Zobrazeno 1 - 10
of 200
pro vyhledávání: '"DGLA"'
Autor:
Marija Knez, Erick Boy
Publikováno v:
Frontiers in Nutrition, Vol 9 (2023)
The role of Zn in human health was discovered 60 years ago, and despite remarkable research efforts, a sufficiently sensitive and specific biomarker of Zn status is still lacking. Plasma/serum Zn, currently the best available and most accepted popula
Externí odkaz:
https://doaj.org/article/2f6cdf5d03cf493b83307ca409f2295f
Publikováno v:
Cells, Vol 12, Iss 5, p 804 (2023)
Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has emerged as a key driver of oxidative damage to cellular
Externí odkaz:
https://doaj.org/article/b6003d5754664e4b971c49390fb9dfc6
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 222-235 (2020)
Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydr
Externí odkaz:
https://doaj.org/article/a6e26193aa3640e99d722ec2e98e7807
Autor:
Anne-Mari Mustonen, Petteri Nieminen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2116 (2023)
Dihomo-γ-linolenic acid (DGLA) has emerged as a significant molecule differentiating healthy and inflamed tissues. Its position at a pivotal point of metabolic pathways leading to anti-inflammatory derivatives or via arachidonic acid (ARA) to pro-in
Externí odkaz:
https://doaj.org/article/f3c186e7675749bf805c2d85349e1b86
Autor:
Marija Takic, Milica Zekovic, Brankica Terzic, Aleksandar Stojsavljevic, Mirjana Mijuskovic, Slavica Radjen, Danijela Ristic-Medic
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn
Externí odkaz:
https://doaj.org/article/294be13e987049519d9df547b7baff1e
Autor:
Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Li Liang, Victoriano Garre, Yuanda Song
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-8 (2019)
Abstract Background Dihomo-gamma linolenic acid (DGLA, 20:3, n-6) is the elongated product of Gamma linolenic acid (GLA, 18:3, n-6) catalyzed by the enzyme delta-6 elongase (D6E) or gamma linolenic acid elongase (GLELO). Construction of engineered ol
Externí odkaz:
https://doaj.org/article/9ee821b92451496690ce6a10371f45c0
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the production of the ant
Externí odkaz:
https://doaj.org/article/febdfc602dda4ffcacfd0bd798f7f3de
Autor:
Dennis Winston T. Nilsen, Peder Langeland Myhre, Are Kalstad, Erik Berg Schmidt, Harald Arnesen, Ingebjørg Seljeflot
Publikováno v:
Nutrients, Vol 13, Iss 10, p 3475 (2021)
Dihomo-gamma-linolenic acid (DGLA) is an n-6 polyunsaturated fatty acid (PUFA) derived from linoleic acid (LA). The LA:DGLA ratio reflects conversion from LA to DGLA. Low levels of DGLA in serum have been related to poor outcome in myocardial infarct
Externí odkaz:
https://doaj.org/article/bb05fd6d67af4ecb8bf9efaf51028bde
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Cyclooxygenase-2 (COX-2), the inducible COX form, is a bi-functional membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty acid) to form 2-series of prostaglandins known to be involved in cancer
Externí odkaz:
https://doaj.org/article/c2c5ce7b03bc458db5b1ceac22f35d82
Publikováno v:
Nutrients, Vol 13, Iss 10, p 3399 (2021)
Zinc (Zn) deficiency is estimated to affect over one billion (17%) of the world’s population. Zn plays a key role in various cellular processes such as differentiation, apoptosis, and proliferation, and is used for vital biochemical and structural
Externí odkaz:
https://doaj.org/article/2501d1fe3c46486fb18e5cef8ddd1101