Zobrazeno 1 - 10
of 1 430
pro vyhledávání: '"DHPS"'
Autor:
Kevin Schofield, Shayna Maddern, Yueteng Zhang, Grace E. Mastin, Rachel Knight, Wei Wang, James Galligan, Christopher Hulme
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2270-2279 (2024)
The utility of bio-isosteres is broad in drug discovery and methodology herein enables the preparation of deuterium-labeled products is the most fundamental of known bio-isosteric replacements. As such we report the use of both [D1]-aldehydes and [D2
Externí odkaz:
https://doaj.org/article/faf573af030a4151bcf777a1b3ca1748
Autor:
Paola Cavalli, Anna Raffauf, Sergio Passarella, Martin Helmuth, Daniela C. Dieterich, Peter Landgraf
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Deoxyhypusine synthase (DHPS) catalyzes the initial step of hypusine incorporation into the eukaryotic initiation factor 5A (eIF5A), leading to its activation. The activated eIF5A, in turn, plays a key role in regulating the protein translation of se
Externí odkaz:
https://doaj.org/article/31694ed27f8c40a49965efb62181abbd
Autor:
Jing‐si Guo, Jian Ma, Xi‐he Zhao, Ji‐fang Zhang, Kai‐li Liu, Long‐tian Li, Yu‐xi Qin, Fan‐hao Meng, Ling‐yan Jian, Yue‐hui Yang, Xin‐yang Li
Publikováno v:
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024)
Abstract Discovering new treatments for melanoma will benefit human health. The mechanism by which deoxyhypusine synthase (DHPS) promotes melanoma development remains elucidated. Multi‐omics studies have revealed that DHPS regulates m6A modificatio
Externí odkaz:
https://doaj.org/article/eb2b497ad4e140778cece06538c92a0e
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Despite the updated guidelines on dental impression disinfection protocols during the COVID-19 pandemic, adherence to such procedures has not been studied among dental health professionals in Saudi Arabia. Understanding DHPs’ kn
Externí odkaz:
https://doaj.org/article/36d2106c3c9b4758a1cca8e7822e3bbb
Autor:
Sawadogo H, Soulama I, Zida A, Zongo C, Sawadogo PM, Guiguemde KT, Nikiema S, Badoum SE, Sawadogo S, Tou A, Sombié S, Tchekounou C, Sermé SS, Ouedraogo-Traoré R, Guiguemdé TR, Savadogo A
Publikováno v:
Infection and Drug Resistance, Vol Volume 16, Pp 6673-6680 (2023)
Haffsatou Sawadogo,1,2 Issiaka Soulama,3,4 Adama Zida,2,5 Cheikna Zongo,1 Patindoilba Marcel Sawadogo,2,5 Kiswendsida Thierry Guiguemde,5,6 Seni Nikiema,7 Salimata Emilie Badoum,1,8 Salam Sawadogo,7 Aïcha Tou,4 Salif Sombié,4 Chanolle Tchekounou,1,
Externí odkaz:
https://doaj.org/article/4c40f0cd40ed4ecf84b987f4caa33569
Autor:
Aline Zaparte, Courtney J. Christopher, Connie Arnold, Lauren Richey, Adairre Castille, Kyle Mistretta, Christopher M. Taylor, Huiyi Lin, Steve Nelson, John P. Kirwan, John W. Apolzan, Shawn R. Campagna, David A. Welsh
Publikováno v:
Metabolites, Vol 14, Iss 8, p 434 (2024)
The popularity of e-cigarettes (vaping) has soared, creating a public health crisis among teens and young adults. Chronic vaping can induce gut inflammation and reduce intestinal barrier function through the production of the proinflammatory molecule
Externí odkaz:
https://doaj.org/article/903f95c54b4443408f244476ca6c3b09
Autor:
Harry F. Mbacham, Diange M Mosume, Tobias O. Apinjoh, Vincent N. Ntui, Marcel N. Moyeh, Laken N. Kalaji, Godlove B. Wepnje, Stephen M Ghogomu, Jodie A Dionne, Alan T.N. Tita, Eric A. Achidi, Judith K. Anchang-Kimbi
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background Plasmodium falciparum resistance to intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) continues to spread throughout sub-Saharan Africa. This study assessed the occurrence of microscopic and sub-microscopi
Externí odkaz:
https://doaj.org/article/0406446ade9445a99df85c19286a6111
Autor:
Leah R. Padgett, Mollie R. Shinkle, Spencer Rosario, Tracy Murray Stewart, Jackson R. Foley, Robert A. Casero, Jr., Myung Hee Park, Wendy K. Chung, Teresa L. Mastracci
Publikováno v:
HGG Advances, Vol 4, Iss 3, Pp 100206- (2023)
Summary: DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore acti
Externí odkaz:
https://doaj.org/article/e7637e4d3aca4a68831a2b5aa9c94073
Autor:
Ahmed Saif
Publikováno v:
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 2, Pp 72-79 (2023)
Objective: To determine the genetic diversity, natural selection and mutations in Plasmodium (P.) knowlesi drug resistant molecular markers Kelch 13 and dhps gene in clinical samples of Malaysia. Methods: P. knowlesi full-length gene sequences Kelch
Externí odkaz:
https://doaj.org/article/cdb1177530974f3a9c0707dd29ef710e
Autor:
Zhiyong Zhou, John E. Gimnig, Sheila B. Sergent, Ying Liu, Bernard Abong’o, Kephas Otieno, Winnie Chebore, Monica P. Shah, John Williamson, Feiko O. ter Kuile, Mary J. Hamel, Simon Kariuki, Meghna Desai, Aaron M. Samuels, Edward D. Walker, Ya Ping Shi
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background Over the last two decades, the scale-up of vector control and changes in the first-line anti-malarial, from chloroquine (CQ) to sulfadoxine-pyrimethamine (SP) and then to artemether-lumefantrine (AL), have resulted in significant
Externí odkaz:
https://doaj.org/article/62be807a634a4d2a9a87bd36ea838a4c