The nucleocytosolic O-fucosyltransferase SPINDLY affects protein expression and virulence in Toxoplasma gondii

Autor: Giulia Bandini, Christopher M. West, Hanke van der Wel, John Samuelson, Carolina Agop-Nersesian, Hyun W. Kim, Msano Mandalasi

Publikováno v: The Journal of Biological Chemistry

Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a conserved feature of eukaryotes. While in animals, O-GlcNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen Toxoplasma gondii transfers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47e5dc6ed26363cc16577e4b3babc28
https://doi.org/10.1074/jbc.ra120.015883

Spatiotemporal changes of tissue glycans depending on localization in cardiac aging.

Autor: Itakura Y; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Hasegawa Y; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Kikkawa Y; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.; Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Murakami Y; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.; Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan., Sugiura K; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.; Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Nagai-Okatani C; Cellular and Molecular Biotechnology Research Institute, National Institutes of Advanced Industrial Science and Technology, 5 Central, Tsukuba, 1-1-1 Higashi, Tsukuba-city, Ibaraki 305-8565, Japan., Sasaki N; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Umemura M; Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan., Takahashi Y; Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan., Kimura T; Laboratory of Stem Cell Biology, Department of Biosciences, Kitasato University School of Science, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan., Kuno A; Cellular and Molecular Biotechnology Research Institute, National Institutes of Advanced Industrial Science and Technology, 5 Central, Tsukuba, 1-1-1 Higashi, Tsukuba-city, Ibaraki 305-8565, Japan., Ishiwata T; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan., Toyoda M; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.

Publikováno v: Regenerative therapy [Regen Ther] 2023 Jan 07; Vol. 22, pp. 68-78. Date of Electronic Publication: 2023 Jan 07 (Print Publication: 2023).