Offspring production of ovarian organoids derived from spermatogonial stem cells by defined factors with chromatin reorganization

Autor: Huacheng Luo, Xiaoyong Li, Geng G. Tian, Dali Li, Changliang Hou, Xinbao Ding, Lin Hou, Qifeng Lyu, Yunze Yang, Austin J. Cooney, Wenhai Xie, Ji Xiong, Hu Wang, Xiaodong Zhao, Ji Wu

Publikováno v: Journal of Advanced Research, Vol 33, Iss , Pp 81-98 (2021)

Introduction: Fate determination of germline stem cells remains poorly understood at the chromatin structure level. Objectives: Our research hopes to develop successful offspring production of ovarian organoids derived from spermatogonial stem cells

Externí odkaz: https://doaj.org/article/0a5f8e74bf8348f4a6d4d68409dca27b

Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators

Autor: Kai Miao, Ligong Lu, Ya Meng, Ren-He Xu, Weiwei Liu, Zhili Ren, Chu-Xia Deng, Guokai Chen, Xiaoyan Wang, Hui Zhong, Wenjun Ni, Chunming Wang

Publikováno v: International Journal of Biological Sciences

Keratinocyte is the predominant cell type in the epidermis of skin, and it provides the protective barrier function for the body. Various signaling pathways have been implicated in keratinocyte differentiation in animal models; However, their tempora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf72bf0c692f4c5e1e4f2cd4f8c3d712
https://doi.org/10.7150/ijbs.44414

Reprogramming, oscillations and transdifferentiation in epigenetic landscapes

Autor: Bivash Kaity, Ratan Sarkar, Mithun K. Mitra, Buddhapriya Chakrabarti

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

Waddington’s epigenetic landscape provides a phenomenological understanding of the cell differentiation pathways from the pluripotent to mature lineage-committed cell lines. In light of recent successes in the reverse programming process there has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c977e2be906a74d61cbcd410f44be7e2
https://doaj.org/article/f8b3e1c4808b4fb79527852698d4d61f

Robust and Reproducible Generation of Induced Neural Stem Cells from Human Somatic Cells by Defined Factors

Autor: Sai Hali, Kwon Ho Hong, Tae Hwan Kwak, Sungmin Kim, Kee-Pyo Kim, Jonghun Kim, Hyeonwoo La, Dong Wook Han, Nam-Hyung Kim, Chan Young Shin

Publikováno v: International Journal of Stem Cells
Kwak, T H, Hali, S, Kim, S, Kim, J, La, H, Kim, K-P, Hong, K H, Shin, C Y, Kim, N-H & Han, D W 2020, ' Robust and Reproducible Generation of Induced Neural Stem Cells from Human Somatic Cells by Defined Factors ', International journal of stem cells, vol. 13, no. 3, pp. 80-92 . https://doi.org/10.15283/ijsc19097

Background and Objectives: Recent studies have described direct reprogramming of mouse and human somatic cells into induced neural stem cells (iNSCs) using various combinations of transcription factors. Although iNSC technology holds a great potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4fac9a81cbc274419ec444534c716
https://pubmed.ncbi.nlm.nih.gov/32114739

Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells

Autor: Nicky Helsen, Philip Roelandt, Ana Rita Mestre Rosa, Paul de Vos, Eric Kalo, Satish Khurana, Manoj Kumar, Marijke M. Faas, Catherine M. Verfaillie, Veerle Vanslembrouck, Sumitava Dastidar, Conny Gysemans, Manmohan Bajaj, Jos Laureys, Renate Akkerman, Rangarajan Sambathkumar

Publikováno v: PLoS ONE, 13(5):e0197046. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197046 (2018)

Multipotent Adult Progenitor Cells (MAPCs) are one potential stem cell source to generate functional hepatocytes or β-cells. However, human MAPCs have less plasticity than pluripotent stem cells (PSCs), as their ability to generate endodermal cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df679d14e9c4398f3388615c4ecc714
https://research.rug.nl/en/publications/e2963d72-0f66-4b4f-ae1a-eb707cc4787f