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Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI- cell population

Autor: M Rottem, T Okada, JP Goff, DD Metcalfe

Publikováno v: Blood. 84:2489-2496

Mast cells may be cultured from human peripheral blood in the presence of recombinant human stem cell factor (rhSCF). The characteristics of the cells in peripheral blood that give rise to mast cells are unknown. Because mast cell precursors in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93023be4187fbf1d8543dba3a8f57733
https://doi.org/10.1182/blood.v84.8.2489.bloodjournal8482489

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Kinetics of the appearance of Fc epsilon RI-bearing cells in interleukin-3-dependent mouse bone marrow cultures: correlation with histamine content and mast cell maturation

Autor: M Rottem, S Barbieri, JP Kinet, DD Metcalfe

Publikováno v: Blood. 79:972-980

While it is known that mast cells arise from pluripotential hematopoietic cells and express their mature phenotypes in tissues, the sequence of events in maturation is incompletely understood. To study early mast cells, we sorted cells from interleuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edd5a385c9ec5289b160531efe1e297d
https://doi.org/10.1182/blood.v79.4.972.bloodjournal794972

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Akademický článek

MITF Downregulation Induces Death in Human Mast Cell Leukemia Cells and Impairs IgE-Dependent Degranulation.

Autor: Proaño-Pérez, Elizabeth^1,2,3 (AUTHOR), Ollé, Laia^1,2 (AUTHOR), Guo, Yanru^1,2 (AUTHOR), Aparicio, Cristina¹ (AUTHOR), Guerrero, Mario¹ (AUTHOR), Muñoz-Cano, Rosa^2,4,5 (AUTHOR), Martin, Margarita^1,2,5 (AUTHOR) martin_andorra@ub.edu

Publikováno v: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3515. 13p.

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Functional and biochemical characterization of rat bone marrow derived mast cells

Autor: David Broide, Dd, Metcalfe, Si, Wasserman

Publikováno v: Europe PubMed Central

The functional and biochemical characterization of rat bone marrow derived mast cells (RBMMC) confirms both species-related differences between rat and mouse bone marrow-derived mast cells (MBMMC) as well as mast cell heterogeneity in a single specie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1103c6ef18ab6827ea6399583e79f45e
https://pubmed.ncbi.nlm.nih.gov/2974057

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Production of granulocyte-macrophage colony-stimulating factor by primary cultures of unstimulated rat microvascular endothelial cells

Autor: DG Malone, JH Pierce, JP Falko, DD Metcalfe

Publikováno v: Blood. 71(3)

Small vessel (microvascular) endothelial cells are in close contact with hematopoietic progenitor cells in the bone marrow and therefore may have an important role in hematopoiesis. Although other studies have shown that endothelial cells produce var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b99a578fb9ade9f379a43002c723ef0
https://pubmed.ncbi.nlm.nih.gov/3278753

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Endothelins belong to the assortment of mast cell-derived and mast cell-bound cytokines

Autor: Hannelore Ehrenreich, Pr, Burd, Rottem M, Hültner L, Jb, Hylton, Garfield M, Je, Coligan, Dd, Metcalfe, As, Fauci

Publikováno v: Europe PubMed Central

Local accumulation of endothelins (ETs) as cytokine-like factors via autocrine/paracrine mechanisms seems to represent an important aspect of their pathophysiological action. This assumption prompted us to investigate mast cells as a possible source

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::04bacdea719402df663a39f2b325b25f
http://europepmc.org/abstract/med/1313283

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Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology

Autor: Cem Akin, Lb, Schwartz, Kitoh T, Obayashi H, As, Worobec, Lm, Scott, Dd, Metcalfe

Publikováno v: Europe PubMed Central

Systemic mastocytosis is a disease of mast cell proliferation that may be associated with hematologic disorders. There are no features on examination that allow the diagnosis of systemic disease, and mast cell-derived mediators, which may be elevated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5e5c5a5f299c65d64a7b7ac7258057f9
http://europepmc.org/abstract/med/10942367

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