Zobrazeno 1 - 10
of 57
pro vyhledávání: '"DICK, J. H."'
Autor:
Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Lysosomes play an important role in cellular LDL-cholesterol uptake. Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL trafficking an
Externí odkaz:
https://doaj.org/article/5ea86788f5ff452193f198cb9ba6bdd4
Autor:
van den Boomen, Dick J. H., Timms, Richard T., Grice, Guinevere L., Stagg, Helen R., Skødt, Karsten, Dougan, Gordon, Nathan, James A., Lehner, Paul J.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2014 Aug 01. 111(31), 11425-11430.
Externí odkaz:
https://www.jstor.org/stable/23805809
Autor:
Burr, Marian L., van den Boomen, Dick J. H., Bye, Helen, Antrobus, Robin, Wiertz, Emmanuel J., Lehner, Paul J.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2013 Aug . 110(35), 14290-14295.
Externí odkaz:
https://www.jstor.org/stable/42713092
Publikováno v:
Current Opinion in Cell Biology. 65:103-111
Cholesterol is an essential component of mammalian membranes, and its homeostasis is strictly regulated, with imbalances causing atherosclerosis, Niemann Pick disease, and familial hypercholesterolemia. Cellular cholesterol supply is mediated by LDL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b241f5871b5fe27af964aff0bf8b8b5
https://doi.org/10.1016/j.ceb.2020.04.010
https://doi.org/10.1016/j.ceb.2020.04.010
Autor:
Jye-Lin Hsu, Dick J H van den Boomen, Peter Tomasec, Michael P Weekes, Robin Antrobus, Richard J Stanton, Eva Ruckova, Daniel Sugrue, Gavin S Wilkie, Andrew J Davison, Gavin W G Wilkinson, Paul J Lehner
Publikováno v:
PLoS Pathogens, Vol 11, Iss 4, p e1004811 (2015)
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond M
Externí odkaz:
https://doaj.org/article/d057a00df10f4bbdb235d95e59e2cbce
Autor:
Ilana Berlin, Agata Sienkiewicz, Paul J. Lehner, Dick J. H. van den Boomen, Marlieke L.M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques Neefjes
Publikováno v:
Nature Communications
Nature Communications, 11(1). NATURE RESEARCH
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 11(1). NATURE RESEARCH
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2d8cd870120ef7d7703dbb0df2c6f0
Akademický článek
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Akademický článek
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Autor:
Hsu, Jye-Lin1, van den Boomen, Dick J. H.1, Weekes, Michael P.1, Antrobus, Robin1, Lehner, Paul J.1, Tomasec, Peter2, Stanton, Richard J.2, Sugrue, Daniel2, Wilkinson, Gavin W. G.2, Ruckova, Eva3, Wilkie, Gavin S.4, Davison, Andrew J.4
Publikováno v:
PLoS Pathogens. Apr2015, Vol. 11 Issue 4, p1-24. 24p.
Autor:
Dick J. H. van den Boomen, James A. Nathan, Anna S Dickson, Richard T. Timms, Paul J. Lehner, Norbert Volkmar, Sam A. Menzies
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a987de26e34bf8224ce1d2293950d5
https://elifesciences.org/articles/40009
https://elifesciences.org/articles/40009