Zobrazeno 1 - 10
of 19
pro vyhledávání: '"DDAIP"'
Publikováno v:
International Journal of Pharmaceutics. 421:53-62
We investigated the enhancement effect of chemical enhancers and iontophoresis on the in vitro transdermal and transbuccal delivery of lidocaine HCl (LHCl), nicotine hydrogen tartrate (NHT), and diltiazem HCl (DHCl) using porcine skin and buccal tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62aba51ace058d17054832b18bc24906
https://doi.org/10.1016/j.ijpharm.2011.09.025
https://doi.org/10.1016/j.ijpharm.2011.09.025
Publikováno v:
International Journal of Pharmaceutics. 404:66-74
The effect of chemical enhancers and iontophoresis on the in vitro transbuccal delivery of 0.5% ondansetron HCl (ODAN HCl) was investigated using porcine buccal tissue. The chemical enhancers used were dodecyl 2-( N , N -dimethyl amino) propionate (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1eb60f69b50df0f3ff3a23afbc03bb5
https://doi.org/10.1016/j.ijpharm.2010.10.052
https://doi.org/10.1016/j.ijpharm.2010.10.052
Autor:
Alexandr Hrabálek, Michal Novotný, Jakub Novotný, Petra Kovaříková, Barbora Janůšová, Kateřina Vávrová
Publikováno v:
Pharmaceutical Research. 26:811-821
Series of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking chain length and polyfluorination were investigated. In vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4264614844e8e66113c0d5ef77354a
https://doi.org/10.1007/s11095-008-9780-3
https://doi.org/10.1007/s11095-008-9780-3
Autor:
Alexandr Hrabálek, Kateřina Vávrová
Publikováno v:
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement ISBN: 9783662470381
Transdermal drug delivery offers an attractive alternative to conventional routes of drug administration. However, development of transdermal patches for drugs with a molecular mass larger than 500 Da is hindered primarily by low skin permeability. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::467b4f2f2d4eb44d8e5664a90623f990
https://doi.org/10.1007/978-3-662-47039-8_20
https://doi.org/10.1007/978-3-662-47039-8_20
Publikováno v:
Current Medicinal Chemistry. 12:2273-2291
Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10958e594426108d28c12b1afbf6d6d
https://doi.org/10.2174/0929867054864822
https://doi.org/10.2174/0929867054864822
Publikováno v:
International Journal of Pharmaceutics. 271:5-10
Differential scanning calorimetry (DSC) was used to investigate the mechanism of action of a proprietary skin penetration enhancer, dodecyl-2-(N,N-dimethylamino)propionate (DDAIP) in dipalmitoylphosphatidylcholine (DPPC) liposomes. Furthermore, the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9721cfdd1aa7ab75a9bc225534e403ec
https://doi.org/10.1016/j.ijpharm.2003.09.018
https://doi.org/10.1016/j.ijpharm.2003.09.018
Publikováno v:
International Journal of Pharmaceutics. 234:121-128
Miconazole (MCZ) has very low solubility in both water and oil. Permeation rates through shed snakeskin from an aqueous suspension and a mineral oil suspension were 0.5 microg/cm(2)/h and almost none, respectively. When hydrogenated phosphatidylcholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becc715eafe9d81e0104e180e14fa670
https://doi.org/10.1016/s0378-5173(01)00951-6
https://doi.org/10.1016/s0378-5173(01)00951-6
Autor:
Arto Urtti, Lea Pirskanen, Mervi Raisanen, Kirsi Kosonen, Petteri Paronen, T. Marjukka Suhonen, J. Howard Rytting
Publikováno v:
Journal of Controlled Release. 43:251-259
The effect of the penetration enhancers Azone, 1-dodecanol, and dodecyl-2-(N,N-dimethylamino)propionate (DDAIP) on the structural integrity of liposomes composed of stratum corneum (SC) lipids was studied. With increasing enhancer concentration (0–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebee2ffea109b50693efbc9daffc46a6
https://doi.org/10.1016/s0168-3659(96)01495-2
https://doi.org/10.1016/s0168-3659(96)01495-2
Autor:
Přemysl Mladěnka, Jaroslav Roh, Kateřina Vávrová, Barbora Školová, Michal Ríha, Lea Wojnarová, Katarína Tükörová, Barbora Janůšová, Tomáš Šimůnek, Alexandr Hrabálek, Karel Palát, Tomáš Filipský
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 165(2)
Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fba4d527c0c782dfb3f0c9b232162e
https://pubmed.ncbi.nlm.nih.gov/23154194
https://pubmed.ncbi.nlm.nih.gov/23154194
Publikováno v:
Journal of Pharmaceutics & Drug Delivery Research.
Enhancing the Skin Flux of Tolnaftate Utilizing the Novel Excipient, Dodecyl-2-N, NDimethylaminopropionate (DDAIP) Penetration of drug through the stratum corneum to reach the underlying epidermal and dermal layers is a critical step for effective th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69a3c1613f2a1c366101c6fb5fbfa21
https://doi.org/10.4172/2325-9604.1000102
https://doi.org/10.4172/2325-9604.1000102