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Akademický článek

Development of radiation countermeasure agents for acute radiation syndromes

Autor: Bowen Guan, Deguan Li, Aimin Meng

Publikováno v: Animal Models and Experimental Medicine, Vol 6, Iss 4, Pp 329-336 (2023)

Abstract The risk of internal and external exposure to ionizing radiation (IR) has increased alongside the development and implementation of nuclear technology. Therefore, serious security issues have emerged globally, and there has been an increase

Externí odkaz: https://doaj.org/article/be5f23dc7d3041e1bc2ad5ca2f1c6115

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Akademický článek

Discovery of the radio-protecting effect of Ecliptae Herba, its constituents and targeting p53-mediated apoptosis in vitro and in vivo

Autor: Jiang Wu, Wenfeng Gou, Zhiyun Wang, Huajie Chang, Deguan Li, Wenbin Hou, Changxiao Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1216-1230 (2023)

Radiation protection drugs are often accompanied by toxicity, even amifostine, which has been the dominant radio-protecting drug for nearly 30 years. Furthermore, there is no therapeutic drug for radiation-induced intestinal injury (RIII). This paper

Externí odkaz: https://doaj.org/article/117c1026dbc24e13a41fad6ff3504f48

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Akademický článek

The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation

Autor: Yinping Dong, YuanYang Zhang, Xinyue Wang, Wenxuan Li, Junling Zhang, Lu Lu, Hui Dong, Saijun Fan, Aimin Meng, Deguan Li

Publikováno v: Animal Models and Experimental Medicine, Vol 5, Iss 6, Pp 565-574 (2022)

Abstract Background Gastrointestinal (GI) injury is one of the most common side effects of radiotherapy. However, there is no ideal therapy method except for symptomatic treatment in the clinic. Xuebijing (XBJ) is a traditional Chinese medicine, used

Externí odkaz: https://doaj.org/article/37a858cf13d547aab7c7520bf8236c52

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Akademický článek

Analysis of bowel function, urogenital function, and long-term follow-up outcomes associated with robotic and laparoscopic sphincter-preserving surgical approaches to total mesorectal excision in low rectal cancer: a retrospective cohort study

Autor: Bo Yang, Shangxin Zhang, Xiaodong Yang, Yigao Wang, Deguan Li, Jian Zhao, Yongxiang Li

Publikováno v: World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-12 (2022)

Abstract Objective The present study comparatively analyzed short-term clinical effectiveness and long-term follow-up endpoints associated with robotic-assisted sphincter-preserving surgery (RAS) and laparoscopic-assisted sphincter-preserving surgery

Externí odkaz: https://doaj.org/article/188e40fbf2db4e19bc731ffaad0459ee

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Akademický článek

Author correction to ‘Discovery of the radio-protecting effect of ecliptae herba, its constituents and targeting p53-mediated apoptosis in vitro and in vivo’ [Acta Pharm Sin B 13 (2023) 1216–1230]

Autor: Jiang Wu, Wenfeng Gou, Zhiyun Wang, Huajie Chang, Deguan Li, Wenbin Hou, Changxiao Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2815-2816 (2023)

Externí odkaz: https://doaj.org/article/1177ae89ab71472ca4fb083f6e6d3080

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Akademický článek

Potential role of senescent macrophages in radiation-induced pulmonary fibrosis

Autor: Lulu Su, Yinping Dong, Yueying Wang, Yuquan Wang, Bowen Guan, Yanhua Lu, Jing Wu, Xiaochun Wang, Deguan Li, Aimin Meng, Feiyue Fan

Publikováno v: Cell Death and Disease, Vol 12, Iss 6, Pp 1-12 (2021)

Abstract Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation in clinic with poor prognosis and limited therapeutic options. Previous results have shown that senescent cells, such as fibroblast and type II airway ep

Externí odkaz: https://doaj.org/article/df834d27e1664beeb0a6c42440c0b9a5

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Lysine-specific Demethylase 6A Upregulates Cadherin-1 and Accelerates Gastric Cancer Growth

Autor: Yongxiang Li, Deguan Li, Shangxin Zhang, Qiang Yan

Publikováno v: Current Pharmaceutical Biotechnology. 24:1827-1835

Background: Gastric cancer (GC) ranks fifth among all common malignancies globally. Genetic research has revealed several genes that are frequently dis-regulated in GC, such as lysine-specific demethylase 6A (KDM6A) and cadherin-1 (CDH1). Objective:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffb18fb6f697a59112d3d9ea6a1af325
https://doi.org/10.2174/1389201024666230320100504

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Akademický článek

Application of Laparoscopic Gastric Jejunum Uncut Roux-en-Y Anastomosis

Autor: Chao Yu, Tian Yang, Qiang Yan, Deguan Li, Yigao Wang, Xiaodong Yang, Shangxin Zhang, Yonghong Zhang, Zhen Zhang

Publikováno v: Gastroenterology Research and Practice, Vol 2022 (2022)

Background. Uncut Roux-en-Y gastrojejunostomy, recently developed in China, is useful in the treatment of distal gastric cancer. This study is aimed at comparing laparoscopic gastric jejunum uncut Roux-en-Y anastomosis with conventional anastomosis i

Externí odkaz: https://doaj.org/article/d8151baf73c44cc9ade326416381c391

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Akademický článek

Exosomal miR-183-5p Shuttled by M2 Polarized Tumor-Associated Macrophage Promotes the Development of Colon Cancer via Targeting THEM4 Mediated PI3K/AKT and NF-κB Pathways

Autor: Shangxin Zhang, Deguan Li, Min Zhao, Fei Yang, Changye Sang, Changhong Yan, Zhenjun Wang, Yongxiang Li

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

BackgroundAbnormal accumulation of macrophages in the colon cancer (CC) contribute to its progression. miR-183-5p has been confirmed as an oncogene in CC and this article explores the effect and mechanism of exosomal miR-183-5p enriched by M2-polariz

Externí odkaz: https://doaj.org/article/af2ec5d4224940aaa6f0dcbbb29c6b9b

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