Zobrazeno 1 - 10
of 2 102
pro vyhledávání: '"DESMOND M"'
Autor:
Geoffrey Howe, Mehtap Bal, Matt Wasmuth, Giulia Massaro, Ahad A. Rahim, Sadfer Ali, Milena Rivera, Desmond M. Schofield, Aminat Omotosho, John Ward, Eli Keshavarz-Moore, Chris Mason, Darren N. Nesbeth
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101317- (2024)
We sought to engineer mammalian cells to secrete nuclease activity as a step toward removing the need to purchase commercial nucleases as process additions in bioprocessing of AAV5 and AAV9 as gene therapy vectors. Engineering HeLa cells with a serra
Externí odkaz:
https://doaj.org/article/899c50db9a0c443f9c3134dcde1e9048
Publikováno v:
Hemato, Vol 4, Iss 4, Pp 301-310 (2023)
The blood coagulation response to decompression stress in humans has yet to be fully investigated. Here we utilised calibrated automated thrombogram (CAT) on samples from healthy volunteers exposed to decompression stress to investigate real-time thr
Externí odkaz:
https://doaj.org/article/4bd66d9654ea4a68a92eaf78a55c42e8
Autor:
Desmond M Murphy, B J Plant, Joseph A Eustace, Parniya Arooj, David V Morrissy, Yvonne McCarthy, Tamara Vagg, Mairead McCarthy, Claire Fleming, Mary Daly
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Previous studies showed that the combination of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) corrector and potentiator, lumacaftor–ivacaftor (LUMA–IVA) provides meaningful clinical benefits in patients with cystic fibrosi
Externí odkaz:
https://doaj.org/article/49db3130031441878d029412e4fb451a
Autor:
Hisham Ibrahim, Hammad Danish, David Morrissey, Kevin F. Deasy, Mairead McCarthy, James Dorgan, Claire Fleming, Ciara Howlett, Sarah Twohig, Tamara Vagg, Desmond M. Murphy, Michael Maher, Barry J. Plant
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The prevalence of mental health disorders is high among people with Cystic Fibrosis. The psychological symptoms in CF are associated with poor adherence, worse treatment outcomes, and greater health utilization/cost. Mental health and neurocognitive
Externí odkaz:
https://doaj.org/article/7bb23dea61d344e0b8319f6455ac143b
Autor:
Laura J. Walsh, Deborah Casey, Punitha Vairamani, Fiona Arnott, Barry J. Plant, Desmond M. Murphy
Publikováno v:
Frontiers in Allergy, Vol 3 (2023)
IntroductionApproximately 3%–10% of asthma patients will remain uncontrolled despite maximum, optimal conventional therapy. Treatment of severe refractory asthma often involves the use of targeted biological therapy. Randomised controlled trials ha
Externí odkaz:
https://doaj.org/article/5a30f0b80bdb47e7872ebaaa797dc871
Autor:
Robert E. Merritt, Peter J. Kneuertz, Mahmoud Abdel-Rasoul, Desmond M. D’Souza, Kyle A. Perry
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Locally advanced esophageal carcinoma is typically treated with neoadjuvant chemoradiation and esophagectomy (trimodality therapy). We compared the long-term oncologic outcomes of minimally invasive Ivor Lewis esophagectomy (M-ILE
Externí odkaz:
https://doaj.org/article/d63a27196a9e477abc7e23fa7def94d8
Publikováno v:
Respirology Case Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract A well‐functioning 68 year old gentleman presented to our hospital with a macular rash 2 weeks after starting a course of Ciprofloxacin. There was rapid progression of skin involvement including the mucosa, complicated by pancytopaenia. To
Externí odkaz:
https://doaj.org/article/be1faa255d8345a1a99b2438219942b1
Autor:
Cathal Walsh, Michael Harrison, Richard W Costello, Roisin Adams, Desmond M Murphy, Caroline O'Leary, Christopher Schultz, Deborah Casey, Stephen Lane, Shane Doyle, Fionnuala King
Publikováno v:
BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)
Introduction Interleukin 5 (IL-5) inhibitors are an important therapeutic advance in the management of severe, refractory, eosinophilic asthma. However, their utilisation should be targeted to maximise their benefits. This study used multisite, centr
Externí odkaz:
https://doaj.org/article/f95968b6c0f14940885f3c67b2e591a1
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/6801d5800058415da6af4843de1b3157
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background The published rates of morbidity and mortality remain relatively high for patients who undergo laparoscopic and thoracoscopic Ivor Lewis esophagectomy. We report the postoperative and oncologic outcomes of a large cohort of patien
Externí odkaz:
https://doaj.org/article/3f0c780bf90943839026fe2fd57a987b