Výsledky vyhledávání - "DAVID J. HOLBROOK"

Reduction of tetrachloro(dl-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) toxicity by the administration of diethyldithiocarbamate (DDTC), S-2(3-aminopropylamino)ethylphosphorothioic acid (WR-2721), or sodium selenite in the Fischer 344 rat*1, *2

Autor: Patrick F. Carfagna, Stephen G. Chaney, J. J. Chang, David J. Holbrook

Publikováno v: Fundamental and Applied Toxicology. 14:706-719

Diethyldithiocarbamate (DDTC), S-2(3-aminopropylamino)ethylphosphorothioic acid (WR-2721), and sodium selentite have all been shown to effectively reduce cisplatin toxicity. As a result, we have investigated the efficacy of these compounds to reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59a360f1a85843cb132a61d2da5ce6d
https://doi.org/10.1016/0272-0590(90)90296-v

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HPLC and 31P NMR characterization of the reaction between antitumor platinum agents and the phosphorothioate chemoprotective agent S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721)

Autor: David J. Holbrook, Steven D. Wyrick, Stephen G. Chaney, D. Charles Thompson

Publikováno v: Biochemical pharmacology. 50(9)

In prior studies, we examined the effects of the radioprotective and chemoprotective agent WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] on the in vivo biotransformation of the cisplatin [cis-diamminedichloroplatinum(II)] analog ormapla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0770124668fc0dd692f9b7cb5c5e08
https://pubmed.ncbi.nlm.nih.gov/7503792

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Organ-specific biotransformation of ormaplatin in the Fischer 344 rat

Autor: Steven D. Wyriok, David J. Holbrook, Stephen G. Chaney, D. Charles Thompson, Michael K. Sakata, Alexandra Vaisman

Publikováno v: Cancer chemotherapy and pharmacology. 36(5)

We examined the intracellular biotransformation products of ormaplatin [(d,l-trans)1,2-diaminocyclohexanetetrachloroplatinum(IV)] (formerly called tetraplatin) in liver, kidney, spleen, small intestine, and plasma of the adult male Fischer 344 rat. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe5e3e8354c489d2b71dbb3797f9d97
https://pubmed.ncbi.nlm.nih.gov/7634386

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In vivo and in vitro effects of helenalin on mouse hepatic microsomal cytochrome P450

Autor: Iris H. Hall, Stephen G. Chaney, David J. Holbrook, Lee Kuo-Hsiung, Dennis E. Chapman

Publikováno v: Biochemical pharmacology. 41(2)

Helenalin, a natural plant product with significant antitumor activities, decreased male BDF1 mouse hepatic microsomal cytochrome P450 contents in vivo and in vitro. A single i.p. dose of 25 mg helenalin/kg body weight significantly (P less than 0.05

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f7bd7f53d76d035a4b14daf51f14c5
https://pubmed.ncbi.nlm.nih.gov/1989634

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Effects of diethyldithiocarbamate (DDTC) on the plasma biotransformations of tetrachloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) in Fischer 344 rats

Autor: Steven D. Wyrick, Stephen G. Chaney, David J. Holbrook, Patrick F. Carfagna

Publikováno v: Journal of biochemical toxicology. 6(1)

We have studied the effects of diethyldithiocarbamate (DDTC) on the biotransformations of toxic doses of tetrachloro (d,l-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) in Fischer 344 rats. In animals not treated with DDTC, tetraplatin was ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3727458961c02c340bd97ef1c459128
https://pubmed.ncbi.nlm.nih.gov/1652641

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Comparisons of tetrachloro(d,l-trans)1,2-diaminocyclohexane-platinum(IV) biotransformations in the plasma of Fischer 344 rats at therapeutic and toxic doses

Autor: Allen Poma, Patrick F. Carfagna, David J. Holbrook, Steven D. Wyrick, Stephen G. Chaney

Publikováno v: Cancer chemotherapy and pharmacology. 27(5)

Plasma biotransformations of tetrachloro(d,l-trans) 1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) were determined in vivo at both therapeutic (3 mg/kg) and toxic (12 mg/kg) doses in Fischer 344 rats. Tetraplatin was rapidly converted to dichloro(d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b775320baeafce826755b00f178e3b
https://pubmed.ncbi.nlm.nih.gov/1998992

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Renal, hepatic, cardiac and thymic acute toxicity afforded by bis(helenalinyl)malonate in BDF1 mice

Autor: David J. Holbrook, Li Ming Yang, Kuo Hsiung Lee, Stephen G. Chaney, Iris H. Hall, Jer Jang Chang, A. A. Grippo

Publikováno v: Toxicology. 64(2)

Bis(helenalinyl)malonate [BHM], a pharmacologically active sesquiterpene lactone potentially useful as an antineoplastic agent, proved to be less toxic than its parent compound, helenalin. Its LD50 in BDF1 mice, i.p. was more than twice that of helen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066c05bfddbbcf3eda0cd3b5c759803f
https://pubmed.ncbi.nlm.nih.gov/2219141

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