Zobrazeno 1 - 6
of 6
pro vyhledávání: '"DHR2 domain"'
Publikováno v:
The Journal of Biological Chemistry
The human dedicator of cytokinesis (DOCK) family consists of 11 structurally conserved proteins that serve as atypical RHO guanine nucleotide exchange factors (RHO GEFs). These regulatory proteins act as mediators in numerous cellular cascades that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6616905efc2a2ef77da8d684aca0b
http://europepmc.org/articles/PMC8063744
http://europepmc.org/articles/PMC8063744
Publikováno v:
The Journal of biological chemistry. 286(28)
DOCK (dedicator of cytokinesis) guanine nucleotide exchange factors (GEFs) activate the Rho-family GTPases Rac and Cdc42 to control cell migration, morphogenesis, and phagocytosis. The DOCK A and B subfamilies activate Rac, whereas the DOCK D subfami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec15a96595a1607317bf201f1af73f98
https://pubmed.ncbi.nlm.nih.gov/21613211
https://pubmed.ncbi.nlm.nih.gov/21613211
Publikováno v:
The Journal of biological chemistry. 281(46)
Cdc42, a member of the Rho subfamily of small GTPases, influences a wide range of activities including the establishment of cell polarity, migration, and the regulation of cell growth and differentiation. Here we describe the identification of an app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2870771cffb538c89a975e8d4d85cdb4
https://pubmed.ncbi.nlm.nih.gov/16968698
https://pubmed.ncbi.nlm.nih.gov/16968698
Publikováno v:
Journal of cell science. 118(Pt 21)
The Rho family of small GTPases are important regulators of multiple cellular activities and, most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain-containing proteins are the classical guanine nucleotide exchange factors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad843863b8ee6af7016c77572aa6300b
https://pubmed.ncbi.nlm.nih.gov/16254241
https://pubmed.ncbi.nlm.nih.gov/16254241
Autor:
Kodi S. Ravichandran, Mingjian Lu
Publikováno v:
Proteins and Cell Regulation ISBN: 140203461X
Members of the Dock180 superfamily of proteins have been recently identified as novel guanine nucleotide exchange factors (GEF) for Rho family of small GTPases. While conventional GEFs use a conserved DH-PH cassette for catalyzing GTP/GDP nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3437628e75af512ef8a74dfd516afc3
https://doi.org/10.1007/1-4020-3462-8_4
https://doi.org/10.1007/1-4020-3462-8_4
Publikováno v:
Scientific Reports.
Rac small GTPases and their GEFs of the DOCK family are pivotal checkpoints in development, autoimmunity and bone homeostasis, and their abnormal regulation is associated to diverse pathologies. Small molecules that inhibit their activities are there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6e6ef2f8d59e28c7a1a980c61e5a43