Zobrazeno 1 - 10
of 696
pro vyhledávání: '"DAX1"'
Inhibition of GLI Transcriptional Activity and Prostate Cancer Cell Growth and Proliferation by DAX1
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 5347-5361 (2023)
The Hedgehog (Hh) signaling pathway plays an essential role in the initiation and progression of prostate cancer. This is mediated by transcriptional factors belonging to the GLI (glioma-associated oncogene) family, which regulate downstream targets
Externí odkaz:
https://doaj.org/article/e45d554d7f8148df9c4a22c542b89c8c
Autor:
Wanqi Zheng, Ying Duan, Yu Xia, Lili Liang, Zhuwen Gong, Ruifang Wang, Deyun Lu, Kaichuang Zhang, Yi Yang, Yuning Sun, Huiwen Zhang, Lianshu Han, Zizhen Gong, Bing Xiao, Wenjuan Qiu
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-14 (2023)
Abstract Background X-linked adrenal hypoplasia congenita (AHC) is a rare disorder characterized by primary adrenal insufficiency (PAI) and hypogonadotropic hypogonadism (HH), with limited clinical and genetic characterization. Methods The clinical,
Externí odkaz:
https://doaj.org/article/f9707ff88ac3441c84a4bef5ede3aeb3
Autor:
Miwa Watanabe, Hiromichi Kosaka, Masamori Sugawara, Michihiro Maemoto, Yoko Ono, Takeshi Uemori, Ryota Shizu, Kouichi Yoshinari
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9802-9814 (2023)
Abstract Objective EWS‐FLI1 is the most common oncogenic fusion protein in Ewing's sarcoma family tumors (ESFTs). DAX1, an orphan member of the nuclear receptor superfamily, is up‐regulated by EWS‐FLI1 and plays a key role in the transformed ph
Externí odkaz:
https://doaj.org/article/906d4085a139491bab6438486a342210
Akademický článek
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Autor:
Hong Ouyang, Bo Chen, Na Wu, Ling Li, Runyu Du, Meichen Qian, Wenshu Yu, Yujing He, Xinyan Liu
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Most patients with congenital adrenal hypoplasia (AHC) develop symptoms during infantile and juvenile periods, with varying clinical manifestations. AHC is a disease that is easily misdiagnosed as Addison’s disease or congenital
Externí odkaz:
https://doaj.org/article/7f3f12fef4014f9181fd2b64a513de76
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Nuclear receptor subfamily 0 group B member 1 gene (NR0B1) encodes an orphan nuclear receptor that plays a critical role in the development and regulation of the adrenal gland and hypothalamic–pituitary–gonadal axis. In this study, we report a no
Externí odkaz:
https://doaj.org/article/2e86986673414a9a9810c35e4eb47197
Autor:
Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9332 (2023)
Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX1) is an orphan nuclear receptor encoded by the NR0B1 gene. The functional study showed that DAX1 is a physiologically significant target for EWS/FLI1-medi
Externí odkaz:
https://doaj.org/article/41613c7d097d4e60a8d15a00ca0ab6bc
Akademický článek
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Autor:
Hyo-Jeong Yun, Young-Joo Suh, Yu-Bin Kim, Eun-Jung Kang, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Jung-Ran Noh, Hueng-Sik Choi, Yong-Hoon Kim, Chul-Ho Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14009 (2022)
Fulminant hepatitis is characterized by rapid and massive immune-mediated liver injury. Dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1; NR0B1) represses the transcription of various genes.
Externí odkaz:
https://doaj.org/article/06dea51e90a34a03bffdc8a7e63d9ae4
Publikováno v:
Molecular Cytogenetics, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Background 46,XX male syndrome is a rare disorder that usually causes infertility. This study was established to identify the genetic causes of this condition in a series of 46,XX males through the combined application of cytogenetic and mol
Externí odkaz:
https://doaj.org/article/8050833831f042f295f27521c14dc57a