Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells.

Autor: Piovesan D; Arcus Biosciences, Hayward, California., de Groot AE; Arcus Biosciences, Hayward, California., Cho S; Arcus Biosciences, Hayward, California., Anderson AE; Arcus Biosciences, Hayward, California., Ray RD; Arcus Biosciences, Hayward, California., Patnaik A; START San Antonio, San Antonio, Texas., Foster PG; Arcus Biosciences, Hayward, California., Mitchell CG; Arcus Biosciences, Hayward, California., Lopez Espinoza AY; Arcus Biosciences, Hayward, California., Zhu WS; Arcus Biosciences, Hayward, California., Stagnaro CE; Arcus Biosciences, Hayward, California., Singh H; Arcus Biosciences, Hayward, California., Zhao X; Arcus Biosciences, Hayward, California., Seitz L; Arcus Biosciences, Hayward, California., Walker NP; Arcus Biosciences, Hayward, California., Walters MJ; Arcus Biosciences, Hayward, California., Sivick KE; Arcus Biosciences, Hayward, California.

Publikováno v: Cancer research [Cancer Res] 2024 Jun 14; Vol. 84 (12), pp. 1978-1995.

Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype.

Autor: de Groot AE; Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N. Wolfe St., Baltimore, MD, USA., Myers KV; Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N. Wolfe St., Baltimore, MD, USA. Electronic address: kaylavmyers@gmail.com., Krueger TEG; Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N. Wolfe St., Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA., Brennen WN; Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N. Wolfe St., Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA., Amend SR; Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Oncology, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA., Pienta KJ; Cancer Ecology Center, The Brady Urological Institute, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N. Wolfe St., Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine, 600 N. Wolfe St., Baltimore, MD, 21287, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins Whiting School of Engineering, 3400 N. Charles St., Baltimore, MD, 21218, USA.

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2022 Oct; Vol. 32, pp. 100830. Date of Electronic Publication: 2022 Aug 05.

CAR-armored-cell therapy in solid tumor treatment.

Autor: Liu, Yan¹ (AUTHOR), Xiao, Lin¹ (AUTHOR), Yang, Mingxuan¹ (AUTHOR), Chen, Xuemei² (AUTHOR), Liu, Hongyue¹ (AUTHOR), Wang, Quanxing^1,3 (AUTHOR), Guo, Meng^1,3 (AUTHOR) guo918meng@163.com, Luo, Jianhua^1,3 (AUTHOR) luojh@immunol.org

Publikováno v: Journal of Translational Medicine. 11/28/2024, Vol. 22 Issue 1, p1-15. 15p.

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses.

Autor: Jaynes JM; College of Agriculture, Environment and Nutrition Sciences, Integrative Biosciences Program, Tuskegee University, Tuskegee, AL 36088, USA.; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA., Sable R; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Ronzetti M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Bautista W; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA., Knotts Z; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Abisoye-Ogunniyan A; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.; Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Li D; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Calvo R; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Dashnyam M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Singh A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Guerin T; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA., White J; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA., Ravichandran S; Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA., Kumar P; Sequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA., Talsania K; CCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA., Chen V; CCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA., Ghebremedhin A; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA., Karanam B; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA., Bin Salam A; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA., Amin R; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA., Odzorig T; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Aiken T; Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA., Nguyen V; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Bian Y; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Zarif JC; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., de Groot AE; James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA., Mehta M; Sequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA., Fan L; Basic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility, Center for Cancer Research of the National Cancer Institute, Frederick, MD 21701, USA., Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Pate N; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA., Abu-Asab M; Section of Histopathology, National Eye Institute, Bethesda, MD 20892, USA., Ferrer M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Southall N; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA., Ock CY; Department of Hemato Oncology, Seoul National University Hospital, Seoul 03080, Korea., Zhao Y; CCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA., Lopez H; MuriGenics Inc., Vallejo, CA 94592, USA., Kozlov S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA., de Val N; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.; Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA., Yates CC; Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov., Baljinnyam B; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov., Marugan J; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov., Rudloff U; Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Feb 12; Vol. 12 (530).

HPTLC Method Development and Validation for Simultaneous Quantification of Purpurin and Alizarin in Rubia cordifolia L. Roots and their Marketed Preparations.

Autor: Ahmad, Rizwan^1,2, Fatima, Zeeshan¹ zfatima@amity.edu, Ali, Sadath³, Dhaneshwar, Suneela⁴ suneeladhaneshwar@rediffmail.com, Ahmad, Sayeed⁵

Publikováno v: Pharmacognosy Research. Jul-Sep2024, Vol. 16 Issue 3, p652-661. 10p.