Zobrazeno 1 - 10
of 342
pro vyhledávání: '"DENISA D WAGNER"'
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251726 (2021)
Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline. Neutrophil extracellular trap (NET) formation is the most dramatic manifest
Externí odkaz:
https://doaj.org/article/10b48c4213034cfe8a35d083d9e0bafc
Autor:
Melanie Demers, Georgette L Suidan, Nick Andrews, Kimberly Martinod, Jessica E Cabral, Denisa D Wagner
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207241 (2018)
Prevalence of depression is higher in patients with cancer than in the general population. Sustained systemic inflammation has been associated with depressive behavior and it has been reported that depressed patients commonly display alterations in t
Externí odkaz:
https://doaj.org/article/8832425d204843aba283233322607657
Autor:
Hideki Hayashi, Deya Cherpokova, Kimberly Martinod, Thilo Witsch, Siu Ling Wong, Maureen Gallant, Stephen M Cifuni, Leonard P Guarente, Denisa D Wagner
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188341 (2017)
Inflammation is a common denominator in chronic diseases of aging. Yet, how inflammation fuels these diseases remains unknown. Neutrophils are the primary leukocytes involved in the early phase of innate immunity and inflammation. As part of their an
Externí odkaz:
https://doaj.org/article/b3dadcf09d9243c48abef0bcbf1dc29f
Autor:
Pierre-André Jarrot, Jiyoun Kim, William Chan, Lukas Heger, Nicolas Schommer, Pierre Cunin, Camila M. S. Silva, Stéphane Robert, Peter A. Nigrovic, Bruce Ewenstein, Denisa D. Wagner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesDiffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus and small vessel vasculitis. We previously showed that neutrophil extracellular traps (NETs) were associated with the pathogenesis of prist
Externí odkaz:
https://doaj.org/article/7d9ac393d7b54ccfb24813f7d1ad8758
Autor:
Lukas A. Heger, Nicolas Schommer, Stijn Van Bruggen, Casey E. Sheehy, William Chan, Denisa D. Wagner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract NLRP3 inflammasome has been implicated in neutrophil polarization and extrusion of neutrophil extracellular traps (NETs) in vitro and facilitates secretion of Il1-beta (IL-1β). Permanent ligation of the left anterior descending artery was u
Externí odkaz:
https://doaj.org/article/bb375915f1774da892a3bf089acbc5f9
Autor:
Georgette L Suidan, Daniel Duerschmied, Gregory M Dillon, Veronique Vanderhorst, Thomas G Hampton, Siu Ling Wong, Jaymie R Voorhees, Denisa D Wagner
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59032 (2013)
The role of peripheral serotonin in nervous system development is poorly understood. Tryptophan hydroxylase-1 (TPH1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal gland and is the rate-limit
Externí odkaz:
https://doaj.org/article/824dc76da543400cb374e94be31e4bee
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13433 (2010)
ADAM17/TACE activity is important during embryonic development. We wished to investigate possible roles of this metalloprotease, focusing on vascular development.Mice mutant in the enzymatic activity of ADAM17 were examined at various stages of embry
Externí odkaz:
https://doaj.org/article/348a410ea08d4628bef4d1664fdc4140
Autor:
Chandru Gajendran, Shoichi Fukui, Naveen M. Sadhu, Mohammed Zainuddin, Sridharan Rajagopal, Ramachandraiah Gosu, Sarah Gutch, Saeko Fukui, Casey E. Sheehy, Long Chu, Santosh Vishwakarma, D. A. Jeyaraj, Gurulingappa Hallur, Denisa D. Wagner, Dhanalakshmi Sivanandhan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies in mice. Further, studies with PAD4 – d
Externí odkaz:
https://doaj.org/article/6dafa58388074e5abe4049b5154399a4
Autor:
Karen Aymonnier, Julie Ng, Laura E. Fredenburgh, Katherin Zambrano-Vera, Patrick Münzer, Sarah Gutch, Shoichi Fukui, Michael Desjardins, Meera Subramaniam, Rebecca M Baron, Benjamin A. Raby, Mark A. Perrella, James A. Lederer, Denisa D. Wagner
Publikováno v:
Blood Advances
Neutrophils with intact multilobulated nuclei show ASC speck formation and high histone H3 citrullination in patients with severe COVID-19. In murine neutrophils, ASC speck forms transiently at the microtubule organizing center, before nuclear roundi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3d348f6b42fd70ee7088e2de7508d8
https://doi.org/10.1182/bloodadvances.2021005949
https://doi.org/10.1182/bloodadvances.2021005949
Supplementary Figure 1 from Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee9ffff65625f5407d5629451b0d7ae
https://doi.org/10.1158/0008-5472.22389101.v1
https://doi.org/10.1158/0008-5472.22389101.v1
