Zobrazeno 1 - 10 of 1 445 pro vyhledávání: '"DCT, distal convoluted tubule"'
1
Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension
Autor: Nur Farah Meor Azlan, Jinwei Zhang, Maarten P. Koeners
Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1117-1128 (2021)
Hypertension is the largest risk factor for cardiovascular disease, the leading cause of mortality worldwide. As blood pressure regulation is influenced by multiple physiological systems, hypertension cannot be attributed to a single identifiable eti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cf89adceb9ad5521b4a16ae65dbf60
https://doi.org/10.1016/j.apsb.2020.09.009
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2
High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter
Autor: Sathish K. Murali, Marleen L. A. Kortenoeven, Henrik Dimke, Robert A. Fenton, Cristina Esteva-Font, Søren Brandt Poulsen
Publikováno v: Kortenoeven, M L A, Esteva-Font, C, Dimke, H, Poulsen, S B, Murali, S K & Fenton, R A 2021, ' High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter ', The Journal of biological chemistry, vol. 297, no. 2, 100915 . https://doi.org/10.1016/j.jbc.2021.100915
Kortenoeven, M L A, Esteva-Font, C, Dimke, H, Poulsen, S B, Murali, S K & Fenton, R A 2021, ' High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter ', The Journal of Biological Chemistry, vol. 297, no. 2, 100915 . https://doi.org/10.1016/j.jbc.2021.100915
The Journal of Biological Chemistry
The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulating blood pressure (BP) and K+ homeostasis. During hyperkalemia, reduced NCC phosphorylation and total NCC abundanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373a624fd8fd142a9c740843c2731f0e
https://findresearcher.sdu.dk:8443/ws/files/184489721/PIIS0021925821007158.pdf
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3
Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells
Autor: Valinsky, William C., Touyz, Rhian M., Shrier, Alvin
Publikováno v: Biochimica et Biophysica Acta
Thiazides block Na+ reabsorption while enhancing Ca2+ reabsorption in the kidney. As previously demonstrated in immortalized mouse distal convoluted tubule (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26040fe1004cb9201bae5d75a331247b
http://europepmc.org/articles/PMC5482324
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5
The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
Autor: Thomas Macartney, Youcef Mehellou, Frances-Rose Schumacher, Axel Knebel, Akihito Ohta, Dario R. Alessi, Nicola T. Wood, Clare Johnson, Thimo Kurz
Publikováno v: Biochemical Journal
The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an important role in controlling mammalian blood pressure by modulating the activity of ion co-tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070788786abe18caa6db90ba6b935486
https://doi.org/10.1042/bj20121903
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6
Akademický článek
The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney disease.
Autor: Smith, Abigail O.1,2 (AUTHOR), Frantz, William Tyler1,2 (AUTHOR), Preval, Kenley M.1,2 (AUTHOR), Edwards, Yvonne J. K.1 (AUTHOR), Ceol, Craig J.1 (AUTHOR), Jonassen, Julie A.3 (AUTHOR), Pazour, Gregory J.1 (AUTHOR) gregory.pazour@umassmed.edu
Publikováno v: PLoS Genetics. 12/12/2024, Vol. 20 Issue 12, p1-23. 23p.
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8
Akademický článek
EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney disease.
Autor: Lv, Jiayi1 (AUTHOR), Lan, Bingxue2,3 (AUTHOR), Fu, Lili1 (AUTHOR), He, Chaoran3 (AUTHOR), Zhou, Wei4 (AUTHOR), Wang, Xi5,6 (AUTHOR), Zhou, Chenchen7 (AUTHOR), Mao, Zhiguo1 (AUTHOR) maozhiguo93@163.com, Chen, Yupeng3 (AUTHOR) ychen@tmu.edu.cn, Mei, Changlin1 (AUTHOR) changlinmei@smmu.edu.cn, Xue, Cheng1 (AUTHOR) chengxia1568@126.com
Publikováno v: Journal of Translational Medicine. 10/29/2024, Vol. 22 Issue 1, p1-23. 23p.
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9
Akademický článek
Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis.
Autor: Zhang, Yi‐Lin1 (AUTHOR), Tang, Tao‐Tao1 (AUTHOR), Wang, Bin1 (AUTHOR), Wen, Yi1 (AUTHOR), Feng, Ye1,2 (AUTHOR), Yin, Qing1 (AUTHOR), Jiang, Wei1 (AUTHOR), Zhang, Yue1 (AUTHOR), Li, Zuo‐Lin1 (AUTHOR), Wu, Min1 (AUTHOR), Wu, Qiu‐Li1 (AUTHOR), Song, Jing1 (AUTHOR), Crowley, Steven D.3 (AUTHOR), Lan, Hui‐Yao4 (AUTHOR), Lv, Lin‐Li1 (AUTHOR) lvlinli@seu.edu.cn, Liu, Bi‐Cheng1 (AUTHOR) liubc64@seu.edu.cn
Publikováno v: Advanced Science. 10/16/2024, Vol. 11 Issue 38, p1-26. 26p.
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10
Akademický článek
HNF1B Transcription Factor: Key Regulator in Renal Physiology and Pathogenesis.
Autor: Sánchez-Cazorla, Eloísa1,2 (AUTHOR) eloisasancaz@gmail.com, Carrera, Noa1,2,3 (AUTHOR) noa.carrera.cachaza@sergas.es, García-González, Miguel Ángel1,2,3 (AUTHOR) noa.carrera.cachaza@sergas.es
Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10609. 15p.
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