Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions

Autor: Haleh Davanian, Margaret Chen, Soo Aleman, Anthony T. Tan, Katie Healy, Antonio Bertoletti, Andrea Pavesi, Tiphaine Parrot, Johan K. Sandberg, Susanne E Reinsbach, Michał J. Sobkowiak

Publikováno v: JHEP Reports, Vol 3, Iss 4, Pp 100318-(2021)
JHEP Reports

Background & Aims Virus-specific T cell dysfunction is a common feature of HBV-related hepatocellular carcinoma (HBV-HCC). Conventional T (ConT) cells can be redirected towards viral antigens in HBV-HCC when they express an HBV-specific receptor; how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd0342307cbb74465ae0246e43031e6
https://doi.org/10.1016/j.jhepr.2021.100318

Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions.

Autor: Healy K; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden., Pavesi A; Institute of Molecular and Cell Biology, A∗STAR, Singapore., Parrot T; Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Sobkowiak MJ; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden., Reinsbach SE; Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Gothenburg, Sweden., Davanian H; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden., Tan AT; Programme of Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Aleman S; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Sandberg JK; Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden., Bertoletti A; Programme of Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Sällberg Chen M; Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2021 Jun 11; Vol. 3 (4), pp. 100318. Date of Electronic Publication: 2021 Jun 11 (Print Publication: 2021).