Zobrazeno 1 - 10
of 640
pro vyhledávání: '"DHODH"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract High-grade B-cell lymphoma (HGBCL), the subtype of non-Hodgkin lymphoma, to be relapsed or refractory in patients after initial therapy or salvage chemotherapy. Dual dysregulation of MYC and BCL2 is one of the important pathogenic mechanisms
Externí odkaz:
https://doaj.org/article/b2e63d2e364d46c0b5e25a19a5ad1487
Autor:
Nan‐Nan Liang, Yue‐Yue Guo, Xiao‐Yi Zhang, Ya‐Hui Ren, Yi‐Zhang He, Zhi‐Bing Liu, De‐Xiang Xu, Shen Xu
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract Several studies have observed renal cell ferroptosis during cisplatin‐induced acute kidney injury (AKI). However, the mechanism is not completely clear. In this study, oxidized arachidonic acid (AA) metabolites are increased in cisplatin
Externí odkaz:
https://doaj.org/article/5543bbdda8d04a4d81e266736cacbfc4
Autor:
Songsong Wang, Yan Li, Yilong Lin, Junting Li, Lang Guo, Haoyu Wang, Xinyuan Lin, Ziming Liu, Bingqi Zhang, Zhengming Liao, Zhongmin Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular characteristics using public databases. TCGA pan-cancer dataset was used to
Externí odkaz:
https://doaj.org/article/87aee07e8a134dfe9049fb5e2f4ab0b2
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 3, Pp 216-219 (2024)
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxid
Externí odkaz:
https://doaj.org/article/f92bcab43ab54bbbaeaeaf08dcc57777
Autor:
Nicholas J Mullen, Surendra K Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Juan F Santana, William R Miklavcic, Drew A LaBreck, Jayapal Reddy Mallareddy, David H Price, Amarnath Natarajan, Kamiya Mehla, David B Sykes, Michael A Hollingsworth, Pankaj K Singh
Publikováno v:
eLife, Vol 12 (2024)
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzym
Externí odkaz:
https://doaj.org/article/3d1d4ecaa2d9414c902c7249254c6fee
Autor:
Zong Miao, Lei Xu, Wei Gu, Yimin Ren, Rong Li, Shuai Zhang, Chao Chen, Hongxiang Wang, Jing Ji, Juxiang Chen
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103220- (2024)
Temozolomide (TMZ) is a widely utilized chemotherapy treatment for patients with glioblastoma (GBM), although drug resistance constitutes a major therapeutic hurdle. Emerging evidence suggests that ferroptosis-mediated therapy could offer an appropri
Externí odkaz:
https://doaj.org/article/929b58daa077451dbffc8909fd5575f1
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-25 (2024)
Abstract Background Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), the cardiovascular autonomic center, to increase sympathe
Externí odkaz:
https://doaj.org/article/45ff23b2997a412fa54f6c771eea451b
Autor:
Yongrui Hai, Renming Fan, Ting Zhao, Ruizhuo Lin, Junyan Zhuang, Aohua Deng, Shanshui Meng, Zhuang Hou, Gaofei Wei
Publikováno v:
Pharmacological Research, Vol 202, Iss , Pp 107115- (2024)
Dihydroorotate dehydrogenase (DHODH)-mediated ferroptosis defense is a targetable vulnerability in cancer. Currently, only a few DHODH inhibitors have been utilized in clinical practice. To further enhance DHODH targeting, we introduced the mitochond
Externí odkaz:
https://doaj.org/article/0f0a8868cb46407fb20e10e039054461
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Tanzina Mollick, Suhas Darekar, Basile Dalarun, Flavia Plastino, Juan Zhang, Andres Pastor Fernández, Twana Alkasalias, Helder André, Sonia Laín
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23831- (2024)
Retinoblastoma is an eye cancer that commonly affects young children. Despite significant advances, current treatments cause side effects even when administered locally, and patients may still have to undergo enucleation. This is particularly dishear
Externí odkaz:
https://doaj.org/article/c582d86aa6a9459dbb5b0bce5058ee33