Výsledky vyhledávání - "DEAN S. T. HSIEH"

Zero-Order Controlled-Release Polymer Matrices for Micro- and Macromolecules

Autor: Robert Langer, William D. Rhine, Dean S. T. Hsieh

Publikováno v: Journal of Pharmaceutical Sciences. 72:17-22

Theoretical and experimental analyses demonstrate that a hemispheric polymer-drug matrix laminated with an impermeable coating, except for an exposed cavity in the center face, can be used to achieve zero-order release kinetics. Hemispheric systems f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37ba0dcc34101c1c3d3629f4ef120ee
https://doi.org/10.1002/jps.2600720105

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Subcutaneous Controlled Delivery of Estradiol by Compudose° Implants: in Vitro and in vivo Evaluations

Autor: Nancy Smith, Dean S. T. Hsieh, Yie W. Chien

Publikováno v: Drug Development and Industrial Pharmacy. 13:2651-2666

The in vitro and in vivo releases of estradiol from the recently marketed Compudose°-200 and -400 implants were evaluated. These subdermal implants are designed for subcutaneous controlled administration of estradiol in steers for 200- or 400-day gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::196f1e2fd3fe1802009a39edb9551353
https://doi.org/10.3109/03639048709022082

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Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone

Autor: Dean S. T. Hsieh, Richard G. Azizkhan, Chitra Biswas, Romaine R. Bruns, Judah Folkman, Jerome Gross

Publikováno v: Proceedings of the National Academy of Sciences. 78:1176-1180

Medroxyprogesterone, dexamethasone, or cortisone, locally applied in sustained release polymer to rabbit V2 carcinoma implanted in the rabbit cornea, blocked neovascularization and three-dimensional growth of the tumor. These hormones similarly preve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cbfc6516f25083439aa74a82f2a660
https://doi.org/10.1073/pnas.78.2.1176

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Control of release kinetics of macromolecules from polymers

Autor: Robert Langer, Dean S. T. Hsieh, William D. Rhine, Judah Folkman

Publikováno v: Journal of Membrane Science. 7:333-350

Internal and external means for controlling the release rates of large molecules, such as proteins, from ethylene—vinyl acetate copolymer matrices are presented. Internal approaches include alteration of the polymer—drug design, such as changing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dc121a99eb11ad8cec33ef55137ccc8
https://doi.org/10.1016/s0376-7388(00)80477-9

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Chymotrypsin hydrolysis of soybean protein

Autor: Chokyun Rha, Margaret E. Kimball, Dean S. T. Hsieh

Publikováno v: Journal of Agricultural and Food Chemistry. 29:872-874

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36ac3fb6adccebc10ffece81ca9c6964
https://doi.org/10.1021/jf00106a048

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Magnetic modulation of release of macromolecules from polymers

Autor: Robert Langer, Dean S. T. Hsieh, Judah Folkman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 78(3)

Sustained-release systems were made by incorporating bovine serum albumin and magnetic steel beads in an ethylene-vinyl acetate copolymer matrix. When exposed to aqueous medium, the polymer matrix released the albumin slowly and continuously. Applica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3991afda3a8a3cf66995996d4691b7
https://pubmed.ncbi.nlm.nih.gov/6940193

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