Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias

Autor: Göran Roos, Krystyna H. Chrzanowska, Erik Forestier, Mattias Landfors, Sofie Degerman, W. Nicol Keith, Patrik Rydén, John Revie, Jan Konrad Siwicki, Emma Andersson Evelönn, Magnus Borssén

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 7, Pp 606-615 (2014)
Neoplasia (New York, N.Y.)

We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investi

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