Zobrazeno 1 - 4
of 4
pro vyhledávání: '"DHO, dihydroorotate"'
Autor:
Dengke Tian, Liang Xin, Minge Wan, Xie Xiaolin, Zhang Dezhu, Wenqiang Cao, Liang Chengyuan, Liu Yuzhi, Li Han, Hong Liu, Xueqi Fu
Publikováno v:
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Graphical abstract
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
Autor:
Caterina Strambio-De-Castillia, Stuart W. Peltz, Christopher R. Trotta, Joseph M. Colacino, Elizabeth Goodwin, Liangxian Cao, Yetao Wang, Ellen L Suder, Elke Mühlberger, Sina Bavari, Jason D. Graci, Allan Jacobson, Mark Pykett, Kylie O'Keefe, Rachel A. Sattler, Ronald Kong, Ellen Welch, Jeremy Luban, Katherine Cintron-Lue, Marla Weetall, Slobodan Paessler, Veronica Soloveva, Nikolai Naryshkin
Publikováno v:
Virus Research
bioRxiv
bioRxiv
Highlights • COVID-19 is typified by SARS-CoV-2 replication and excessive inflammatory response. • PTC299 is small orally available DHODH inhibitor that blocks pyrimidine synthesis. • PTC299 is potent inhibitor of the replication of SARS-CoV-2
Autor:
Haruyoshi Yamaza, Mikako Yagi, Takeshi Uchiumi, Toshiro Saito, Kazuaki Nonaka, Dongchon Kang, Tomotake Kanki, Jing Xian Fang, Shinya Matsumoto, Shinya Takazaki, Rie Amamoto
Publikováno v:
Bioscience Reports, Vol 32, Iss 6 (2012)
Bioscience Reports
Bioscience Reports
Miller syndrome is a recessive inherited disorder characterized by postaxial acrofacial dysostosis. It is caused by dysfunction of the DHODH (dihydroorotate dehydrogenase) gene, which encodes a key enzyme in the pyrimidine de novo biosynthesis pathwa
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