Zobrazeno 1 - 10
of 11
pro vyhledávání: '"DELWIN L. BOKELMAN"'
Autor:
Delwin L. Bokelman, Keith A. Soper, Matthew J. Van Zwieten, Srinivasa Prahalada, Phillip R. Hertzog, Kevin P. Keenan, Lea R. Gordon, Chennekatu P. Peter
Publikováno v:
Urology. 43:680-685
Objective. To determine any potential direct and/or indirect effects of elevated intraprostatic T levels on the prostates of rats chronically (1–2 years) exposed to high doses (160 mg/kg/day) of finasteride, a selective inhibitor of 5-alpha reducta
Autor:
DAVID H. MINSKER, WALTER J. BAGDON, JAMES S. MACDONALD, RICHARD T. ROBERTSON, DELWIN L. BOKELMAN
Publikováno v:
Toxicological Sciences. 14:461-470
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 14(3)
When enalapril, an angiotensin-converting enzyme (ACE) inhibitor, was orally administered to inseminated rabbits at dosages of 0.1 to 30 mg/kg/day for 13 days in a range-finding study, nephrotoxicity, as measured by elevated serum urea nitrogen conce
Publikováno v:
Toxicology and Applied Pharmacology. 60:142-150
Indacrinone (MK-196), an investigational loop diuretic, was administered to female CRCD rats from Days 6 to 17 of gestation at doses of 40, 80, or 120 mg/kg/day. Dose-related increases in wavy ribs and malformations of the scapula and humerus were ap
Autor:
Douglas Kornbrust, Peter H. Berry, Alfred W. Alberts, Ronald J. Gerson, James S. MacDonald, Michelle W. Kloss, Delwin L. Bokelman, Srinivasa Prahalada
Publikováno v:
The American Journal of Cardiology. 62:J16-J27
Administration of lovastatin to animals at high dosage levels produces a broad spectrum of toxicity. This toxicity is expected based on the critical nature of the target enzyme (HMG CoA reductase) and the magnitude of the dosage levels used. The info
Publikováno v:
Teratology. 28:449-456
Mevinolin is a fungal metabolite, and in the hydroxyacid form, mevinolinic acid, it is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co A) reductase, an enzyme essential in cholesterol biosynthesis. Oral administration of 800 mg/kg/day o
Publikováno v:
Drug Information Journal. 14:82-97
Spontaneous tumors in control F344 and Charles River-CD rats and Charles River CD-1 and B6C3HF1 mice
Publikováno v:
Toxicology Letters. 11:103-110
The incidence of spontaneous neoplasms in outbred, inbred and F1 hybrid strains was compared using the Charles River-CD rat and mouse, the F344 rat, and B6C3HF1 mouse. These strains are commonly used in carcinogenic studies. Each strain has a consist
Autor:
Nancy Moskalski, Richard T. Robertson, Chennekatu P. Peter, D. H. Minsker, Delwin L. Bokelman
Publikováno v:
Biology of the neonate. 41(3-4)
Female rats were administered lead (Pb), as the nitrate salt, on day 17 of pregnancy (5 or 25 mg/kg i.v.) or throughout lactation (5 or 25 mg/kg/day p.o.). There were adverse effects on weights of females receiving Pb on day 17. At 25 mg/kg i.v. gest
Autor:
James A. Majka, Douglas Kornbrust, Albert W. Alberts, Ronald J. Gerson, R. John Stubbs, Delwin L. Bokelman, James S. MacDonald
Publikováno v:
The American journal of medicine. 87(4A)
Simvastatin, a hydroxy-methylglutaryl-coenzyme A reductase inhibitor intended for use as a hypocholesterolemic agent, has undergone a thorough preclinical toxicology evaluation. This review describes preclinical toxicology findings associated with si