Zobrazeno 1 - 10
of 350
pro vyhledávání: '"DDIT4"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundCantharidin (CTD) extracted from the traditional Chinese medicine Mylabris has significant therapeutic effects on various tumors. However, the high toxicity of CTD can cause serious liver damage, although the related molecular mechanisms re
Externí odkaz:
https://doaj.org/article/20019ef3ca054d7790e3d0ef60daf62c
Autor:
Hai-tao Lu, Yuan-yuan Jiao, Tian-yu Yu, Jing-xuan Shi, Jing-wei Tian, Gu-ming Zou, Lin Liu, Li Zhuo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction:Diabetic kidney disease (DKD) necessitates innovative therapeutic strategies. This study delves into the role of DNA damage-inducing transcription factor 4 (DDIT4) within the VDR-mTOR pathway, aiming to identify a novel target for DKD dr
Externí odkaz:
https://doaj.org/article/de2aa03187af476ab8fa45a5ac03874f
Autor:
Ha Eun Kim, Jong Yeong Lee, Dong-Hoon Yoo, Hyo-Hyun Park, Eun-Ju Choi, Kyung-Hwa Nam, Jin Park, Jin Kyeong Choi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundImidazole propionate (IMP) is a histidine metabolite produced by some gut microorganisms in the human colon. Increased levels of IMP are associated with intestinal inflammation and the development and progression of cardiovascular disease a
Externí odkaz:
https://doaj.org/article/bf83a1785bcb409aafdb7afd46ee1cb6
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Purpose Solid tumors such as lung adenocarcinoma include not only the tumor cells but also the microenvironment in which the tumor cells continuously interact with each other. An in-depth understanding of the oncological features and tumor m
Externí odkaz:
https://doaj.org/article/7d2a80d4d271477c9019d2f9dbc7f311
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 268, Iss , Pp 115686- (2023)
As one of the most important phthalates, di-isononyl phthalate (DINP) has been widely used as a common plasticizer in the food and personal care products sectors. In our previous study, we found that DINP can induce autophagy of ovarian granulosa cel
Externí odkaz:
https://doaj.org/article/d59a53cd672a4467bbd9a40e916b6853
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 6, Pp 4665-4674 (2023)
Repositioning of aspirin for a more effective breast cancer (BC) treatment requires identification of predictive biomarkers. However, the molecular mechanism underlying the anticancer activity of aspirin remains fully undefined. Cancer cells enhance
Externí odkaz:
https://doaj.org/article/f37968e037ce45bdae63dd099a98c821
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 17, Pp 1175-1189 (2023)
Chengcheng Gai,1,* Xiaohui Xing,1,2,* Yan Song,1 Yijing Zhao,1 Zige Jiang,1 Yahong Cheng,1 Yilei Xiao,2,3 Zhen Wang1,4 1Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shand
Externí odkaz:
https://doaj.org/article/3a4faae57ad34f5a9da7acdc9ed7c35f
Autor:
E. M. Zhidkova, D. D. Grigoreva, E. S. Lylova, V. P. Maksimova, G. R. Sagitova, G. I. Khayrieva, E. S. Trapeznikova, K. I. Kirsanov, M. G. Yakubovskaya, E. A. Lesovaya
Publikováno v:
Сибирский онкологический журнал, Vol 21, Iss 3, Pp 50-60 (2022)
Objective: screening of previously selected DDIT4 inhibitors by their ability to suppress basal and glucocorticoid-induced expression of this gene in breast cancer (BC) cells, as well as evaluation of antiproliferative and cytotoxic effects of the st
Externí odkaz:
https://doaj.org/article/0a86cb5f69c84ab6be5b86b5ee7b8015
Autor:
Maciej Jaśkiewicz, Adrianna Moszyńska, Marcin Serocki, Jarosław Króliczewski, Sylwia Bartoszewska, James F. Collawn, Rafal Bartoszewski
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 454-469 (2022)
The adaptive response to hypoxia involves the transcriptional induction of three transcription factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which dimerize with constitutively expressed beta chains that toge
Externí odkaz:
https://doaj.org/article/fe0213f64af444338ce08c32f8a9c6ed
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
IntroductionDysbiosis of the lower airway flora is associated with lung cancer, of which the relationship between Streptococcus, especially pathogenic Streptococcus pneumoniae (S. pneumoniae), and the progression of lung cancer are unclear.MethodsBro
Externí odkaz:
https://doaj.org/article/a1a584cb6ef9457485a9a14bcad7857b