Zobrazeno 1 - 10
of 292
pro vyhledávání: '"DAVID R. SIBLEY"'
Autor:
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1552 (2023)
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition. β-arrestins are believed to interact with G protein-coupled re
Externí odkaz:
https://doaj.org/article/a4efa938f10740ff9782ac55fdd0a957
Autor:
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104771- (2022)
Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets
Externí odkaz:
https://doaj.org/article/073b353a30d149d4b39ba15b63d8a932
Autor:
Despoina Aslanoglou, Suzanne Bertera, Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators of metabolism. Pancreatic catecholamine signaling has also been increasingly impl
Externí odkaz:
https://doaj.org/article/b9206d5d35df46e48ee2e0a5e574828b
Autor:
Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREAD
Externí odkaz:
https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/23d6785a2031469ca8b8f5e613e3237a
Autor:
Miriam E. Bocarsly, Daniel da Silva e Silva, Vanessa Kolb, Kathryn D. Luderman, Sannidhi Shashikiran, Marcelo Rubinstein, David R. Sibley, Lauren K. Dobbs, Veronica A. Alvarez
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1147-1163.e5 (2019)
Summary: Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in
Externí odkaz:
https://doaj.org/article/08124cb0959e470f8713b47acbac6332
Autor:
Lani S. Chun, Rakesh H. Vekariya, R. Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A. Laporte, Amy E. Moritz, Jeffrey Aubé, Kevin J. Frankowski, David R. Sibley
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is n
Externí odkaz:
https://doaj.org/article/7cb63969a0f5446681fd8a8f2474c51c
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Pharmacological studies indicate that dopamine D1-like receptors (D1 and D5) are critically involved in cognitive function. However, the lack of pharmacological ligands selective for either the D1 or D5 receptors has made it difficult to determine th
Externí odkaz:
https://doaj.org/article/b465d6eb2f7b463aab046742367717e3
Autor:
R. Benjamin Free, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W. Bertz, Jinbin Xu, Herman D. Lim, Andrés E. Dulcey, Robert H. Mach, James H. Woods, J Robert Lane, Lei Shi, Juan J. Marugan, William C. Wetsel, David R. Sibley
Publikováno v:
ACS Pharmacology & Translational Science. 6:151-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a97836fc59cbf3baf728f6990d1723
https://doi.org/10.1021/acsptsci.2c00202
https://doi.org/10.1021/acsptsci.2c00202
Autor:
Carl T. Ash, Emily E. Anderson, Amy E. Moritz, Patricia K. Dranchak, R. Benjamin Free, James Inglese, Joseph P. Steiner, David R. Sibley, Emmanuel O. Akano
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb37ed1ab826bfdde0bd8a296dff047
https://doi.org/10.1124/jpet.122.178340
https://doi.org/10.1124/jpet.122.178340