Zobrazeno 1 - 10
of 158
pro vyhledávání: '"DE Hogge"'
Publikováno v:
Blood. 81:1465-1470
As a first approach to defining the molecular requirements for supporting human hematopoietic stem cell maintenance and differentiation in vitro, we have analyzed and compared the ability of various factors to support the maintenance and initial diff
Publikováno v:
Blood. 78:666-672
Various growth factors are known to stimulate both early and late stages of human hematopoietic cell development in semisolid assay systems, but their role as microenvironmental regulators is poorly understood. To address this problem, we developed a
Publikováno v:
Blood. 83(12)
Peripheral blood cells (PBCs) collected by leukapheresis after progenitor mobilization with chemotherapy and growth factors have been used successfully to replace marrow autografts in protocols requiring stem-cell support. Moreover, such transplants
Autor:
CJ Eaves, JD Cashman, RJ Kay, GJ Dougherty, T Otsuka, LA Gaboury, DE Hogge, PM Lansdorp, AC Eaves, RK Humphries
Publikováno v:
Blood. 78(1)
Numerous factors that can influence the proliferation and differentiation in vitro of cells at various stages of hematopoiesis have been identified, but the mechanisms used by stromal cells to regulate the cycling status of the most primitive human h
Publikováno v:
Blood. 64:123-130
A patient with Philadelphia chromosome (Ph1) positive chronic myelogenous leukemia (CML) entered a blast crisis localized to lymph nodes. On light microscopy, by morphology and histochemical staining, the blasts were undifferentiated. In spite of ter
Publikováno v:
Blood. 64:937-940
High-dose intravenous gammaglobulin (polyvalent immunoglobulin G) has been shown to be of benefit in some patients with immune thrombocytopenic purpura (ITP), possibly by producing reticuloendothelial system blockade. We studied this approach in pati
Autor:
DE Hogge, RK Humphries
Publikováno v:
Blood. 69:611-617
To study the feasibility of using retroviruses for gene transfer into human hemopoietic cells, various cell types were exposed to virus carrying the gene for neomycin resistance (neor). In preliminary studies using K562 cells as targets, we found tha
The ineffectiveness of random donor platelet transfusion in splenectomized, alloimmunized recipients
Publikováno v:
Blood. 64:253-256
The effect of splenectomy on the response to random donor platelet transfusion in 15 multitransfused thrombocytopenic patients is presented. Eight patients responded poorly, with low corrected platelet count increments at 1 and 24 hours posttransfusi
Publikováno v:
Blood. 74:1915-1922
We used a helper-free recombinant retrovirus carrying the neomycin resistance (neor) gene to investigate methods for improving gene transfer efficiencies to clonogenic hematopoietic progenitor cells of human origin and to assess the possibility of ge
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