Zobrazeno 1 - 10
of 105
pro vyhledávání: '"DHTKD1"'
Akademický článek
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Autor:
Alexandra I. Boyko, Irina S. Karlina, Lev G. Zavileyskiy, Vasily A. Aleshin, Artem V. Artiukhov, Thilo Kaehne, Alexander L. Ksenofontov, Sergey I. Ryabov, Anastasia V. Graf, Angela Tramonti, Victoria I. Bunik
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundThe DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly low and cell-specific flux through these pathways, and similar activities of OADH and ubi
Externí odkaz:
https://doaj.org/article/c348e03e0bc340388c2b955d9ea9932f
Autor:
Victoria I. Bunik, Artem V. Artiukhov, Alexey V. Kazantsev, Vasily A. Aleshin, Alexandra I. Boyko, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) and 2-oxoadipate (OADH, encoded by DHTKD1), respectively. To assess the selectivit
Externí odkaz:
https://doaj.org/article/ae420945964148f7aeda0e9e80f8ae1c
Autor:
Gustavo A. Bezerra, William R. Foster, Henry J. Bailey, Kevin G. Hicks, Sven W. Sauer, Bianca Dimitrov, Thomas J. McCorvie, Jürgen G. Okun, Jared Rutter, Stefan Kölker, Wyatt W. Yue
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 693-706 (2020)
DHTKD1 is a lesser-studied E1 enzyme among the family of 2-oxoacid dehydrogenases. In complex with E2 (dihydrolipoamide succinyltransferase, DLST) and E3 (dihydrolipoamide dehydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan ca
Externí odkaz:
https://doaj.org/article/f5c7b911e55a49b5ba415171e6dd2ab1
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Cardiometabolic disease affects the majority of individuals worldwide. The metabolite α-aminoadipic acid (2-AAA) was identified as a biomarker of Type 2 Diabetes (T2D). However, the mechanisms underlying this association remain unknown. DHTKD1, a ce
Externí odkaz:
https://doaj.org/article/d89bc734312a4eefb8c914b99312bf57
Autor:
Artem V. Artiukhov, Alexey V. Kazantsev, Nikolay V. Lukashev, Marco Bellinzoni, Victoria I. Bunik
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
Phosphonate analogs of pyruvate and 2-oxoglutarate are established specific inhibitors of cognate 2-oxo acid dehydrogenases. The present work develops application of this class of compounds to specific in vivo inhibition of 2-oxoglutarate dehydrogena
Externí odkaz:
https://doaj.org/article/5fd87f66377a4f6cb10e574da53f1be2
Autor:
Dulce M. Castro-Coyotl, Israel E. Crisanto-López, Rosa M. Hernández-Camacho, María P. Saldaña-Guerrero
Publikováno v:
Boletín Médico del Hospital Infantil de México, Vol 78, Iss 5 (2021)
Background: Charcot-Marie-Tooth disease type 2Q (CMT2Q) is a rare disorder (< 1/1,000,000 individuals worldwide) linked to chromosome 10p14 in the DHTKD1 gene. This phenotype is characterized by an adolescent or adulthood-onset, slowly progressive di
Externí odkaz:
https://doaj.org/article/7011c9a7d3604ff3bf84740d3a907bfb
Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Wyatt W. Yue, Thomas J. McCorvie, Bianca Dimitrov, Henry J. Bailey, Kevin G. Hicks, Stefan Kölker, Sven W. Sauer, Gustavo Arruda Bezerra, Juergen G. Okun, W. Foster, Jared Rutter
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 693-706 (2020)
IUCrJ
IUCrJ
Through interaction studies, the crystal structure of human DHTKD1 allows insight into a mitochondrial megacomplex in lysine catabolism. This creates the starting framework for developing DHTKD1 modulators to probe the intricate mitochondrial energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6477f2f702f20628cd60b07635802f1
https://doi.org/10.1107/s205225252000696x
https://doi.org/10.1107/s205225252000696x