Using Artificial Intelligence-based Methods to Address the Placebo Response in Clinical Trials.

Autor: Smith EA; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Horan WP; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Demolle D; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Schueler P; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Fu DJ; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Anderson AE; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Geraci J; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Butlen-Ducuing F; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Link J; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Khin NA; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Morlock R; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey)., Alphs LD; Drs. Smith and Demolle are with Cognivia in Mont St. Guibert, Belgium.; Dr. Horan is with VeraSci in Durham, North Carolina.; Drs. Horan and Anderson are with the University of California at Los Angeles in Los Angeles, California.; Dr. Schueler is with ICON Clinical Research in Langen, Germany.; Dr. Fu is with Janssen Reasearch and Development, LLC, in Titusville, New Jersey.; Dr. Geraci is with Nurosene Health, Inc. in Toronto, Ontario; Queen's University in Kingston, Ontario; and the Center for Biotechnology and Genomics Medicine, Medical College of Georgia, in Augusta, Georgia.; Dr. Butlen-Ducuing is with European Medicines Agency in Amsterdam, Netherlands.; Ms. Link is with Boehringer Ingelheim Pharma GmbH and Company KG in Baden Württenberg, Germany.; Dr. Khin is with Neurocrine Biosciences, Inc. in San Diego, California.; Dr. Morlock is with YourCareChoice in Ann Arbor, Michigan.; Dr. Alphs is with Denovo Biopharma, LLC in San Diego, California (at the time of writing, he was with Newron Pharmaceuticals in Morriston, New Jersey).

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