Zobrazeno 1 - 10
of 219
pro vyhledávání: '"DEVRIES JE"'
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(12)
Differential expression of cytokine receptors accounts for an important regulatory mechanism in differentiation of Th1/Th2 subsets. Here, we report that human Th0 and Th2 clones constitutively express transcripts for the IFN-gamma R beta-chain, where
The effects of a novel cytokine FLK2/FLT3 ligand (FL) on human fetal bone marrow-derived CD34(+)CD19(+) pro-B cells were analyzed in a stromal-cell-independent, serum-deprived culture system. FL, like interleukin-3 (IL-3), synergized with IL-7 in pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::fda4ff4da79572c10a33322f3d0499f0
Autor:
BACCHETTA R, PARKMAN R, MCMAHON M, WEINBERG K, BIGLER M, DEVRIES JE, RONCAROLO , MARIA GRAZIA
We have investigated the mechanism of tolerance in a patient with severe combined immunodeficiency (SCID) transplanted with HLA-haploidentical, T cell-depleted bone marrow cells obtained from the mother. At 4 years after transplantation, T cells, nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::2a3ccfa07abb9b6410231313238c2012
Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::9b1d8aa40064b04dee797fafbed0969f
Autor:
GASCAN H, AVERSA GG, GAUCHAT JF, VANVLASSELAER P, YSSEL H, KEHRY M, SPITS H, DEVRIES JE, RONCAROLO , MARIA GRAZIA
In the present study it is demonstrated that human B cells can be induced to switch to IgE production following a contact-mediated signal provided by activated T cell receptor (TcR) gamma-delta+, CD4+ and TcR alpha-beta+, CD4+ T cell clones and inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::d6403a7d04bb3a40e96663de473ee651
Murine IL-10 has been reported originally to be produced by the Th2 subset of CD4+ T cell clones. In this study, we demonstrate that human IL-10 is produced by Th0, Th1-, and Th2-like CD4+ T cell clones after both Ag-specific and polyclonal activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::e19f69c3ce5226b2706a02d4b2bc894c
We studied a severe combined immunodeficiency (SCID) patient who received transplantations with completely HLA-mismatched fetal liver and thymus from two different donors. The patient is now 14 years old, healthy and shows normal immunoresponses to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::2c9cf6d6c6326dff80da489aa9fbef71
NK cell clones obtained from three different donors were tested for their ability to present soluble proteins to Ag-specific T cell clones. All NK clones were CD2+CD3-CD56+, whereas the expression of CD16 varied from clone to clone. The NK cell clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::7bee3030f0087145f207dc32ede6b2ac
Interleukin-4 (IL-4) has been shown to induce immunoglobulin E (IgE) synthesis by human peripheral blood lymphocytes (PBL). Here we show that highly purified B-cells (> 99.5%) failed to produce IgE in the presence of IL-4 but IgE synthesis was restor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::dbd0d745c7eef5599a5ec0c3cf9bebbd
Autor:
MALEFYT RD, HAANEN J, SPITS H, TEVELDE A, FIGDOR C, JOHNSON K, KASTELEIN R, YSSEL H, DEVRIES JE, RONCAROLO , MARIA GRAZIA
Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation of human T cells and CD4+ T cells clones when monocytes were used as antigen-presenting cells. In contrast, IL-10 and v-IL-10 did not affect the prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10495::f7063369ba6a8c447f24bed4a6cc54d9