Zobrazeno 1 - 10
of 8 869
pro vyhledávání: '"DCs, Dendritic cells"'
Autor:
Yun Dai, Zhuo Yu, Dandan Sun, Hao Yang, Liu Song, Shulan Han, Caitriona M. O'Driscoll, Jianfeng Guo, Di Chu, Jie Ma, Yifang Zou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 378-393 (2022)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer (CRC). Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6dd4b7090c45d73c9ae54ee9fd9f2
http://www.sciencedirect.com/science/article/pii/S2211383521002173
http://www.sciencedirect.com/science/article/pii/S2211383521002173
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173
https://doi.org/10.1016/j.apsb.2021.04.001
https://doi.org/10.1016/j.apsb.2021.04.001
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 92-106 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 92-106 (2022)
Nanoparticulate drug delivery systems (Nano-DDSs) have emerged as possible solution to the obstacles of anticancer drug delivery. However, the clinical outcomes and translation are restricted by several drawbacks, such as low drug loading, premature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a15ad3659d8f272ed8ada8a0844beb
http://europepmc.org/articles/PMC8799886
http://europepmc.org/articles/PMC8799886
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e3a12774af1e45fb188f205ad9bdc
https://doi.org/10.1016/j.bioactmat.2020.12.010
https://doi.org/10.1016/j.bioactmat.2020.12.010
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 976-988 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 976-988 (2021)
Graphical abstract
Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the
Chemokines are crucial inflammatory mediators needed during an immune response to clear pathogens. However, their excessive release is the main cause of hyperinflammation. In the recent COVID-19 outbreak, chemokines may be the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a813633e01cb0494554b46fedd72c61
http://europepmc.org/articles/PMC7859556
http://europepmc.org/articles/PMC7859556
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. Particularly, the checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946
http://www.sciencedirect.com/science/article/pii/S2211383519316946
Autor:
Caifang Gao, Peng Liu, Hongguo Chen, Xu Wu, Xudong Tang, Yitao Wang, Chi Teng Vong, Shengpeng Wang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2798-2818 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2798-2818 (2021)
Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization. With no curative therapy for IBD at present, the development of effective therapeutics is highly advocated. Drug de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf33f667c4f81b143c5ccef5cfb99fc
http://europepmc.org/articles/PMC8463263
http://europepmc.org/articles/PMC8463263
Autor:
Wen Li, Hiroshi Kurihara, Chang Yan, Zhuo Luo, Rong-Rong He, Yi-Fang Li, Robert Dallmann, Xue Li
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)
Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e8bd4a9163466778ab2c0a48ebad5d
https://doi.org/10.1016/j.apsb.2019.06.005
https://doi.org/10.1016/j.apsb.2019.06.005
Autor:
Christine M. Akamine, Hana M. El Sahly
Publikováno v:
Translational Research
The mRNA therapeutics have been studied since the 1970s and the currently available mRNA vaccines against COVID-19 are the culmination of decades of scientific research. The mRNA vaccines BNT162b2 and mRNA-1273 have played a key role in our global re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fb17a5ba87457527cd1ba281170c15
https://pubmed.ncbi.nlm.nih.gov/34954088
https://pubmed.ncbi.nlm.nih.gov/34954088
Autor:
Hae Li Ko, Kyung Won Kang, Manki Song, Sang-Myeong Lee, Hye-Lim Park, Jae-Ouk Kim, Hye-Jung Kim, Jae-Hwan Nam, Eui-Cheol Shin, Hye Won Kwak, Seung Rok Ryu, Hyo Jung Park, Dae Gwin Jeong, Rhoon-Ho Kim, Min Ho Cha, Hun Kim
Publikováno v:
Vaccine
Highlights • RNA adjuvant was developed from the CrPV intergenic region IRES. • The RNA adjuvant functioned as an adjuvant with protein-based vaccines. • The RNA adjuvant increased vaccine efficacy and induced balanced Th1/Th2 response. • The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bee6776ec07d79debcbc88725f48c1
https://doi.org/10.1016/j.vaccine.2019.07.070
https://doi.org/10.1016/j.vaccine.2019.07.070