Zobrazeno 1 - 10
of 354
pro vyhledávání: '"DEEPAK SAMPATH"'
Autor:
Kristin M. Zimmerman Savill, Brian B. Lee, Jason Oeh, Jie Lin, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Zhaoshi Jiang, Eric W. Stawiski, Benjamin Haley, Anneleen Daemen, Xiaojing Wang, Hartmut Koeppen, Zora Modrusan, Scott E. Martin, Deepak Sampath, Kui Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases
Externí odkaz:
https://doaj.org/article/942eedd4f9f14214ba862fbc21b1991f
Autor:
Johannes Riegler, Herman Gill, Annie Ogasawara, Maj Hedehus, Vincent Javinal, Jason Oeh, Gregory Z. Ferl, Jan Marik, Simon Williams, Deepak Sampath, Jill Schartner, Richard A.D. Carano
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 1036-1050 (2019)
Cancer immunotherapies have demonstrated durable responses in a range of different cancers. However, only a subset of patients responds to these therapies. We set out to test if non-invasive imaging of tumor perfusion and vascular inflammation may be
Externí odkaz:
https://doaj.org/article/741a375fc66146b38b3c4feb55c71ce8
Autor:
Raghuveer Singh Mali, Qi Zhang, RosaAnna DeFilippis, Antonio Cavazos, Vinitha Mary Kuruvilla, Jayant Raman, Vidhi Mody, Edna F. Choo, Monique Dail, Neil P. Shah, Marina Konopleva, Deepak Sampath, Elisabeth A. Lasater
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
FLT3 internal tandem duplication (FLT3-ITD) mutations account for ~25% of adult acute myeloid leukemia cases and are associated with poor prognosis. Venetoclax, a selective BCL-2 inhibitor, has limited monotherapy activity in relapsed/refractory acut
Externí odkaz:
https://doaj.org/article/2c93cdcda4114fa79bedeef57cf35957
Autor:
Lina Han, Qi Zhang, Monique Dail, Ce Shi, Antonio Cavazos, Vivian R. Ruvolo, Yang Zhao, Eugene Kim, Mohamed Rahmani, Duncan H. Mak, Sha S. Jin, Jun Chen, Darren C. Phillips, Paul Bottecelli Koller, Rodrigo Jacamo, Jared K. Burks, Courtney DiNardo, Naval Daver, Elias Jabbour, Jing Wang, Hagop M. Kantarjian, Michael Andreeff, Steven Grant, Joel D. Leverson, Deepak Sampath, Marina Konopleva
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
The pathogenesis of acute myeloid leukemia (AML) involves serial acquisition of mutations controlling several cellular processes, requiring combination therapies affecting key downstream survival nodes in order to treat the disease effectively. The B
Externí odkaz:
https://doaj.org/article/e0012766be134ddfaa79a50aa20f66b5
Autor:
Sairy Hernandez, Jing Qing, Rebecca Hong Thibodeau, Xiangnan Du, Summer Park, Hyang-Mi Lee, Min Xu, Soyoung Oh, Armando Navarro, Meron Roose-Girma, Robert J. Newman, Soren Warming, Michelle Nannini, Deepak Sampath, Jeong M. Kim, Jane L. Grogan, Ira Mellman
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 80-94 (2018)
Summary: We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target. We identify kinase-depende
Externí odkaz:
https://doaj.org/article/b83897a71cd24096b600c382ba7050d8
Autor:
Yunzhou Shi, Jason Oeh, Anna Hitz, Maj Hedehus, Jeffrey Eastham-Anderson, Franklin V. Peale, Jr., Patricia Hamilton, Thomas O'Brien, Deepak Sampath, Richard A.D. Carano
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 11, Pp 950-959 (2017)
The effect of anti-angiogenic agents on tumor oxygenation has been in question for a number of years, where both increases and decreases in tumor pO2 have been observed. This dichotomy in results may be explained by the role of vessel normalization i
Externí odkaz:
https://doaj.org/article/1b96baaaac2f4413aedd350f7287303d
Autor:
Ioannis K. Zervantonakis, Claudia Iavarone, Hsing-Yu Chen, Laura M. Selfors, Sangeetha Palakurthi, Joyce F. Liu, Ronny Drapkin, Ursula Matulonis, Joel D. Leverson, Deepak Sampath, Gordon B. Mills, Joan S. Brugge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
High-grade serous ovarian cancers (HGS-OvCa) frequently develop chemotherapy resistance. Here, the authors through a systematic analysis of proteomic and drug response data of 14 HGS-OvCa PDXs demonstrate that targeting apoptosis regulators can impro
Externí odkaz:
https://doaj.org/article/bef99f7f9cf545ffab161533fef245e3
Autor:
Benjamin J Huang, Anica M Wandler, Lauren K Meyer, Monique Dail, Anneleen Daemen, Deepak Sampath, Qing Li, Xinyue Wang, Jasmine C Wong, Joy Nakitandwe, James R Downing, Jinghui Zhang, Barry S Taylor, Kevin Shannon
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008168 (2019)
The lack of predictive preclinical models is a fundamental barrier to translating knowledge about the molecular pathogenesis of cancer into improved therapies. Insertional mutagenesis (IM) in mice is a robust strategy for generating malignancies that
Externí odkaz:
https://doaj.org/article/faa44ed874b34b81857476a8f891244d
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/d1935c5b03e6433ea06acf491e7dc6f2
Autor:
Steven W. Elmore, Chris Tse, Joel D. Leverson, Deepak Sampath, Heather Maecker, Saul H. Rosenberg, Scott L. Ackler, Haichao Zhang, Stephen K. Tahir, Alexander R. Shoemaker, Yu Shen, Morey Smith, Xiaoyu Lin, Paul Nimmer, Michael J. Mitten, Bernard Liu, Xiaoli Huang, Vivek Abraham, Sha Jin, Jun Chen
PDF file - 78K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cb83ab1dce91e1962e4cf133b54b8a
https://doi.org/10.1158/1535-7163.22497211
https://doi.org/10.1158/1535-7163.22497211
