Výsledky vyhledávání - "DENNIS J. O'KANE"

The Mechanism of Bacterial Bioluminescence

Autor: Franz Müller, Dennis J. O'Kane, Jacques Vervoort, John Lee, I. B. C. Matheson, Antonie J. W. G. Visser

Publikováno v: Chemistry and Biochemistry of Flavoenzymes ISBN: 9781351070584
Chemistry and Biochemistry of Flavoenzymes. CRC Press
Chemistry and Biochemistry of Flavoenzymes

Bioluminescence is a chemiluminescence in which one of the participants is a protein and where the light emission serves a functional purpose for the organism in which the protein is found. Bioluminescence with bacterial luciferase, henceforth just r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d93d0720c553a31371aff5a812739b
https://doi.org/10.1201/9781351070584-6

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CEA, AFP and CA 19-9 analysis in peritoneal fluid to differentiate causes of ascites formation

Autor: Nicole V. Tolan, Dennis J. O'Kane, Karl A. Ness, Alicia Algeciras-Schimnich, Erin J. Kaleta

Publikováno v: Clinical Biochemistry. 46:814-818

Objectives Tumor marker analysis in ascites has been proposed as a measure to aid in the diagnosis of malignancy. The objectives of this study were to establish tumor marker cut-offs and determine the diagnostic performance of measuring CEA, CA 19-9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d563ba9453aecd0bde451a5e2bba821
https://doi.org/10.1016/j.clinbiochem.2013.02.010

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CYP2C19 variation and citalopram response

Autor: Dennis J. O'Kane, Maureen S. Drews, David A. Mrazek, Richard M. Weinshilboum, Karen Snyder, Julie M. Cunningham, Joanna M. Biernacka, A. J. Rush, Susanna R. Stevens, John L. Black

Publikováno v: Pharmacogenetics and Genomics. 21:1-9

Objective Variations in cytochrome P450 (CYP) genes have been shown to be associated with both accelerated and delayed pharmacokinetic clearance of many psychotropic medications. Citalopram is metabolized by three CYP enzymes. CYP2C19 and CYP3A4 play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4723912f8bdc51794e83eb301f82eff
https://doi.org/10.1097/fpc.0b013e328340bc5a

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Diagnostic Performance of Cyst Fluid Carcinoembryonic Antigen and Amylase in Histologically Confirmed Pancreatic Cysts

Autor: Dennis J. O'Kane, Mario Palaez-Luna, Thomas C. Smyrk, Walter G. Park, Jonathan E. Clain, Michael J. Levy, Mark Topazian, Suresh T. Chari, Bret T. Petersen, Randall K. Pearson, Santhi Swaroop Vege, Ranjan Mascarenhas

Publikováno v: Pancreas. 40:42-45

The objective of this study was to evaluate and validate cyst fluid carcinoembyronic antigen (CEA) and amylase in differentiating (1) nonmucinous from mucinous pancreatic cystic lesions (PCLs), (2) benign mucinous from malignant mucinous PCLs, and (3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c8a27f863bd70096ac6202827715e7
https://doi.org/10.1097/mpa.0b013e3181f69f36

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Alternative method of allelic discrimination

Autor: Dennis J. O'Kane, John L. Black, Rajeswari Avula

Publikováno v: BioTechniques. 57:88-90

5′ nuclease assays for allelic discrimination use both a wild-type and a mutant probe. Here we present a new method for genotyping by 5′ nuclease assays that dispenses with the mutant probe, using the wild-type probe together with a probe for a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad44eb5adc5f90e53066e253716c9a8
https://doi.org/10.2144/000114199

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Warfarin Genotyping Reduces Hospitalization Rates

Autor: Brian F. Gage, Robert R. Verbrugge, J. Russell Teagarden, Thomas P. Moyer, Robert S. Epstein, Ronald E. Aubert, Fang Xia, Dennis J. O'Kane

Publikováno v: Journal of the American College of Cardiology. 55(25):2804-2812

Objectives: This study was designed to determine whether genotype testing for patients initiating warfarin treatment will reduce the incidence of hospitalizations, including those due to bleeding o...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce746d0f6464b01ad67e8ba5633a636

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CYP2D6: novel genomic structures and alleles

Autor: Whitney Erin Kramer, J. L. Black, David A. Mrazek, Brian A. Dukek, Dennis J. O'Kane, Jamie K. Bruflat, Pamela K. Fisher, Denise L. Walker

Publikováno v: Pharmacogenetics and Genomics. 19:813-822

CYP2D6 is a polymorphic gene. It has been observed to be deleted, to be duplicated and to undergo recombination events involving the CYP2D7 pseudogene and surrounding sequences. The objective of this study was to discover the genomic structure of CYP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caf6fc07e9cb930fd6cfff4182090bc
https://doi.org/10.1097/fpc.0b013e3283317b95

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Pharmacogenetics of Solid Tumors: Directed Therapy in Breast, Lung, and Colorectal Cancer

Autor: Christine L.H. Snozek, Dennis J. O'Kane, Alicia Algeciras-Schimnich

Publikováno v: The Journal of Molecular Diagnostics. 11:381-389

Genetic variability in drug-metabolizing enzymes and signaling pathways affects chemotherapy-related toxicity and treatment outcome in cancer. In breast and colorectal cancer, polymorphisms in metabolic enzymes involved in tamoxifen and irinotecan th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df6fdfa0621fd5c720a6319b36ba34a9
https://doi.org/10.2353/jmoldx.2009.090003

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SLC6A4 variation and citalopram response

Autor: Eric D. Wieben, David A. Mrazek, Richard M. Weinshilboum, Maureen S. Drews, A.J. Rush, Julie M. Cunningham, John L. Black, Joanna M. Biernacka, Dennis J. O'Kane, V.L. Courson, Daniel J. Schaid, Karen Snyder

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :341-351

The influence of genetic variations in SLC6A4 (serotonin transporter gene) on citalopram treatment of depression using the Sequenced Treatment to Relieve Depression (STAR*D) sample was assessed. Of primary interest were three previously studied polym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9983938dde2535b204245ba9461c841
https://doi.org/10.1002/ajmg.b.30816

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Pharmacogenomics of Tamoxifen and Irinotecan Therapies

Autor: Dennis J. O'Kane, Alicia Algeciras-Schimnich, Christine L.H. Snozek

Publikováno v: Clinics in Laboratory Medicine. 28:553-567

Genetic variability in drugmetabolizing enzymes affects the toxicity and efficacy of many compounds, including the chemotherapeutic agents irinotecan and tamoxifen. The correlation of clinical response to polymorphisms in enzymes associated with meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ade8e25e89028d7e38b509e6a9c6586
https://doi.org/10.1016/j.cll.2008.05.004

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