Výsledky vyhledávání

Akademický článek

Society of Biomolecular Imaging and Informatics High-Content Screening/High-Content Analysis Emerging Technologies in Biological Models, When and Why?

Autor: Hoffman AF; 1 GlaxoSmithKline , Collegeville, Pennsylvania., Nolan J; 2 The Scintillon Institute , San Diego, California., Gebhard DF; 3 Pfizer, Inc. , Groton, Connecticut., Nickischer D; 3 Pfizer, Inc. , Groton, Connecticut., Omta W; 4 Core Life Analytics B.V. , Utrecht, The Netherlands ., Cooper S; 5 Imperial College London, Institute of Cancer Research , London, United Kingdom ., Presnell S; 6 Organovo, Inc. & Samsara Sciences, Inc. , San Diego, California., Wardwell-Swanson J; 7 InSphero, Inc. , Brunswick, Maine., Fennell M; 8 Memorial Sloan Kettering Cancer Center , New York, New York.

Publikováno v: Assay and drug development technologies [Assay Drug Dev Technol] 2018 Jan; Vol. 16 (1), pp. 1-6.

Zobrazit plný text záznamu

Akademický článek

Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621.

Autor: Michaud NR; Pfizer Global Research and Development, Groton, CT, USA. neil.michaud@astrazeneca.com, Jani JP, Hillerman S, Tsaparikos KE, Barbacci-Tobin EG, Knauth E, Putz H Jr, Campbell M, Karam GA, Chrunyk B, Gebhard DF, Green LL, Xu JJ, Dunn MC, Coskran TM, Lapointe JM, Cohen BD, Coleman KG, Bedian V, Vincent P, Kajiji S, Steyn SJ, Borzillo GV, Los G

Publikováno v: MAbs [MAbs] 2012 Nov-Dec; Vol. 4 (6), pp. 710-23. Date of Electronic Publication: 2012 Sep 24.

Zobrazit plný text záznamu

Akademický článek

Antitumor effect of vascular endothelial growth factor inhibitor sunitinib in preclinical models of hepatocellular carcinoma.

Autor: Bagi CM; Worldwide Comparative Medicine, GS&T, Groton, Connecticut, USA. cedo.bagi@pfizer.com, Gebhard DF, Andresen CJ

Publikováno v: European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2012 May; Vol. 24 (5), pp. 563-74.

Zobrazit plný text záznamu

Akademický článek

Development of a new permeability assay using low-efflux MDCKII cells.

Autor: Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA. li.di@pfizer.com, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ 3rd, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, Kempshall S, Fenner K, El-Kattan AF, Liston TE, Troutman MD

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2011 Nov; Vol. 100 (11), pp. 4974-85. Date of Electronic Publication: 2011 Jul 15.

Zobrazit plný text záznamu

Akademický článek

High-throughput assays for assessing mitochondrial dysfunction caused by compounds that impair mtDNA-encoded protein levels in eukaryotic cells.

Autor: Nadanaciva S; Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut, USA., Murray J, Wilson C, Gebhard DF, Will Y

Publikováno v: Current protocols in toxicology [Curr Protoc Toxicol] 2011 May; Vol. Chapter 3, pp. Unit3.11.

Zobrazit plný text záznamu

Akademický článek

A high content screening assay for identifying lysosomotropic compounds.

Autor: Nadanaciva S; Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer Inc., Groton, CT 06340, USA. sashi.nadanaciva@pfizer.com, Lu S, Gebhard DF, Jessen BA, Pennie WD, Will Y

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2011 Apr; Vol. 25 (3), pp. 715-23. Date of Electronic Publication: 2010 Dec 22.

Zobrazit plný text záznamu

Akademický článek

High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells.

Autor: Nadanaciva S; Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer Inc., Groton, CT 06340, USA. sashi.nadanaciva@pfizer.com, Dillman K, Gebhard DF, Shrikhande A, Will Y

Publikováno v: Journal of biomolecular screening [J Biomol Screen] 2010 Sep; Vol. 15 (8), pp. 937-48. Date of Electronic Publication: 2010 Jul 12.

Zobrazit plný text záznamu

Akademický článek

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.

Autor: Buckbinder L; Pfizer Global Research and Development, Groton, CT 06340, USA. leonard.buckbinder@pfizer.com, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA 3rd, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2007 Jun 19; Vol. 104 (25), pp. 10619-24. Date of Electronic Publication: 2007 May 30.

Zobrazit plný text záznamu

Akademický článek

Immunophenotypic characterization of human fetal liver hematopoietic stem cells during the midtrimester of gestation.

Autor: Gilles JM; Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Divon MY, Bentolila E, Rotenberg OD, Gebhard DF, Rashbaum WK, Lyman WD

Publikováno v: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1997 Sep; Vol. 177 (3), pp. 619-25.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání