Výsledky vyhledávání - "DCT, distal convoluted tubule"

Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension

Autor: Nur Farah Meor Azlan, Jinwei Zhang, Maarten P. Koeners

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1117-1128 (2021)

Hypertension is the largest risk factor for cardiovascular disease, the leading cause of mortality worldwide. As blood pressure regulation is influenced by multiple physiological systems, hypertension cannot be attributed to a single identifiable eti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cf89adceb9ad5521b4a16ae65dbf60
https://doi.org/10.1016/j.apsb.2020.09.009

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High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter

Autor: Sathish K. Murali, Marleen L. A. Kortenoeven, Henrik Dimke, Robert A. Fenton, Cristina Esteva-Font, Søren Brandt Poulsen

Publikováno v: Kortenoeven, M L A, Esteva-Font, C, Dimke, H, Poulsen, S B, Murali, S K & Fenton, R A 2021, ' High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter ', The Journal of biological chemistry, vol. 297, no. 2, 100915 . https://doi.org/10.1016/j.jbc.2021.100915
Kortenoeven, M L A, Esteva-Font, C, Dimke, H, Poulsen, S B, Murali, S K & Fenton, R A 2021, ' High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter ', The Journal of Biological Chemistry, vol. 297, no. 2, 100915 . https://doi.org/10.1016/j.jbc.2021.100915
The Journal of Biological Chemistry

The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulating blood pressure (BP) and K+ homeostasis. During hyperkalemia, reduced NCC phosphorylation and total NCC abundanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373a624fd8fd142a9c740843c2731f0e
https://findresearcher.sdu.dk:8443/ws/files/184489721/PIIS0021925821007158.pdf

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Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells

Autor: Valinsky, William C., Touyz, Rhian M., Shrier, Alvin

Publikováno v: Biochimica et Biophysica Acta

Thiazides block Na+ reabsorption while enhancing Ca2+ reabsorption in the kidney. As previously demonstrated in immortalized mouse distal convoluted tubule (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26040fe1004cb9201bae5d75a331247b
http://europepmc.org/articles/PMC5482324

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The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Autor: Thomas Macartney, Youcef Mehellou, Frances-Rose Schumacher, Axel Knebel, Akihito Ohta, Dario R. Alessi, Nicola T. Wood, Clare Johnson, Thimo Kurz

Publikováno v: Biochemical Journal

The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an important role in controlling mammalian blood pressure by modulating the activity of ion co-tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070788786abe18caa6db90ba6b935486
https://doi.org/10.1042/bj20121903

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WNK4 is the major WNK positively regulating NCC in the mouse kidney

Autor: Eisei Sohara, Sei Sasaki, Tatemitsu Rai, Daiei Takahashi, Muhammad Zakir Hossain Khan, Yuya Araki, Moko Zeniya, Naohiro Nomura, Takayasu Mori, Shinichi Uchida

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 34, Iss 3, p e00107 (2014)

By analysing the pathogenesis of a hereditary hypertensive disease, PHAII (pseudohypoaldosteronism type II), we previously discovered that WNK (with-no-lysine kinase)–OSR1/SPAK (oxidative stress-responsive 1/Ste20-like proline/alanine-rich kinase)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b847b47bb2ffca2579529be9bda1a76
https://doi.org/10.1042/bsr20140047

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Akademický článek

Regulatory control of the Na-Cl co-transporter NCC and its therapeutic potential for hypertension.

Autor: Meor Azlan NF; Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK., Koeners MP; Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK., Zhang J; Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 May; Vol. 11 (5), pp. 1117-1128. Date of Electronic Publication: 2020 Sep 22.

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Akademický článek

Magnesium homeostasis in cattle: absorption and excretion.

Autor: Martens H; 1Institute for Veterinary Physiology,Freie Universität Berlin,Berlin,Germany., Leonhard-Marek S; 2Department of Physiology,University of Veterinary Medicine,Foundation,Hannover,Germany., Röntgen M; 3Institute of Muscle Biology and Growth,Leibniz Institute for Farm Animal Biology (FBN),18196 Dummerstorf,Germany., Stumpff F; 1Institute for Veterinary Physiology,Freie Universität Berlin,Berlin,Germany.

Publikováno v: Nutrition research reviews [Nutr Res Rev] 2018 Jun; Vol. 31 (1), pp. 114-130. Date of Electronic Publication: 2018 Jan 10.

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