Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways

Autor: A Tam, J Kulkarni, K An, L Li, DR Dorscheid, GK Singhera, P Bernatchez, GSD Reid, KYT Chan, D Witzigmann, PR Cullis, DD Sin, CJ Lim

Publikováno v: European Journal of Pharmaceutical Sciences. 176:106234

Lipid nanoparticles (LNP) have been successfully used as a platform technology for delivering nucleic acids to the liver. To broaden the application of LNPs in targeting non-hepatic tissues, we developed LNP-based RNA therapies (siRNA or mRNA) for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539cd56cf8b81e743f23246351a09222
https://doi.org/10.1016/j.ejps.2022.106234

Beta-blockers and health-related quality of life in patients with peripheral arterial disease and COPD

Autor: Yvette Gestel, Sanne Hoeks, Dd, Sin, Stam, H., Frans Mertens, Jj, Bax, Ron Van Domburg, Poldermans, D.

Publikováno v: The International Journal of Chronic Obstructive Pulmonary Disease, 4, 177-183. Dove Medical Press Ltd.
EUR Research Portal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7a81930a3a2d4c1193affc360460464e
https://pure.eur.nl/en/publications/c6375fbf-d59c-4a16-9907-04696f6b08d8

GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD.

Autor: Singh D; University of Manchester, Manchester University NHS Foundation Hospital Trust, Manchester, UK dsingh@meu.org.uk., Stockley R; University Hospital, Birmingham, UK., Anzueto A; South Texas Veterans Health Care System University of Texas, Health San Antonio, Texas, USA., Agusti A; Respiratory Institute Hospital Clinic, IDIBAPS Univ. Barcelona and Ciberes Barcelona, Spain., Bourbeau J; McGill University Health Centre, McGill University, Montreal, QC, Canada., Celli BR; Harvard Medical School Boston, Massachusetts, USA., Criner GJ; Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Han MK; University of Michigan Ann Arbor, MI, USA., Martinez FJ; Weill Cornell Medical Center/ New York-Presbyterian Hospital New York, NY, USA., Montes de Oca M; Hospital Universitario de Caracas, Universidad Central de Venezuela, Centro Médico de Caracas, Caracas, Venezuela., Ozoh OB; College of Medicine, University of Lagos, Lagos, Nigeria., Papi A; Respiratory Medicine, University of Ferrara, Ferrara, Italy., Pavord I; Respiratory Medicine Unit and Oxford Respiratory NIHR Biomedical Research Centre, Nuffield Department of Medicine University of Oxford Oxford, UK., Roche N; Pneumologie, Hôpital Cochin AP-HP.Centre - Université Paris Cité UMR 1016 Institut Cochin Paris, France., Salvi S; Pulmocare Research and Education (PURE) Foundation, Pune, India., Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia Division of Respiratory Medicine, Vancouver, BC, Canada., Troosters T; Department of Rehabilitation Sciences & Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium., Wedzicha J; National Heart & Lung Institute Imperial College London, United Kingdom., Zheng J; National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Volgelmeier C; Department of Medicine, Pulmonary and Critical Care Medicine, University Hospital Giessen and Marburg, German Center for Lung Research (DZL), University of Marburg Marburg, Germany., Halpin D; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter Devon, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Dec 05. Date of Electronic Publication: 2024 Dec 05.

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies.

Autor: Moll M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary, Critical Care, Sleep and Allergy, Veterans Affairs Boston Healthcare System, West Roxbury, MA, 02123, USA; Harvard Medical School, Boston, MA, 02115, USA., Hecker J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Platig J; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Zhang J; The Pulmonary Center, Boston University Medical Center, Boston, MA 02118, USA., Ghosh AJ; Division of Pulmonary, Critical Care, and Sleep Medicine, SUNY Upstate Medical University, Syracuse, NY, 13210, USA., Pratte KA; Department of Biostatistics, National Jewish Health, Denver, CO, 80206, USA., Wang RS; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Hill D; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA., Konigsberg IR; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Chiles JW 3rd; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA., Hersh CP; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Castaldi PJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA; Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Glass K; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Dy JG; Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA., Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital, and Department of Medicine (Respiratory Division), University of British Columbia, Vancouver, BC, Canada., Tal-Singer R; Global Allergy and Airways Patient Platform, Vienna, Austria., Mouded M; Novartis Institute for Biomedical Research, Cambridge, MA, USA., Rennard SI; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Nebraska, Omaha, NE, 68198, USA., Anderson GP; Lung Health Research Centre, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia., Kinney GL; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Bowler RP; Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, 80206, USA., Curtis JL; Division of Pulmonary and Critical Care Medicine, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA; Medical Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48109, USA., McDonald ML; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 701, 19th Street S., LHRB 440, Birmingham, AL, 35233, USA; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA., Hobbs BD; Regeneron Pharmaceutical, Tarrytown, NY, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA. Electronic address: remhc@channing.harvard.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Dec; Vol. 110, pp. 105429. Date of Electronic Publication: 2024 Nov 06.

Food for thought: optimal diet in patients with asthma and chronic obstructive pulmonary disease.

Autor: Vameghestahbanati M; Department of Medicine, McGill University and McGill University Health Centre Research, Institute, Montreal, Quebec., Wang CJ; Centre for Heart Lung Innovation, St. Paul's Hospital., Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital.; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Publikováno v: Current opinion in pulmonary medicine [Curr Opin Pulm Med] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29.