Zobrazeno 1 - 10
of 113
pro vyhledávání: '"DENNIS R. KOOP"'
Autor:
Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly, Stefan H. I. Kappe, Brandon K. Wilder, Michael K. Riscoe
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Abstract Background The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynami
Externí odkaz:
https://doaj.org/article/630a94e7fc5a4c469f0ed0eacdad2650
Autor:
Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare
PDF file - 1469K, Different ABL TKIs demonstrate potency differences in relative cellular and biochemical target inhibition (S1); Incomplete restoration of BCR-ABL signaling activity following washout of dasatinib or ponatinib tracks with intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bb2f349dbdbd12daa46b5865710272
https://doi.org/10.1158/0008-5472.22396247
https://doi.org/10.1158/0008-5472.22396247
Autor:
Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare
PDF file - 337K, Summary of mean fluorescence intensity values for levels of CrkL and STAT5 phosphorylation in K562 cells following acute ABL TKI exposure followed by standard and expanded washout (S1); Kinase:inhibitor dissociation off-rates for ABL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464ff7a97c638799f3fd2f9fd2378704
https://doi.org/10.1158/0008-5472.22396238.v1
https://doi.org/10.1158/0008-5472.22396238.v1
Autor:
Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare
PDF file - 45K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2e7b60dba00e64f41fe83e32b81c9f
https://doi.org/10.1158/0008-5472.22396250.v1
https://doi.org/10.1158/0008-5472.22396250.v1
Autor:
Robert G. Hendrickson, Tamara Grigsby, Katharine E. Zuckerman, Michael J. Moss, Steven C. Kazmierczak, Ittai Bushlin, Dennis R. Koop
Publikováno v:
Pediatric Research. 90:861-868
Background Information on cannabinoids in breast milk and maternal cannabis use is limited. We quantified cannabinoids in plasma and breast milk of breastfeeding mothers and assessed cannabis use patterns. Methods This is a prospective study at a uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae5da2a145a6ec5510aef282a82a4d15
https://doi.org/10.1038/s41390-020-01332-2
https://doi.org/10.1038/s41390-020-01332-2
Autor:
Michael K. Riscoe, Yuexin Li, Richard J. Sciotti, Brian Vesely, Aaron Nilsen, Michael W. Mather, Dennis R. Koop, Akhil B. Vaidya, Rolf W. Winter, Martin J. Smilkstein, Qigui Li, Mara Kreishman-Deitrick, Diana Caridha, Lisa Frueh, Robert F. Campbell, Sovitj Pou, Lisa H. Xie, April M. Pershing, Isaac P. Forquer, Jane X. Kelly
Publikováno v:
ACS Infectious Diseases. 3:728-735
ELQ-300 is a preclinical antimalarial drug candidate that is active against liver, blood, and transmission stages of Plasmodium falciparum. While ELQ-300 is highly effective when administered in a low multi-dose regimen, poor aqueous solubility and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249b65dc64b941bff90c86f25bc6788b
https://doi.org/10.1021/acsinfecdis.7b00062
https://doi.org/10.1021/acsinfecdis.7b00062
Autor:
Aaron Nilsen, Thomas Martinson, Alina Krollenbrock, Lisa Frueh, Lisa Bleyle, Rozalia Dodean, Samantha Whiteside, Igor Bruzual, David J. Hinrichs, Dennis R. Koop, Stefan H. I. Kappe, Sovitj Pou, Michael K. Riscoe, Jane Xu Kelly, Martin J. Smilkstein, Myrna Y. Munar, Rolf W. Winter, Yuexin Li, Brandon K. Wilder
Publikováno v:
Malaria Journal
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
BackgroundThe potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynamic and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e9df3dea5dabbdc535615107019ec2
Autor:
Jessica L. Martin, Nicola S. Carter, Audrey L. Fulwiler, Buddy Ullman, Maria B. Cassera, Dennis R. Koop, Jan M. Boitz, Phillip A. Yates
Publikováno v:
Molecular Microbiology. 101:299-313
Purine salvage by Leishmania is an obligatory nutritional process that impacts both cell viability and growth. Previously, we have demonstrated that the removal of purines in culture provokes significant metabolic changes that enable Leishmania to su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aadb00baf7f7188b5f9aed0d2bfdf4d
https://doi.org/10.1111/mmi.13390
https://doi.org/10.1111/mmi.13390
Autor:
Jeffrey Kaye, Hiroko H. Dodge, Lisa C. Silbert, Dennis R. Koop, Joseph F. Quinn, Lynne Shinto, Kirsten Hagen, David Lahna
Publikováno v:
Alzheimer's & Dementia. 15:P580-P581
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac171748987f864566028a9c08bc4da
https://doi.org/10.1016/j.jalz.2019.06.1247
https://doi.org/10.1016/j.jalz.2019.06.1247
Autor:
Phoebe Lin, Patrick Stauffer, James T. Rosenbaum, Dennis R. Koop, Sean Davin, Mark Asquith, Joe Ensign-Lewis, Claire Michell, Jason M. Kinchen, Cathleen Janowitz
Objective HLA-B27 associated spondyloarthropathies are associated with an altered intestinal microbiota and bowel inflammation. Therefore, we sought to identify B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2m rat and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516941527f6c0be000847339feb49beb
https://europepmc.org/articles/PMC5623151/
https://europepmc.org/articles/PMC5623151/