Zobrazeno 1 - 10
of 136
pro vyhledávání: '"DHO, dihydroorotate"'
Autor:
Dengke Tian, Liang Xin, Minge Wan, Xie Xiaolin, Zhang Dezhu, Wenqiang Cao, Liang Chengyuan, Liu Yuzhi, Li Han, Hong Liu, Xueqi Fu
Publikováno v:
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Graphical abstract
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
Autor:
Caterina Strambio-De-Castillia, Stuart W. Peltz, Christopher R. Trotta, Joseph M. Colacino, Elizabeth Goodwin, Liangxian Cao, Yetao Wang, Ellen L Suder, Elke Mühlberger, Sina Bavari, Jason D. Graci, Allan Jacobson, Mark Pykett, Kylie O'Keefe, Rachel A. Sattler, Ronald Kong, Ellen Welch, Jeremy Luban, Katherine Cintron-Lue, Marla Weetall, Slobodan Paessler, Veronica Soloveva, Nikolai Naryshkin
Publikováno v:
Virus Research
bioRxiv
bioRxiv
Highlights • COVID-19 is typified by SARS-CoV-2 replication and excessive inflammatory response. • PTC299 is small orally available DHODH inhibitor that blocks pyrimidine synthesis. • PTC299 is potent inhibitor of the replication of SARS-CoV-2
Autor:
Haruyoshi Yamaza, Mikako Yagi, Takeshi Uchiumi, Toshiro Saito, Kazuaki Nonaka, Dongchon Kang, Tomotake Kanki, Jing Xian Fang, Shinya Matsumoto, Shinya Takazaki, Rie Amamoto
Publikováno v:
Bioscience Reports, Vol 32, Iss 6 (2012)
Bioscience Reports
Bioscience Reports
Miller syndrome is a recessive inherited disorder characterized by postaxial acrofacial dysostosis. It is caused by dysfunction of the DHODH (dihydroorotate dehydrogenase) gene, which encodes a key enzyme in the pyrimidine de novo biosynthesis pathwa
Autor:
Fan, Yipu1,2,3 (AUTHOR), Zhang, Yihan4 (AUTHOR), Qin, Dajiang1,4,5 (AUTHOR), Shu, Xiaodong2,6 (AUTHOR) shu_xiaodong@gibh.ac.cn
Publikováno v:
Cell & Bioscience. 6/5/2024, Vol. 14 Issue 1, p1-16. 16p.
Autor:
Hasan, Muhammad M.1,2 (AUTHOR), Mattice, Ethan B.1,2 (AUTHOR), Teixeira, José E.1 (AUTHOR), Jumani, Rajiv S.1,2 (AUTHOR), Stebbins, Erin E.1 (AUTHOR), Klopfer, Connor E.1 (AUTHOR), Franco, Sebastian E.1 (AUTHOR), Love, Melissa S.3 (AUTHOR), McNamara, Case W.3 (AUTHOR), Huston, Christopher D.1,2 (AUTHOR) christopher.huston@uvm.edu
Publikováno v:
PLoS Pathogens. 4/26/2024, Vol. 20 Issue 4, p1-24. 24p.
Autor:
Nozaki, Hisayoshi1 nozaki@biol.s.u-tokyo.ac.jp., Matsuzaki, Motomichi2, Misumi, Osami3,4, Kuroiwa, Haruko3,4, Higashiyama, Tetsuya1, Kuroiwa, Tsuneyoshi3
Publikováno v:
Journal of Phycology. Jun2005, Vol. 41 Issue 3, p652-657. 6p.
Akademický článek
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Autor:
Binwei Jin, Zhiming Zhang, Yang Zhang, Minjun Yang, Cheng Wang, Jiayi Xu, Yu Zhu, Yafei Mi, Jianjun Jiang, Zhenzhu Sun
Publikováno v:
Frontiers in Pharmacology; 2024, p1-19, 19p
Publikováno v:
Annual Review of Biochemistry; 8/2/2024, Vol. 93 Issue 1, p499-528, 30p
Autor:
Akberdin, Ilya R.1,2,3,4 (AUTHOR) akberdinir@gmail.com, Kozlov, Konstantin N.5 (AUTHOR), Kazantsev, Fedor V.1,2,6 (AUTHOR), Fadeev, Stanislav I.7 (AUTHOR), Likhoshvai, Vitaly A.1 (AUTHOR), Khlebodarova, Tamara M.1,6 (AUTHOR)
Publikováno v:
International Journal of Molecular Sciences. Mar2023, Vol. 24 Issue 5, p4806. 13p.