Zobrazeno 1 - 10
of 48
pro vyhledávání: '"DGR Evans"'
Background: Immune checkpoint inhibitors (ICPI) are a tumour agnostic treatment. However, trials of their use have been site specific. Here we summarise the trial data and explore the utility of programmed death-ligand 1 (PD-L1) expression as a bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec47d17bf1ff6c3ab6b067f115ea7bd
https://doi.org/10.21203/rs.3.rs-2493110/v1
https://doi.org/10.21203/rs.3.rs-2493110/v1
Autor:
Dgr Evans, Rosa Legood, Li Yang, Li Sun, Isabel dos-Santos-Silva, Shuai Li, Jack Cuzick, Shreeya Patel, John L. Hopper, Zia Sadique, Adam R. Brentnall, Stephen W. Duffy, Diana Eccles, Eja Bowles, Ranjit Manchanda, Dsm Buist
Publikováno v:
Regional plenary.
Introduction/Background Currently breast cancer (BC) patients are offered genetic-testing only if they have a ≥10% risk of being a BRCA carrier based on family history and clinical criteria. However, this approach misses a large proportion (∼50%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13e25955535f538643a134e2ed9d3f7
https://doi.org/10.1136/ijgc-2019-igcs.66
https://doi.org/10.1136/ijgc-2019-igcs.66
Autor:
Woof VG; University of Manchester, Manchester, United Kingdom., Howell A; University of Manchester, Manchester, United Kingdom.; Family History Risk and Prevention Clinic, Prevent Breast Cancer Unit, Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Fox L; Family History Risk and Prevention Clinic, Prevent Breast Cancer Unit, Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom., McWilliams L; University of Manchester, Manchester, United Kingdom., Evans DGR; University of Manchester, Manchester, United Kingdom.; Family History Risk and Prevention Clinic, Prevent Breast Cancer Unit, Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom., French DP; University of Manchester, Manchester, United Kingdom.
Publikováno v:
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 Dec 02; Vol. 33 (12), pp. 1671-1677.
Autor:
Morgan RD; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom. robert.morgan7@nhs.net.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. robert.morgan7@nhs.net.; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom. robert.morgan7@nhs.net., Wang X; Clinical Outcome and Data Unit, The Christie NHS Foundation Trust, Manchester, United Kingdom., Barnes BM; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom., Spurgeon L; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom., Carrot A; Centre pour l'lnnovation en Cancérologie de Lyon (CICLY), EA 3738, Université Claude Bernard University Lyon 1, Univ Lyon 1, Oullins-Pierre-Bénite, France., Netto D; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom., Hasan J; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom., Mitchell C; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom., Salih Z; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom., Desai S; Department of Histopathology, The Christie NHS Foundation Trust, Manchester, United Kingdom., Shaw J; Department of Histopathology, Manchester University NHS Foundation Trust, Manchester, United Kingdom.; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Winter-Roach B; Department of Gynaecological Surgery, The Christie NHS Foundation Trust, Manchester, United Kingdom., Schlecht H; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Burghel GJ; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom.; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom.; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Clamp AR; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom., Edmondson RJ; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom.; Department of Gynaecological Surgery, Manchester University NHS Foundation Trust, Manchester, United Kingdom., You B; Centre pour l'lnnovation en Cancérologie de Lyon (CICLY), EA 3738, Université Claude Bernard University Lyon 1, Univ Lyon 1, Oullins-Pierre-Bénite, France.; Service d'oncologie médicale, Institut de Cancérologie des Hospices Civils de Lyon (IC-HCL), CITOHL, EPSILYON, Centre Hospitalier Lyon-Sud, Oullins-Pierre-Bénite, France., Evans DGR; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom.; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Saint Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom.; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom., Jayson GC; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom., Taylor SS; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Manchester Academic Health Science Centre (MAHSC), Manchester, United Kingdom.
Publikováno v:
British journal of cancer [Br J Cancer] 2024 Dec; Vol. 131 (12), pp. 1919-1927. Date of Electronic Publication: 2024 Nov 16.
Autor:
Morgan RD; The Christie NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom. Electronic address: robert.morgan7@nhs.net., Burghel GJ; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Manchester, United Kingdom; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom., Flaum N; The Christie NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom., Schlecht H; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Manchester, United Kingdom., Clamp AR; The Christie NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom., Hasan J; The Christie NHS Foundation Trust, Manchester, United Kingdom., Mitchell C; The Christie NHS Foundation Trust, Manchester, United Kingdom., Salih Z; The Christie NHS Foundation Trust, Manchester, United Kingdom., Moon S; University Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom., Hogg M; Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom., Lord R; Clatterbridge Cancer Centre, Liverpool, United Kingdom., Forde C; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom., Lalloo F; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom., Woodward ER; Manchester Centre for Genomic Medicine, North West Genomic Laboratory Hub, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom., Crosbie EJ; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom., Taylor SS; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom., Jayson GC; The Christie NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, United Kingdom., Evans DGR; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom; Manchester University NHS Foundation Trust, Manchester, United Kingdom. Electronic address: gareth.d.evans@manchester.ac.uk.
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2024 Oct; Vol. 26 (10), pp. 101230. Date of Electronic Publication: 2024 Jul 31.
Autor:
Gootzen TA; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK., Kalra A; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK., Sarig K; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK., Sobočan M; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Maribor, Taborksa ul, 2000 Maribor, Slovenia., Oxley SG; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK., Dworschak N; Barts and the London School of Medicine, Queen Mary University of London, London E1 2AD, UK., Georgiannakis A; Barts and the London School of Medicine, Queen Mary University of London, London E1 2AD, UK., Glynou S; Barts and the London School of Medicine, Queen Mary University of London, London E1 2AD, UK., Taniskidi A; Barts and the London School of Medicine, Queen Mary University of London, London E1 2AD, UK., Ganesan S; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK., Ferris M; Lane End Medical Practice, London HA8 9GJ, UK., Legood R; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London WC1H 9SH, UK., Eeles R; The Institute of Cancer Research, and Royal Marsden NHS Foundation Trust, London SM2 5PT, UK., Evans DGR; Manchester Centre for Genomic Medicine, Division of Evolution, Infection and Genomic Sciences, University of Manchester, MAHSC, 6th Floor Saint Mary's Hospital, Manchester M13 9WL, UK., Fierheller CT; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK., Manchanda R; Centre for Cancer Screening, Prevention & Early Diagnosis, Wolfson Institute of Population Health, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Gynaecological Oncology, Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.; Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London WC1H 9SH, UK.; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, Faculty of Population Health Sciences, University College London, London WC1V 6LJ, UK.
Publikováno v:
Cancers [Cancers (Basel)] 2024 Jun 25; Vol. 16 (13). Date of Electronic Publication: 2024 Jun 25.
Autor:
Zhang Z; Division of Oncological Sciences, Oregon Health & Science University, Portland.; Knight Cancer Institute, Oregon Health & Science University, Portland., Ye S; Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland., Bernhardt SM; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland., Nelson HD; Kaiser Permanente Bernard D. Tyson School of Medicine, Pasadena, California., Velie EM; Zilber College of Public Health, University of Wisconsin-Milwaukee, Milwaukee.; Departments of Medicine and Pathology, Medical College of Wisconsin, Milwaukee., Borges VF; Young Women's Breast Cancer Translational Program, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora., Woodward ER; Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution Infection and Genomic Science, St Mary's Hospital, University of Manchester, Manchester, United Kingdom.; Prevent Breast Cancer Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, United Kingdom.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.; Manchester Breast Centre, University of Manchester, Manchester, United Kingdom., Evans DGR; Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution Infection and Genomic Science, St Mary's Hospital, University of Manchester, Manchester, United Kingdom.; Prevent Breast Cancer Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, United Kingdom.; Manchester Centre for Genomic Medicine, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.; Manchester Breast Centre, University of Manchester, Manchester, United Kingdom., Schedin PJ; Knight Cancer Institute, Oregon Health & Science University, Portland.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland.
Publikováno v:
JAMA network open [JAMA Netw Open] 2024 Apr 01; Vol. 7 (4), pp. e247421. Date of Electronic Publication: 2024 Apr 01.
Autor:
Morgan RD; Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester M13 9PL, UK., Burghel GJ; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester M13 9PL, UK., Schlecht H; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK., Clamp AR; Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester M13 9PL, UK., Hasan J; Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK., Mitchell CL; Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK., Salih Z; Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK., Shaw J; Department of Gynaecological Pathology, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK., Desai S; Department of Pathology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK., Jayson GC; Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester M13 9PL, UK., Woodward ER; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester M13 9PL, UK.; Department of Clinical Genetics, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK., Evans DGR; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.; Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester M13 9PL, UK.; Department of Clinical Genetics, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK.
Publikováno v:
Cancers [Cancers (Basel)] 2023 Dec 29; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 29.
Autor:
Evans DGR; Manchester for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, UK. gareth.evans@mft.nhs.uk.; Division of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. gareth.evans@mft.nhs.uk.; Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, Manchester, UK. gareth.evans@mft.nhs.uk.; Manchester Breast Centre, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK. gareth.evans@mft.nhs.uk., Howell A; Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, Manchester, UK.; Manchester Breast Centre, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK.; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Howell Sacha J; Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester Universities Foundation Trust, Wythenshawe, Manchester, UK.; Manchester Breast Centre, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK.; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Publikováno v:
European journal of human genetics : EJHG [Eur J Hum Genet] 2023 Nov; Vol. 31 (11), pp. 1207-1208. Date of Electronic Publication: 2023 Aug 17.
Autor:
Morgan RD; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK robert.morgan7@nhs.net., Burghel GJ; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK., Flaum N; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK.; Division of Evolution, Infection and Genomics, University of Manchester, Manchester, UK., Bulman M; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK., Smith P; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK., Clamp AR; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.; Division of Cancer Sciences, University of Manchester, Manchester, UK., Hasan J; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK., Mitchell C; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK., Salih Z; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK., Woodward ER; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK.; Department of Clinical Genetics, Manchester University NHS Foundation Trust, Manchester, UK., Lalloo F; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK.; Department of Clinical Genetics, Manchester University NHS Foundation Trust, Manchester, UK., Shaw J; Department of Histopathology, Manchester University NHS Foundation Trust, Manchester, UK., Desai S; Department of Histopathology, The Christie NHS Foundation Trust, Manchester, UK., Crosbie EJ; Division of Cancer Sciences, University of Manchester, Manchester, UK.; Department of Gynaecological Surgery, Manchester University NHS Foundation Trust, Manchester, UK., Edmondson RJ; Division of Cancer Sciences, University of Manchester, Manchester, UK.; Department of Gynaecological Surgery, Manchester University NHS Foundation Trust, Manchester, UK., Schlecht H; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK., Wallace AJ; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK., Jayson GC; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.; Division of Cancer Sciences, University of Manchester, Manchester, UK., Evans DGR; North West Genomic Laboratory Hub, Manchester University NHS Foundation Trust, Manchester, UK.; Division of Evolution, Infection and Genomics, University of Manchester, Manchester, UK.; Department of Clinical Genetics, Manchester University NHS Foundation Trust, Manchester, UK.
Publikováno v:
Journal of clinical pathology [J Clin Pathol] 2023 Oct; Vol. 76 (10), pp. 684-689. Date of Electronic Publication: 2022 Jun 23.