Zobrazeno 1 - 10
of 339
pro vyhledávání: '"DEBBIE C. CRANS"'
Autor:
Andrea Imhoff, Noreena L. Sweeney, Robert D. Bongard, Raulia Syrlybaeva, Ankan Gupta, Edgar Del Carpio, Marat R. Talipov, Costanza Garcia-Keller, Debbie C. Crans, Ramani Ramchandran, Daniel S. Sem
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Introduction: Dual specific phosphatases (DUSPs) are mitogen-activated protein kinase (MAPK) regulators, which also serve as drug targets for treating various vascular diseases. Previously, we have presented mechanistic characterizations of DUSP5 and
Externí odkaz:
https://doaj.org/article/aa4cabe9328a4a3eac7c09b8153c0873
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Introduction: Glioblastoma is a brain cancer difficult to treat but recently mixed-ligand vanadium(V) Schiff base/catecholato complexes have exhibited high in vitro anti-proliferative activity. Hence, we explored the activity of [VVOL1L2], which cont
Externí odkaz:
https://doaj.org/article/a69bdd8e25ec45d1a0a542f147c1e1b3
Autor:
Fabio L. Fontes, Steven A. Rooker, Jamie K. Lynn-Barbe, Michael A. Lyons, Debbie C. Crans, Dean C. Crick
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in case
Externí odkaz:
https://doaj.org/article/875decbc2ba244098f664bd9f51975b7
Autor:
Eucilene K. Batista, Lidiane M. A. de Lima, Dayane A. Gomes, Debbie C. Crans, Wagner E. Silva, Mônica F. Belian, Eduardo C. Lira
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 760 (2024)
Vanadium compounds are known to exert insulin-enhancing activity, normalize elevated blood glucose levels in diabetic subjects, and show significant activity in models of insulin resistance (IR). Faced with insulin resistance, the present work invest
Externí odkaz:
https://doaj.org/article/e0d62a11fca643deb8bca21d403b19e0
Autor:
Irene S. Fahim, Vânia André, Jyotirmayee Mohanty, Rosalia Maria Cigala, Srabanti Ghosh, Luísa M. D. R. S. Martins, Weiwei Han, Anna Maria Papini, Joana Costa, Maela Manzoli, Ottavia Giuffrè, Reshma Rani, Sarish Rehman, Debbie C. Crans, Gabriela Oksdath-Mansilla, Federica Sabuzi
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/7e04842cfefc4fceb6758df5af8a9778
Autor:
Zhaoqi Guo, E Tian, Sen Chen, Jun Wang, Jingyu Chen, Weijia Kong, Debbie C. Crans, Yisheng Lu, Sulin Zhang
Publikováno v:
Antioxidants, Vol 13, Iss 3, p 327 (2024)
Noise-induced hearing loss (NIHL) is a prevalent form of adult hearing impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties
Externí odkaz:
https://doaj.org/article/4643e4b34e104d6bb7dd147c687a1717
Autor:
Santosh Kumar, Steven Sega, Jamie K. Lynn-Barbe, Dannika L. Harris, Jordan T. Koehn, Debbie C. Crans, Dean C. Crick
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1171 (2023)
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Externí odkaz:
https://doaj.org/article/2d5397fce33c46468557652d276537e6
Autor:
Mariana de M. Barbosa, Lidiane M. A. de Lima, Widarlane A. da S. Alves, Eucilene K. B. de Lima, Luzia A. da Silva, Thiago D. da Silva, Kahoana Postal, Mohammad Ramadan, Kateryna Kostenkova, Dayane A. Gomes, Giovana G. Nunes, Michelly C. Pereira, Wagner E. da Silva, Mônica F. Belian, Debbie C. Crans, Eduardo C. Lira
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1232 (2023)
Polyoxovanadates (POV) are a subgroup of polyoxometalates (POM), which are nanosized clusters with reported biological activities. This manuscript describes the first toxicity evaluation of a mixed-valence polyoxovanadate, pentadecavanadate, (Me4N)6[
Externí odkaz:
https://doaj.org/article/eb9c48fc12a3418fbbe1230997a920e4
Autor:
Iman Boukhobza, Debbie C. Crans
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 1198-1228 (2020)
Vanadate and vanadium compounds exist in many environmental, biological and clinical matrices, and despite the need only limited progress has been made on the analysis of vanadium compounds. The vanadium coordination chemistry of different oxidation
Externí odkaz:
https://doaj.org/article/313f203aa1e8496aaa006b283009b5fb
Autor:
Margaret M. Braasch-Turi, Jordan T. Koehn, Kateryna Kostenkova, Cameron Van Cleave, Jacob W. Ives, Heide A. Murakami, Dean C. Crick, Debbie C. Crans
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Lipoquinones, such as ubiquinones (UQ) and menaquinones (MK), function as essential lipid components of the electron transport system (ETS) by shuttling electrons and protons to facilitate the production of ATP in eukaryotes and prokaryotes. Lipoquin
Externí odkaz:
https://doaj.org/article/c31a1e5ecb4448c0acb296bbee978065