Average causal effect estimation via instrumental variables: the no simultaneous heterogeneity assumption

Autor: Hartwig, F. P., Wang, L., Smith, G. Davey, Davies, N. M.

Background: Instrumental variables (IVs) can be used to provide evidence as to whether a treatment X has a causal effect on an outcome Y. Even if the instrument Z satisfies the three core IV assumptions of relevance, independence and the exclusion re

Externí odkaz: http://arxiv.org/abs/2010.10017

A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology

Autor: DE VRIES, P. S., SABATER-LLEAL, M., HUFFMAN, J. E., MARTEN, J., Song, C., PANKRATZ, N., BARTZ, T. M., DE HAAN, H. G., DELGADO, G. E., EICHER, J. D., MARTINEZ-PEREZ, A., WARD-CAVINESS, C. K., BRODY, J. A., CHEN, M. H., DE MAAT, M. P. M., Franberg, M., Gill, D., KLEBER, M. E., Rivadeneira, F., SORIA, J. M., Tang, W., TOFLER, G. H., UITTERLINDEN, A. G., van Hylckama Vlieg, A., SESHADRI, S., BOERWINKLE, E., DAVIES, N. M., GIESE, A. K., IKRAM, M. K., KITTNER, S. J., MCKNIGHT, B., PSATY, B. M., REINER, A. P., Sargurupremraj, Muralidharan, TAYLOR, K. D., CONSORTIUM, Invent, FORNAGE, M., HAMSTEN, A., MARZ, W., ROSENDAAL, F. R., SOUTO, J. C., DEHGHAN, A., JOHNSON, A. D., MORRISON, A. C., O'DONNELL, C. J., SMITH, N. L.

Publikováno v: Blood
Blood, American Society of Hematology, 2019, 133 (9), pp.967-977. ⟨10.1182/blood-2018-05-849240⟩

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of nine genome-wide association studies of plasma FVII levels (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fb27ae87ead6edee8f5148440dd3487d
http://hdl.handle.net/20.500.12278/39310

An epigenome-wide association study meta-analysis of educational attainment

Autor: Karlsson Linnér, R, Marioni, R E, Rietveld, C A, Simpkin, A J, Davies, N M, Watanabe, K, Armstrong, N J, Auro, K, Baumbach, C, Bonder, M J, Buchwald, J, Fiorito, G, Ismail, K, Iurato, S, Joensuu, A, Karell, P, Kasela, S, Lahti, J, McRae, A F, Mandaviya, P R, Seppälä, I, Wang, Y, Baglietto, L, Binder, E B, Harris, S E, Hodge, A M, Horvath, S, Hurme, M, Johannesson, M, Latvala, A, Mather, K A, Medland, S E, Metspalu, A, Milani, L, Milne, R L, Pattie, A, Pedersen, N L, Peters, A, Polidoro, S, Räikkönen, K, Severi, G, Starr, J M, Stolk, L, Waldenberger, M, Eriksson, J G, Esko, T, Franke, L, Gieger, C, Relton, C, Davey Smith, G

Publikováno v: Molecular Psychiatry, 22(12), 1680-1690. Nature Publishing Group
Karlsson Linnér, R, Marioni, R E, Rietveld, C A, Simpkin, A J, Davies, N M, Watanabe, K, Armstrong, N J, Auro, K, Baumbach, C, Bonder, M J, Buchwald, J, Fiorito, G, Ismail, K, Iurato, S, Joensuu, A, Karell, P, Kasela, S, Lahti, J, McRae, A F, Mandaviya, P R, Seppälä, I, Wang, Y, Baglietto, L, Binder, E B, Harris, S E, Hodge, A M, Horvath, S, Hurme, M, Johannesson, M, Latvala, A, Mather, K A, Medland, S E, Metspalu, A, Milani, L, Milne, R L, Pattie, A, Pedersen, N L, Peters, A, Polidoro, S, Räikkönen, K, Severi, G, Starr, J M, Stolk, L, Waldenberger, M, Eriksson, J G, Esko, T, Franke, L, Gieger, C, Relton, C, Davey Smith, G & BIOS Consortium 2017, ' An epigenome-wide association study meta-analysis of educational attainment ', Molecular Psychiatry, vol. 22, pp. 1680-1690 . https://doi.org/10.1038/mp.2017.210

The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that environmental influences on the epigenome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9547f1e8dfd23a77509e010c6551ee76
https://research.rug.nl/en/publications/2e4d9bcc-a7a4-4aec-9352-6d5391427cd8

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Issues in the reporting and conduct of instrumental variable studies: a systematic review

Autor: Davies, N. M, Davey Smith, G, Windmeijer, F. & Martin, R. M.

Publikováno v: Epidemiology 24, 363–369 (2013)..

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::d4e2194d3ccbce7ba40364b7d381b6cd