hernandez Vasquez, Mika Kaakinen, Andres Vicente, John Wiseman, Lauri Eklund, Jorge L Martínez-Torrecuadrada, Dietmar Vestweber, Taija Mäkinen
Publikováno v:
eLife, Vol 9 (2020)
Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier function of collecting lymphatic vessels is also important
Externí odkaz:
https://doaj.org/article/511cd356e48f4432812f872668cb390a